In one of Balddumborat's Q&A videos as Derpy Hooves/Ditzy Doo, she is asked whether pegasus ponies wake up with "morning wing" (a reference to the "Wingboner" meme). The response: "Oh, gosh, yeah, we do sometimes. I mean, try sleeping on your back or side with a pair of wings. They really cramp up in the morning and feel horribly stiff. It takes a while to shake them out. But at least we don't have magic messes in the morning like unicorns!"
Snake's description on how he wants his weenie roasted in 'The Camping Webisode' of DSBT InsaniT, which is why Martha lets Andy get away with his perverted "Oh my!" without slapping him.
Snake: Make my weenie warm on the inside, but still cold and slick on the outside. It'll slide down my throat easier that way.
At some point, Gaea, female and very greedy, is alone with an older, male player whose dialogue suggests he's about to ask her for money. Her reaction to this? Looking very worried and bluritng out the following line : "Don't come any closer, especially if you want what I think you want!".
There's also a plotline involoving a top player who turned up to be getting his avatar illlegally enhanced beyond what game mechanics allow. Now, what would be the equivalent of that if the webseries was a sports story rather than about MMORPG players?
In Jake And Amir, the two title characters' bizarre friendship is often portrayed as a gay relationship. Amir constantly wants to spend time with Jake, becomes jealous when Jake spends time with other people, and, on one occasion, received a marriage certificate (from a drag queen) stating that the two were officially wed. Jake is more aware of the connotations and tries to avoid them, but a few episodes depict him as equally jealous when Amir has a girlfriend; in another arc, he gets temporarily transferred to California, and meets a sexy coworker, only to drive her off by thinking and talking about Amir nonstop. The whole situation is lampshaded in an episode featuring Pat and Sarah: Sarah points out that, to the casual observer, the two seem to be a married gay couple. Of course, this being College Humor, the episode has Jake and Amir by the elevators, fighting in a way that's deliberately designed to look like gay sex.