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- Angel Beats! an anime set in purgatory, more or less, reveals in episode nine that just moments before Otonashi died he signed a donor card, in the hopes his death wouldn't be in vain. It's shown in episode 13 that indeed, it wasn't in vain as Kanade has his heart.
- In Boku no Hatsukoi wo Kimi ni Sasagu, main character Takuma suffers of a heart disease. Eventually, the condition for Takuma to get better is to get a heart transplant. Kou gets appointed as the donor, but both Takuma and Kou's family reject it.
- Adorea of Franken Fran has this in her backstory: she and her boyfriend had life-threatening illnesses, and they each promised they would give their organs to the other should one of them pass away. The boyfriend died first, so Fran's father donated the organs to Adorea before working his magic on the boyfriend to revive him; the callous boyfriend demanded the organs back, turning Adorea into the...uh..."person" that she is now.
- One of the murderers in The Kindaichi Case Files has trying to find a matching kidney for his sick daughter in his backstory—he got involved in the Organ Legging business, and the man he murdered found out and was blackmailing him over this.
- In Pet Shop of Horrors, the dictator of a country is hiding out in America and is in need of an organ transplant. The doctors decide to use the heart of a baboon to do the job, only for said baboon to be kidnapped. Cue a mad rush to find the thing, for fear of sparking a messy political situation. And then it turns out that the kidnapper is a man whose daughter also needs a heart transplant. The dictator winds up being sniped by someone from his country and they end up giving the baboon's heart to the girl after all. Oh, and there's a subplot where D is apparently suffering from some disease and his "sister" is sent by their father to give her dear brother any of her organs or body parts to cure him. She herself is actually a baboon, and is killed by the shop's pets when D refuses to accept her offer and she attacks him. Needless to say, it was a creepy story.
- A running theme in Ray and the animated series based on it. Ray herself was raised on a farm designed to provide black market organs, this was how she lost her eyes, only to have them replaced by X-Ray eyes.
- Purely hypothetical in Strawberry Marshmallow: Miu is claiming that her friendship with Chika is closer than that of Ana and Matsuri. One test is what one friend would do if the other needed the first's organs. Matsuri and Ana would definitely do so, even though Matsuri asks what would happen to her if she were the donor (Matsuri seems to forget for a moment that it is hypothetical and starts crying); Chika is more ambivalent, but comes to the conclusion that she "probably" would, provided that she herself would live. Miu claims "there's no way I'm giving you any of my organs, though."
- In Tokyo Babylon, an Ill Boy named Yuya had an unidentified kidney disorder, which had already killed his twin older sister Maya. Even though his condition kept worsening to the point of emergency surgery he was still on the waiting list, so Subaru eventually decides to donate his own kidney to Yuya. He arrives just after Yuya's taken to emergency surgery again, and Yuya's unnamed mother flips out and attacks him. Seishiro blocks the knife, and Subaru is too upset to do anything. The plotline is never resolved.
- My Little Titan: Part of Rainbow Dash's backstory, shared by her counterpart in The Perfect Match, a fic by the same author. In both stories, when Rainbow Dash was a filly, she came down with a viral disease that attacks and destroys the kidneys, and would have died without a donor kidney. Her life was saved when Fluttershy had herself tested, turned out to be a perfect match, and Stared the doctors and her parents into letting her donate.
- In Airplane!, one of the passengers is being flown to receive a new heart.
- This happens in Awake when Clay's mother kills herself in the hospital waiting room to assure he gets a healthy heart.
- The Clint Eastwood film Blood Work has a detective investigating the murder of the woman whose heart he got.
- The plot of Dumb and Dumber To is jumpstarted by Harry requiring a kidney transplant, and needing to find his long-lost daughter to obtain one. Turns out Harry was faking the whole time, to get back at Lloyd's overlong mental institution prank.
- In The Eye, a woman receives an eye transplant that helps her see into the supernatural.
- Gods, being about pioneer heart transplant, naturally features this.
