- Right in the first episode, the sausage scene. The mundane act of trying to stop food from falling on the floor, played out like an episode of Dragon Ball Z.
- One. Two. Three. Safe.
- Yuuko and Mio's hallway chase scene in second episode.Mio: I! Can't! Let! That! Happen! My life... IS ON FIRE!
- Yuuko and Mio arguing so hard in Episode 14 that it turns back into friendship. Doubles as a heartwarming moment.
- The Go-soccer match in Episode 19. Full stop.
- The entire battle with the Principal and the Deer, ending with the principal SUPLEXING THE DEER.
- Mio one-hit KO-ing everyone (including a policeman and Sasahara's goat) over her drawings, as seen in Episode 16.
- Mio vs the Airship crew in Episode 21.
- Yuuko and Mio's chase scene in Episode 25.
- Manga chapter 143: Mio's sister Yoshino meets Mai. Troll-on-Troll Combat ensues! It's a draw.
- Manga chapter 171: Yuuko resists one of the Professor's temper tantrums. How? By throwing an even bigger tantrum, then proceeding to distract the Professor with something nonsensical.
- Manga chapter 178: Nano shows off some unexpected functions.
- The hard climb the anime has had over 8 years (Bandai shutting down without having a chance to physically release it, then Funimation initially releasing it sub-only after its rescue) to finally getting an English dub (something fans almost thought impossible due to its frequent wordplay) is nothing short of amazing.
Awesome / Nichijou