Banned Episode: Due to matters of the Action League Now! short "Caged Thunder", The episode ("I Just Don't Get It") was banned from airing on Nickelodeon in North America after the 9/11 attack.
Channel Hop: In the Netherlands, the show was syndicated for the dubbed version, and was moved to Nicktoons for the subbed version.
Cross-Dressing Voices: The main kids in The Offbeats segments were voiced by young children, most notably Mischa Barton as Betty-Anne Bongo. The later episodes had several of the kids' voices sounding a bit lower, including the females (who were voiced by girls). The only adult voice actors were series creator Mo Willems, who voiced September the dog and Grubby Groo, and Kevin Seal (better known as the voices of Sheep and General Specific) providing Tommy's yelling voice. Not to mention that Henry and June were done by kids, along with Loopy and Larry.
Noah Segan, who did Henry, was also in the 1995 season finale of Married... with Children as a kid blackmailing Kelly into going with him to his elementary school prom, and made occasional appearances on early 1990s episodes of Saturday Night Live as a recurring extra in sketches that called for actual children to appear and not 20 to 30-something-year-old cast members who can pass as children (albeit overgrown ones).
June's voice actress (Julia McIlvaine) was on Cartoon Network's Mad voicing various characters.
Keep Circulating the Tapes: This show never got any VHS or DVD releases, and doesn't look like it ever will for the time being. The only way you can see the show is through YouTube (provided it hasn't been removed for copyright reasons) and on the website nickreboot.com (though you have to sign up in order to see it), which airs a lot of old-school Nickelodeon shows.
Production Posse: Rick Gomez plays Sniz, and also was in another show from the creators, The Adventures of Pete & Pete, as bully "Endless" Mike Helstrom. However, Will McRobb and Chris Viscardi (the creators) didn't know that he was going to be on the show (all the shorts had their own casting), and Gomez didn't know that McRobb and Viscardi were working on the show.
Talking To Herself: Dawn and June are both voiced by Julia McIlvaine, if Wikipedia is to be believed.
What Could Have Been: The show was originally going to take place in a live action comic book, with the shorts being Henry and June, Action League Now!, and some old Nicktoons shorts.
Sniz and Fondue's pilot, "Psyched for Snuppa", was one of the two contenders for the fourth Nicktoon in 1992. The show it lost to? Rocko's Modern Life (all things considered, it's not that bad, but still, it would have been nice for Sniz and Fondue to have their own show).
There was going to be a spinoff show called "The Henry and June Show" and focused on Henry and June and premiered in 1999. It had only two segments: the first segment, "A Show of Their Own", featured Henry and June with a studio audience and musical guests. The next segment was "Be True to Your School", where Henry and June attend school, and try their best to tackle hard subjects like "How to Look Your Best". It was never again shown after it premiered. One must wonder what happened to have Nickelodeon cancel it after two segments, and where the clips are now.
When a fan asked Mark Marek (creator of Henry and June) about The Henry and June Show, Marek responded, "The Henry and June show only [aired] once as you noted. Not planning to release the pilot any time soon. Believe me, you don't want to see it. It's rough."
Prometheus and Bob was going to be given a Live-Action adaptation for a feature film. However due to a lack of interest, the idea was ultimately given to The Off-Beats.