- John Q. has the title character taking a hospital's emergency room hostage to get his son a heart transplant he can't afford to pay for and his insurance refuses to cover. Further, when there's no suitable donor heart available, he starts planning to kill himself to provide one. He's stopped seconds before he pulls the trigger, when one suddenly becomes available.
- In Return to Me, the female lead's recent heart transplant provides some major plot when she finds out the guy she's dating is the donor's widower.
- Seven Pounds is about The Atoner looking for worthy recipients of his organs before he commits suicide.
- Scifi variant in Star Wars: When R2D2 returns from the attack on the Death Star with some structural damage, C3PO offers to donate any of his circuits or gears that might be needed to repair his companion. Awwww....
- Never Let Me Go starts off as a slightly creepy story about some kids in a boarding school. About a quarter of the way through we find out that the kids are clones being raised to provide organs. By the end we find out that most clones are indoctrinated so much that they keep giving organs until they end up comatose organ mines.
- This turns out to be the basic underlying scheme in Strange Affair by Peter Robinson.
- This trope, plus Walking Transplant, plus Calling The Old Woman Out sparks the plot of My Sister's Keeper by Jodi Picoult. The girl was conceived and born so she would provide organ donations to her ill sister.
- This was the back story in the Michael Connelly novel Blood Work in which an FBI profiler gets the heart from a murder victim. He ends up solving the case. it turns out the serial killer was killing compatible donors for him.
- This is a very common plot Lurlene McDaniel's stories:
- Let Him Live, the heroine befriends and falls in love with a boy who desperately needs a liver transplant. He doesn't make it.
- She Died Too Young has the complication of a heart being available, but two girls need a transplant. The heroine of that particular book gets the heart while the other girl dies.
- Katie O'Roark gets a heart transplant in her debut book. She survives to the end of the One Last Wish series and gets married to her longtime boyfriend.
- The short story "Laura's Heart" has heroine Laura receive the heart of a boy she fell in love with, who was gunned down. He had a feeling his death was imminent, as he'd escaped a gang, and signed the donor forms in advance.
Live Action Television
- In Renegadepress.com's "The Third Wheel", Jack tries to accept that heís not a match for his motherís bone marrow transplant.
- One episode centered around a family with an ill son whose younger sister was conceived for the express purpose of finding a match for a bone marrow transplant.
- There was a black bone/tissue market discovered in one episode. Strange objects were found inside corpses. They were used to replace the harvested organs.
- CSI: NY's episode "Live And Let Die" is this trope, with the variantion that it was the doctor's wife needing the liver. He orchestrates a medical helicopter hijacking and kills several people in the process. Mac is naturally not amused, especially recalling his own pain and loss and talks on the fact that the guy will likely be in prison while his wife dies.
- Grey's Anatomy, many times. The most noteworthy is Denny Dukett, who fell in love with Izzy and was about to get a donor heart when the donor died, meaning that there was only one heart left at that hospital, and it was going to go to another person. Izzy cut his LVAD wire, purposefully worsening his health to bump him up the list. He survived and got the transplant, but died later of a stroke.
- Earth: Final Conflict: Liam Kincaid anonymously donates blood to Ronald Sandoval. Notable because the doctor said it had to be from a first-degree relative (parent or child) to work. Furthermore, Sandoval considers Liam his enemy while Liam's feelings for his human father are a little more complicated.
- Chicago Hope had a few episodes dealing with this.
- A first season episode of has a man whose brother needs a heart transplant, but is far down on the donor list. He finds a gun and then proceeds to take the OR and its staff hostage during an operation to get the heart to go to his brother.
- Another episode dealt with a white racist who needed a heart transplant, but the donor heart that comes available is from a black teenager. The man dies because the nurse assigned to him was Asian, and he threatened to have his friends rape her. She was so afraid of him that she never took blood samples from him, which would have shown he was not a good match for that heart.
- House. Oh so many times.
