- Billing Displacement: Despite Mathew Baynton playing the protagonist and the antagonist of the series, as well as providing the opening narration, he is still billed second, behind Jenna Fischer.
- California Doubling: Used and averted.
- Malta and South Africa double up for New Mexico; Watford and St Albans in Hertfordshire double up for parts of Slough and the Vatican.
- Other Berkshire scenes in Slough and Windsor were filmed on location however, and Malta also appeared as itself in one episode.
- In a subtle example, a TV newscast based in Oklahoma uses the skyline of Columbus, Ohio, as a backdrop.
- The Danza: almost. Pauline Quirke plays Jamie's mother Paula.
- Fake American: Almost all of the characters from the USA are portrayed by British actors, to the point where it is easier to list off actual American actors appearing on the shownote .
- Playing Their Own Twin: Mathew Baynton plays both Jamie and Ariel.
- Working Title: The show was originally known as Apocalypse: Slough, but was changed as it was feared the Americans would not get the joke ("Slough" rhymes with "now", as in Apocalypse Now). It was changed to You, Me and the End of the World before gaining its final title.
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