The trope would apply to most of the swears in Family Guy since, despite this being an adult show, harsher swear words (like "shit" and "fuck") are still fairly rare, so when they do swear it tends to stand out a lot.
Brian: Peter, I don't wanna say "I told you so", but....YEEAH! IN YOUR FUCKING FACE FUCKWAD!!
Each entry in the Star Wars parody trilogy contains one Precision F-Strike.
In American Dad!, Steve's friend Snot tends to drop a few f-bombs here and there:
Kent Brockman: Folks are finally accepting their feelings and really communicating with no holding back. And this reporter thinks it's about fucking time.
From, "Homer The Whopper". Not much of a swear, but it was still bleeped.
Lyle McCarthy: Something bad happens and you cope by cramming a donut in your mouth. Homer: Well you don't always have time to masturbate.
Which is particularly odd because Homer used the word in question twice in "The Father, the Son, and the Holy Guest Star" five seasons earlier.
In "Girls Just Want to Have Sums", Lisa must dress like a boy (and is now addressed as 'Toilet') in order to attend the male side of Springfield Elementary (long story). The conversation she has with an unknowing Milhouse shocks her:
Lisa/Toilet (raspy voice): Did you know Lisa Simpson? I heard she was pretty cool. Milhouse: Lisa? Oh yeah, we totally had a thing, but I had to break it off. Lisa/Toilet (normal voice): WHAT THE HELL ARE YOU TALKING ABOUT?!
How shocking was Homer's explosive swear in "Who Shot Mr. Burns? Part 1"? His own children somehow knew what word he was about to use, and they looked scared when he quietly told them, "Kids, would you step outside for a second?"
The most precise of all Precision F-Strikes in The Simpsons comes from the episode "Hurricane Neddy", delivered by Ned Flanders of all people.
Ned: Aw, hell, diddly-ding-dong- crap! CAN'T YOU MORONS DO ANYTHING RIGHT?!
In the "Treehouse of Horror IV" segment "The Devil and Homer Simpson", Homer searches his emergency donut stash, only to find it empty with a note reading "Dear Homer, I.O.U. one emergency donut. Signed, Homer". Upon discovering this, he exclaims "Bastard! He's always one step ahead!" The first word is often left out of TV broadcasts.
In The Simpsons Movie, Marge gets one with "Someone throw the goddamn bomb!" The tv version is just "the damn bomb"
In "The Joy of Sect", both Lisa and Marge angrily yell 'damn'!
Butters doesn't swear often, and thus it has a far greater effect when he does. The rest of the characters swear like crazy doesn't really matter: it's very much to do with the individual.
Comedy Central seems to agree that this is effective, as he was allowed to say "Ah, shit." at the end of "Imaginationland". As we all know from the episode "It Hits The Fan", the network has a history of only allowing them to use that word when the situation calls for it.
Another classic was his cheering "Fuck him up, Wendy!" when Wendy fights Cartman in Breast Cancer Show Ever.
A particularly brilliant one comes at the end of "Christian Rock Hard", when, after being screwed over by Cartman, Butters calmly walks over to him, farts in his face, gives him the finger and says "Fuck you, Eric." He then calmly walks away.
"It Hits The Fan" also spoofed this trope when the use of a single swear word was hyped on a TV show was hyped in the media. The actual sentence came at the end of the fake episode, "Oh, by the way, you got some shit on your face there."
In the episode "All About Mormons" Gary, the son of the Mormon family that moved into down, gives a somewhat powerful, thought provoking speech at the end of the episode, ending it with "suck my balls." This is pretty tame for South Park, but given that Gary was Mormon and the entire family used clean, frequently cutesy language throughout the episode it was a Precision F-Strike for the character in question.
And there was also that time Kenny was eaten by a giant bird that busted through the ceiling after the plot of the episode was already resolved.
Similar to the South Park example, most of the cast of Drawn Together swear like sailors. Princess Clara, on the other hand, uses profanity very sparingly, so when she drops an F-bomb, you notice it.
In Dexter's Laboratory, the gym teacher says "what is this crap?" in reaction to Dexter's excuse note.
At the end of "Rude Removal", Dexter goes "Oh, shit." after his mom said she's going to clean his & Dee-Dee's mouths with soap.
In Samurai Jack, a robot mutters "God dammit" when explaining how powerful the Mondo-Bot is.
Looney Tunes: There's a classic "blooper" clip of Porky Pig (presumably a studio gag reel or something like that) smacking his thumb with a hammer while pounding a nail, and muttering, "Son of bi-bi-bi, son of a bi-bi-bi, son of a bi-bi-bi-Gun!" He then turns to the camera and adds, "Ha-ha-ha, you thought I was gonna say s-son of a Bitch, didn't you?"
Every time that Total Drama Island unleashes something bleeped in-show, it's always either really awesome or really hilarious.
DJ and his "Oh, shit" when facing the first challenge.
Lindsay insulting Heather with a really long list of (bleeped) insults (complete with middle finger) after finding out how much she's used her the entire season.
Izzy and her Shout-Out to Christian Bale in the Celebrity Manhunt special while on a movie set.
