- Enforced Method Acting: As Duke comes into the shower room and walks by Malcolm, he snaps the towel at Malcolm's head to get him to shut up about the dorm pamphlet life while ranting at Sebastian. Channing Tatum really hit James Snyder in the eye with the towel and James' reaction is real.
- No Stunt Double:
- Old Shame: Amanda Bynes revealed in 2018 that this movie led her to battle of depression because she didn't like how she looked as a boy.
- Romance on the Set: Amanda Bynes stated she had a tiny crush on Channing Tatum during filming.
- Throw It In!: In the double date scene, as Eunice is sitting down, Amanda Bynes ad-libbed the phrase "Lady pterodactyl." In fact, most outbursts were improvised, like Creator/David ross inviting Sebastian to "have a nice apple and sandwich".
- What Could Have Been: The producers initially wanted Jesse Mc Cartney to play Sebastian, because his facial features are similar to that of Amanda Bynes. He was unavailable, so they cast James Kirk instead.
Trivia / She's the Man