Voice Actors: David-Myles Brown (Australia), Samuel Vincent (US)The main protagonist and his alter-ego, the titular superheroine. Guy was weirded out by his new identity for about two minutes before deciding that the superpowers and she-matic super gadgets were well worth the price of wearing a girly costume. Being the one with the super strength, s/he naturally does all the heavy lifting, but also has to work personal appearances into his/her schedule, as SheZow is a very public figure in Megadale.
Voice Actor: Diana KaarinaGuy's twin sister, president of the official SheZow fanclub, and the superheroine's self-proclaimed number 1 fan. Unlike Guy, Kelly jumped at the chance to actually become her idol and would have if not for his interference. She takes it in stride, though, and becomes SheZow's backup with her in-depth knowledge of everything she-lated: powers, gadgets, and enemies alike. As the more serious-minded of the siblings, Kelly constantly has to remind Guy that he has she-sponsibilities as a superhero. Heroine. Whatever.
Voice Actor: Matt HillGuy's best friend and the only one who has figured out his she-cret identity (OW! Okay, okay, we'll stop now.) so far. Maz very quickly latches onto the idea of being SheZow's sidekick and shows up in a different costumed persona every episode. Few of them are ever very good in a fight but then again, Maz never really has to be rescued either. He can take care of himself. Maybe.
Voice Actor: Jacquie BrennanThe snide, smartmouth supercomputer that inhabits the She-lair and consistently monitors Megadale for threats. Initially she doesn't think much of Guy.
Voice Actor: Dan HamillGuy and Kelly's father, a beat cop who takes his job very seriously and dislikes SheZow's interference because it creates an impression that the police can't do their job. Because of this, he would love to bring her in for some offense or other and ends up rooting for the villain on occasion.
Voice Actor: Elizabeth NabbenGuy and Kelly's mother, a poet and artist. Unlike Boxter, she is a huge fan of SheZow.
ColdfingerThe former president of the official SheZow fanclub and former self-proclaimed number one fan until something terrible happened. Now he has taken over the Megadale Ice Company where he lives with his mother, who doesn't seem too bothered by the fact that her son is an ice-wielding supervillain.
Voice Actor: Jacquie BrennanA former superheroine who would often team up with the previous SheZow to fight crime, but eventually drifted apart after SheZow became famous and she faded into obscurity. Even after years of therapy, Tara still nurses a grudge against her without realizing that Agnes is dead.
MegamonkeyAn evil, super-intelligent monkey from the future that has time-traveled to the present to eliminate SheZow because, in his timeline, she has trapped him in a jar. To help him accomplish this goal, he forms the Society of Incredibly Callous Kriminals (SICK), of which he is the only regular member.
MocktopusA combination shark and octopus that constantly repeats everything people say in a high pitched, whiny (dare we say, mocking?) tone. He may look harmless and never give SheZow much trouble, but he's still a gigantic monster with an array of sharp teeth and tentacles. That's gotta count for something.
Voice Actors: David-Myles Brown (Australia), Samuel Vincent (US)An evil clone of Guy that was created when one of his fingernails fell into a vat of toxic waste. He exists only to cause chaos and ruin SheZow's reputation, having a very similar appearance and many of the same powers and gadgets. Unlike Guy, SheZap has the ability to jump through shadows.
GrillaA version of Coldfinger from DudePow's alternate universe whose theme is the opposite of Coldfinger's, preferring fire powers and red-hot chili peppers to his ice and technological gadgets.
Agnes MonroeThe previous SheZow, as well as the former owner of the Hamdons' current house. Guy and Kelly's deceased great aunt.
Voice Actor: Cecelia RamsdaleA female version of Guy from an alternate universe who transforms into the superhero DudePow, who is very much like SheZow, down to the superpowers, gadgets, secret lair, and rapid fire "He" puns. He even has a female alternate universe version of Maz for a sidekick. Initially, DudePow and SheZow do not get along and squabble over turf, but eventually they decide to put aside their differences and work together.