The manga tells the adventure of a boy named Jou as he goes on a Pokémon adventure with his Totodile. It follows the game's plot—beginning with Jou getting his starter from Professor Elm and ending with him battling Red on Mt. Silver.
Jou's Big Adventure was only released in Japan and Thailand.
This manga provides examples of:
- Adaptation Name Change: "Hibiki" becomes "Jou".
- Cute Little Fangs: Jou has fangs to go with his Hot-Blooded nature.
- Named by the Adaptation: The unnamed rival from the games is "Tsubaki".
- Real Men Wear Pink: Tsubaki's starter and only known Pokémon is his Chikorita, an effeminate looking grass type. It later involves into an even more girly looking Meganium.
- The Rival: Tsubaki is this to Jou.
- Shonen Hair: Jou has a huge, angular cowlick poking out of his hat.