- There's an episode where a father kills himself to give one of his organs to his son.
- In one episode a patient has to find a kidney on the black market.
- They have a brain-dead donor who'd be perfect for a man with an ailing heart — they just have to figure out what was wrong with her so that the donor board will sign off on it.
- There was the time they had a donated pair of lungs that were going to be implanted but couldn't be because they had some kind of illness, so House was called in to cure them when they were nothing more than a pair of lungs in a box.
- Law & Order:
- "Sonata for Solo Organ" features a millionaire philanthropist who is so desperate to acquire a kidney for his dying daughter (with the added complication that, due to a rare condition, she will reject any organs provided from any donor who is not a specific match to her blood type) that he bribes a doctor to kidnap some guy, steal his kidney then dump him in a park. This episode may have contributed to the persistence of the "kidney theft" urban legend.
- In "Seed," the attorneys are thwarted in their effort to prosecute a fertility doctor who used his own sperm for his IVF patients when their best witnesses refuse to testify. The couple did not want it to become public that they had their second child (via IVF by the doctor) to provide bone marrow for a transplant for their first child, who had leukemia. The marrows did not match, and the first child died.
- "Harvest" had a woman being shot in the head during a robbery and being declared brain-dead. Her grieving husband agreed to donate her organs, only for it to turn out that she wasn't dead yet and the transplant doctor had accelerated the process in order to improve his record.
- There's an episode of Law & Order: Criminal Intent where the villain is giving away his organs to people he feels deserve it, and killing them (in such a way that the organ can be transplanted into someone else) if they stop whatever project or behavior he feels made them deserve it. In the end they get him to confess in exchange for allowing him to continue donating his organs while in prison.
- The M*A*S*H episode "Life Time" deals with a soldier who needs an aorta for his heart, and will either die or wind up paralyzed if not treated within a certain amount of time.
- NYPD Blue: Bobby Simone needed a heart but was far down the list, so they asked all the cops in NYC going out on patrol that day to make sure they sign up for organ donation and stipulate it goes to a cop, Just In Case. The one who ended up dying didn't sign up, and they had to convince his widow to allow them to take his heart. Bobby died anyway.
- One of many Court Cases Of The Week on Picket Fences concerned an elderly man with Alzheimer's, who wanted the legal right to commit suicide under controlled conditions in the hospital so his dying son could receive his heart. A very moving episode, in that the plaintiff was coherent at certain times of day (the "sundowning" phenomenon), and plainly incompetent at others. The son eventually gets the heart of a homeless man who'd frozen to death instead ... only to wind up shooting his dad to spare his dignity after finding him stark naked astride a child's rocking horse. Cue the next Court Case Of The Week.
- In the Scrubs episode "My Lunch", a recurring character commits suicide and three other patients receive organs from her. However it turns out that she didn't die of a drug overdoes, but of rabies and now the other patients have it too. All three die, and while two of them would never have survived long enough to find another donor anyway, one could easily have held on long enough if they hadn't been infected. Truth in Television: This episode was based on a real case.
- The Serial Killer of the Week in the Profiler episode "Dying To Live" murders people with a rare blood type in order to help people with that blood type in need of organs.
- On Psych, someone kills a number of people on the regional liver transplant list, in an apparent attempt to move their own name to the top. It was a case of Artistic License - Medicine, as the woman in need of the transplant has an identical twin, who should've been able to voluntarily donate a liver lobe to her sister without recourse to the donor list.
- In one episode of Babylon 5 Londo ends up needing a blood transfusion, but has a very rare blood type. He is saved by a transfusion from his wife Timov (Who stated that blood type was the only thing they had in common). While she gets Dr Franklin to promise to not say where the blood came from, the novels about Londo's reign as Emperor state that he eventually figured it out.
- On Leverage, The Cross My Heart Job features a rich businessman who attempted to steal a heart that was intended to be transplanted for a teenage boy. Unfortunately for him and fortunately for the boy, Nate and his team find out about this and are able to recover the heart. It is interesting due to the limited amount of time that the team has to work with.
