- Bizarro Film: Contains Surreal Horror mixed with Deranged Animation.
- He Really Can Act: Chris Kattan, who convincingly does a Brendan Fraser impression — and is convincing as a jelly-limbed corpse, too.
- Humor Dissonance: Stu's Monkeybone cartoon is in-universe praised as a stroke of comedic genius that is sure to become a merchandising giant, but to most viewers it just comes across as like a really low-effort Gross-Out Show and the shtick of the Monkeybone character himself appears to be that he constantly displays annoyingly hyperactive and sleazy behavior and engages in not particularly funny impersonations.
- Nightmare Fuel: The cat girl implications of eating the mouse guy.
- The coma realm in general.
- The Nightmare sequence where Stu ends up in one of his paintings that involves a surgeon trying to cut into Stu, who is a carrot in this scene.
- A lot of the inhabitants of Down Town. They really are the monsters of nightmares.
- The scenes where Stu is forced to take the body of a dead corpse might be disturbing to some viewers.
- Oneirix, In-Universe, IS, IN FACT, literal nightmare fuel. Monkeybone and Hypnos' plan is to use it to cause nightmares at a mass scale thanks to the Monkeybone dolls.
- They Wasted a Perfectly Good Plot: Imagine if Cool World had better visuals, but made even less sense.
- Visual Effects of Awesome: The stop motion is easily the best thing about the movie.
- What Do You Mean, It Wasn't Made on Drugs?: Stu nearly dies, leaving his body open to use to another soul — a chance pounced upon by his eponymous creation (which, in his head, is the embodiment of his libido). While Monkeybone wreaks surreal havoc in this world, his creator has to barter with Dream and Death in the hereafter.
- WTH, Casting Agency?: Brendan Fraser, a man often cast as action leads, as an awkward, dorky cartoonist. Hard to believe this guy would draw a cartoon like Monkeybone.
YMMV / Monkeybone