Brian gets in one of his own in a later episode after unknowingly sleeping with Quagmire's father. (who had undergone a sex-change operation)
Brian: Hey! Quagmire: WHAT? Brian: I fucked your dad.
The trope would apply to most of the swears in Family Guy since, despite this being an adult show, harsher swear words (like "shit" and "fuck") are still fairly rare, so when they do swear it tends to stand out a lot.
Brian: Peter, I don't wanna say "I told you so", but....YEEAH! IN YOUR FUCKING FACE FUCKWAD!!
Each entry in the Star Wars parody trilogy contains one precision F-Strike.
Lisa Simpson swears by far the least number of times of any Simpsons character. She only does so once: in "The Night of The Dolphin", where she is bit by a dolphin, causing her to yell, "Son of a bitch!"
Kent Brockman: Folks are finally accepting their feelings and really communicating with no holding back. And this reporter thinks it's about fucking time.
From, "Homer The Whopper". Not much of a swear, but it was still bleeped.
Lyle McCarthy: Something bad happens and you cope by cramming a donut in your mouth. Homer: Well you don't always have time to masturbate.
In, "Girls Just Want to Have Sums", Lisa must dress like a boy (and is now addressed as 'Toilet') in order to attend the male side of Springfield Elementary (Long story). The conversation she has with an unknowing Milhouse shocks her:
Lisa/Toilet (raspy voice): Did you know Lisa Simpson? I heard she was pretty cool. Milhouse: Lisa? Oh yeah, we totally had a thing, but I had to break it off. Lisa/Toilet (normal voice): WHAT THE HELL ARE YOU TALKING ABOUT?!
How shocking was Homer's explosive swear in "Who Shot Mr. Burns? Part 1"? His own children somehow knew what word he was about to use, and they looked scared when he quietly told them, "Kids, would you step outside for a second?"
Butters doesn't swear often, and thus it has a far greater effect when he does. The rest of the characters swear like crazy doesn't really matter: it's very much to do with the individual.
Comedy Central seems to agree that this is effective, as he was allowed to say "Ah, shit." at the end of "Imaginationland". As we all know from the episode "It Hits The Fan", the network has a history of only allowing them to use that word when the situation calls for it.
Another classic was his cheering "Fuck him up, Wendy!" when Wendy fights Cartman in Breast Cancer Show Ever.
A particularly brilliant one comes at the end of "Christian Rock Hard", when, after being screwed over by Cartman, Butters calmly walks over to him, farts in his face, gives him the finger and says "Fuck you, Eric." He then calmly walks away.
"It Hits The Fan" also spoofed this trope when the use of a single swear word was hyped on a TV show was hyped in the media. The actual sentence came at the end of the fake episode, "Oh, by the way, you got some shit on your face there."
In the episode "All About Mormons" Gary, the son of the Mormon family that moved into down, gives a somewhat powerful, thought provoking speech at the end of the episode, ending it with "suck my balls." This is pretty tame for South Park, but given that Gary was Mormon and the entire family used clean, frequently cutesy language throughout the episode it was a Precision F Strike for the character in question.
And there was also that time Kenny was eaten by a giant bird that busted through the ceiling after the plot of the episode was already resolved.
Similar to the South Park example, most of the cast of Drawn Together swear like sailors. Princess Clara, on the other hand, uses profanity very sparingly, so when she drops an F-bomb, you notice it.
In Dexter's Laboratory, the gym teacher says the exact same thing in reaction to Dexter's excuse note.
In Superman/Batman: Public Enemies, after being betrayed by Amanda Waller, Lex Luthor simply turns to face her and says "Bitch." It is rated PG-13, but the fact that the line is spoken by Clancy Brown after years of him playing Mr. Krabs on Spongebob makes it more surprising, awesome and funny.
Batman: You think you know everything about me, don't you? Alfred: I diapered your bottom. I bloody well ought to... sir.
There's a classic "blooper" clip of Porky Pig (presumably a studio gag reel or something like that) smacking his thumb with a hammer while pounding a nail, and muttering, "Son of bi-bi-bi, son of a bi-bi-bi, son of a bi-bi-bi-Gun!" He then turns to the camera and adds, "Ha-ha-ha, you thought I was gonna say s-son of a Bitch, didn't you?"
Every time that Total Drama Island unleashes something bleeped in-show, it's always either really awesome or really hilarious.
DJ and his "Oh, shit" when facing the first challenge.
Lindsay insulting Heather with a really long list of (bleeped) insults (complete with middle finger) after finding out how much she's used her the entire season.
Izzy and her Shout-Out to Christian Bale in the Celebrity Manhunt special while on a movie set.
Alejandro in the first episode of World Tour, when he finds out how useless his team is. Bonus points for putting on a good face until he gets to the confessional, as well as for the Gratuitous Spanish.
Narrator: On and on they trod though the white sands in the noonday sun and the merciless hell of a waterless desert. DM: You know, Penfold....after trodding on and on through the white sands in the noonday sun and the merciless hell of a waterless desert, I don't quite feel so lucky anymore.
Meatwad: I thought you said television was bad. Frylock: It is. But we f—king need it.
The Venture Bros.: Dean Venture gets one in the last line of the fourth season. "You know what I think? Fuck you!"
King of the Hill manages this without any actual swearing in "Death and Taxes" - Peggy is duped into bringing cocaine to a convict, who will turn her in for that if she refuses to continue supplying him. Hank realizes something's wrong around the halfway point of the episode when she, normally the self-proclaimed smartest woman in the state, forgets to add meat to a dinner dish that is 90% meat and, upon noticing, asks out loud "How could I be so freaking stupid?!".
Another classic Disney example, from Pinocchio: "Ha ha ha! Go on, laugh! Make a jackass out of yourself! I'm through!"
On "Clone High," Mr. Butlertron has a few in Episode 5:
Butlertron: That Scangrade is just such a motherfucking showboat. He's been this way since Amherst.
Butlertron: Before you kill me, I have one request: can you answer a multiple choice question? Scangrade: I'm Scangrade. I grade tests for a living. Ask me your question! Butlertron: Are you a) handsome, b) smart, c) scrap metal, or d) all of the above? Scangrade: That's easy. I'm a) and b), but not c), so I can't be d). You can't fill in two ovals! (explodes) Butlertron: The answer was c). You fuckwad.
Constantine: I know you're the evil genius, but here's what I don't get: if you tell everybody your plan, won't somebody try and stop it? Kamikazi: Exactly. You see, ruining Christmas is merely a ruse to mask my real plan, a plan that will give me the greatest Christmas gift of all time. Constantine:A fur-lined toilet seat? Kamikazi: No, jackass!
Transformers: The Movie has Spike say this when he and Bumblebee fail to stop Unicron with a bomb inside one of Cybertron's moons
It isn't even dented! Oh shit, what are going to do now?!
Gargoyles: In his very first scene, David Xanatos says:
Pay a man enough, and he'll walk barefoot into hell.
While this may have been heard in some of the earlier movies like 101 Dalmatians and Sleeping Beauty, it was unheard of to hear this in a Disney animated series. The first season DVD set even features interviews with fans who recall being amazed when they heard it.
Doug: From the Disney Christmas episode "Doug's Secret Christmas" comes this remark from who better than Doug Funnie. And you won't believe that this was used in context. —> Oh, so, with all that talk about fish and vampires and internal combustion engines, you really wanted to talk to me about sex?