In The Angry Video Game Nerd's video on Die Hard: The Licensed Game for the NES, the nerd attempts to properly beat the game. The game proves to be so frustrating that everything around him explodes while the Die Hard music plays and he is constantly jumping and rolling away from the blasts, as well as sweating and bleeding. Eventually, sick of the game, he rips the game out of the NES, yells "Yippie-Ki-Yay, motherfucker!!" and throws it behind him and jumps Die Hard style from the massive explosion it causes.
In the middle of The Final Brawl, with epic battle going on around them, the Nerd dramatically bellowing and raising his fist... before placing a Geek Fight card on a table. The Critic responds in kind, and they argue about the power level...
"First: You need to put... your... gloves on. No matter how long it takes, NO MATTER THE DIFFICULTY, you must GET IT ON!"
Lampshaded on The Spoony Experiment during his Phantasmagoria review. During one scene when ominous music is playing, he sings (with the music) "Cubicle isn't scary!" Also during very boring scenes the Spoony One will shout "PHANTASMAGORIA! PUZZLE OF THE FLESH!"
Goku: "Gohan, follow Krillin. Get home to your mother."
Gohan: "Right, daddy. Is there anything you want me to tell her?"
Goku: "Yes, Gohan. Tell her..."
* Zoom in to Goku. Hardcore rock guitar.*
Goku: "...to put dinner on!"
* More zoom. Guitar continues.*
Goku: "..because I'm hungry!"
* Extreme close-up. Guitar continues and then dies out.*
Rhett & Link love this trope. Their songs include "Phatdippin'," "Epic Rap Battle," "In The '80s," and "The Shamwow Song," and a short video series called The Surrogate Sharers, in which they present embarrassing confessions on behalf of others.
Retro Game Master, a translation of a Japanese TV show, can get into this pretty often. It's about a guy trying to complete classic NES-era games in single playthroughs. The commentary translation sounds very literal, which in English tends to result in some... interesting emphasis. MIGHTY BOMB JACK, anyone?
In Plague And Treachery On The Oregon Trail, when the decision came over what to do once they reached Snake River, Chewbot said he'd count anyone who posted their vote in the form of a haiku as two votes.
Think about it. What's more ridiculous than dozens of internet strangers voting on the river-crossing status of a fictional family based on an educational game that was created 30 years ago? Haiku about it.
Barats and Bereta are quite fond of this trope and have turned ordinary things like children's games, the Neighborhood Watch Committee, April Fools' Day, and taking shots into unbelievably awesome things using dramatic music, dramatic lighting, and Narm.
"Shrimp on a Treadmill" is interesting enough as a study of how diseases and pollution affect the endurance of ocean creatures. Then YouTube got hold of it and started making music videos...
ThisLiveJournal comment: "DO YOU ALL HEAR ME?! THE HOUR OF JUSTICE IS COMING FOR ALL BITCHES, THE HOUR OF TRUTH!!!" in response to someone's fanfic getting a negative review.
Celebrity gossip blog Just Jared writes breathless, awestruck stories about celebrities doing mundane things. Activities such as grocery shopping, taking their kids to school, doctor's visits and going to Subway for lunch are presented as being so much more amazing than normal because reality show contestants and bottom tier celebrities are doing them.
ThisYouTube video has a political commentator going to a protest gathering outside a town hall and he tried to play up the (mostly harmless) people there as a dangerous angry mob.
Desert Strike: Return to the Gulf - Epic Version. The Very True, Incredibly Epic and Completely Heroic story of how Lieutenant G.W. Bush won the first gulf war. "Take That, Iraqistan!". Megadrive game updated with a Big Damn Score by some of Hollywood's finest.
Vegan Black Metal Chef combines metal music, studded leather, face makeup, Satanic imagery, and intricate sacrificial knives to make... a vegan cooking show.
Every time Shesh Besh (a.k.a. Backgammon) is played it is precisely this awesome.