Alejandro in the first episode of World Tour, when he finds out how useless his team is. Bonus points for putting on a good face until he gets to the confessional, as well as for the Gratuitous Spanish.
Narrator: On and on they trod though the white sands in the noonday sun and the merciless hell of a waterless desert. DM: You know, Penfold....after trodding on and on through the white sands in the noonday sun and the merciless hell of a waterless desert, I don't quite feel so lucky anymore.
Meatwad: I thought you said television was bad. Frylock: It is. But we f—king need it.
The Venture Bros.: Dean Venture gets one in the last line of the fourth season. "You know what I think? Fuck you!"
King of the Hill manages this without any actual swearing in "Death and Taxes" - Peggy is duped into bringing cocaine to a convict, who will turn her in for that if she refuses to continue supplying him. Hank realizes something's wrong around the halfway point of the episode when she, normally the self-proclaimed smartest woman in the state, forgets to add meat to a dinner dish that is 90% meat and, upon noticing, asks out loud "How could I be so freaking stupid?!".
From the Futurama episode "The Silence of the Clamps", we have this gem aimed towards Robot Mafia goon Clamps:
On Clone High, Mr. Butlertron has a few in Episode 5:
Butlertron: That Scangrade is just such a motherfucking showboat. He's been this way since Amherst.
Butlertron: Before you kill me, I have one request: can you answer a multiple choice question? Scangrade: I'm Scangrade. I grade tests for a living. Ask me your question! Butlertron: Are you a) handsome, b) smart, c) scrap metal, or d) all of the above? Scangrade: That's easy. I'm a) and b), but not c), so I can't be d). You can't fill in two ovals! (explodes) Butlertron: The answer was c). You fuckwad.
Constantine: I know you're the evil genius, but here's what I don't get: if you tell everybody your plan, won't somebody try and stop it? Kamikazi: Exactly. You see, ruining Christmas is merely a ruse to mask my real plan, a plan that will give me the greatest Christmas gift of all time. Constantine:A fur-lined toilet seat? Kamikazi: No, jackass!
Gargoyles: In his very first scene, David Xanatos says "Pay a man enough, and he'll walk barefoot into hell." While this may have been heard in some of the earlier movies like 101 Dalmatians and Sleeping Beauty, it was unheard of to hear this in a Disney animated series. The first season DVD set even features interviews with fans who recall being amazed when they heard it.
In another early episode, Elisa actually says "Damn!" in frustration. The line was said quietly enough a kid might miss it, but it's still amazing Disney allowed an actual swear.
Mr Herriman:' Good heavens! What's happening?! Bloo: You PISSED HIM OFF, that's what happening!!!
Fluttershy from My Little Pony: Friendship Is Magic of all ponies has one in "Putting Your Hoof Down", during her increasingly rage-filled tirade against Pinkie Pie and Rarity. While she doesn't use an actual curse word, but an obvious substitution for "fuck," the context in which she says it, and they way she says it provides just as much impact as if it had been an actual F-bomb. It also stands out as an example of O.O.C. Is Serious Business, since Fluttershy is normally very quiet and sweet: the last pony anyone would expect to say anything that even resembled a swear.
Rarity: Now, stop right there! Let's not let things descend into petty insults. Fluttershy: Why not? I thought "petty" was what you're all about, Rarity, with your petty concerns about fashion. Pinkie Pie: Hey, leave her alone; fashion is her passion! Fluttershy: Oh, and what are you passionate about? Birthday cake? Party hats? I can't believe that the two most frivolous ponies in Ponyville are trying to tell New Fluttershy how to live her life, when they are throwing their own lives away on pointless pursuits that nopony else gives a flying feather about!
Played with in a later episode, when we discover that the one thing that really makes Fluttershy lose her composure is dealing with her obnoxious brother Zephyr Breeze. She mentions in public that he makes her "peeved," and this word is apparently considered unspeakably profane in the world of the show. Parents cover their children's ears and glare at her in response.
In "Fluttershy Leans In", Rainbow Dash exclaims "Buck yeah!".
Being a Canadian production, a feature film and having the rating of PG Pirates Passage features words and phrases such as "Bastards", "Son of a bitch" and "Jesus Murphy."
BoJack Horseman makes brilliant use of this trope. Despite being a Netflix show that can use the word as often as they like, it's deliberately used exactly once per-season for scenes in which the title character's self-destrictive lifestyle had done irretrievable damage to a relationship. The result is a walloping dramatic effect.
Herb:[not supporting/contacting him for 20 years] ...And you abandoned me. And I will never forgive you for that. Now get the FUCK out of my house! Charlotte:[being almost under-dressed in the same room with her daughter just minutes after she turn him away] ...And if you ever try to contact me or my family again, I will FUCKING kill you. Todd:[having sex with his potential girlfriend and refusing to change] ...FUCK, man. What else is there to say?
This was jokingly put to the test in season 3: "Love And/Or Marriage" ends with Diane being cut off while screaming "MOTHERF-!" upon learning that she's pregnant. The immediate next episode beings with her screaming "-UCKER!!"
Animated PSAs by Street Kids International have the occasional swear, despite being made primarily for kids.
Regular Show has Mordecai saying "You pissed me off." to Rigby.