- Forever Knight did this in season 3. Nick and co are investigating a black market organ ring. Natalie is scheduled for a knee surgery, and has the misfortune to have as her doctor who's connected to it somehow and who's the mother of a girl who needs a heart transplant. She nearly ends up an unwilling donor, but Nick gets there just in time.
- General Hospital: Seven year old B.J. Jones was left brain dead after her school bus crashed. Her parents, Tony and Bobbie, took her off life support and donated BJ's heart to her cousin, Maxie, whose heart was failing. The story won much critical acclaim and is regarded as a ground-breaker and one of the best stories to date. It can be viewed here.
- 30 Rock gives us the entire episode "Kidney Now!", in which Jack Donaghy, having found his biological father Milton Green, discovers that Green needs a kidney transplant. Since he himself is incompatible, he organizes a benefit concert by blackmailing a bunch of celebrities to sing on national television in the hopes that it might convince someone to donate a compatible kidney.
- In Curb Your Enthusiasm, Richard Lewis is in need of a kidney. Larry and Jeff find out that both their kidneys are compatible and compete to see who will give the kidney. Larry ends up giving it in the season finale.
- In Soap Danny gets shot through both of his kidneys protecting his girlfriend/police witness. Mary, his mother, can't give him one so his brother, Jodie, offers his up except Mary is forced to reveal that they aren't full brothers and that Danny's real father is actually Chester, who Mary convinces to give up a kidney.
- "The Goldberg Variation" of The X-Files has a boy whose liver doesn't work well (Scully diagnosed him just by looking at him), and he needs either a transplant or to get in a special treatment program in England. He's got a rare blood type and further complications. He makes it through. The Mafioso of the week was a perfect match and got killed near the end of the episode.
- It happens quite a lot on Monday Mornings with interesting twists. Dr. Tierney's transplant programme is in the centre of attention as much as the brilliant neurosurgeries, which appeared to be the show's main hook, apart from the M&M meetings (M&M stands for morbidity and mortality).
- When a young gangster dies, his organs are harvested and transplanted to various people. The drama lies in Dr Tierney's insensivity. He spoke about it in front of the dead kid's mother without knowing who she was. When he tried to apologise, he unfortunately insulted her and hurt her more by implying that her son's life was worthy only because he enabled several people to live.
- One episode had a scheduled operation for kidney transplantation. A young women agreed to give up her kidney for her sister's benefit. The sister who was to receive it dies during the operation. Naturally, they assume someone else could get it, but the woman wants it back, and um, she wants to eat it. She's sane, it's just that her grieving rituals are not western.
- A young man is badly hurt and everybody assumes he was a jumper. They are reluctant to treat him, but they do. He might end up a donor but they actually need organs for him. The team's attitude change when they find out that he didn't try to commit a suicide but somebody pushed him. Dr. Hooten calls them on it during their "screw-ups meetings", and is extremely harsh on them because suicidal people are considered ill, and they are not losers unwilling to live.
- One woman who is brain-dead signed that she's a donor, but her son doesn't want her organs to be used. They want to legally stop the transplantations and argue that she didn't know what she gave consent to.
- Oz. Neo-nazi inmate Robson makes the mistake of racially-insulting the dentist giving him a gum transplant, resulting in him being implanted with gums from a black man. At first this is Played for Laughs given that Robson is an Asshole Victim, but it quickly becomes Nightmare Fuel once he's thrown out of the Aryan Brotherhood.
- Haven featured someone whose Trouble caused his organs to fail, and thus he would need transplants. He then could steal the organs of his children using an Overly Long Tongue, which also triggers their Trouble if they manage to live. Duke ends up killing him to end the Trouble permanently.
- Martial Law had an episode where a heart intended for a governor's daughter is stolen before it can be delivered.
- As did Walker, Texas Ranger. Though in this case it was a liver, and the ambulance had been hijacked by bad guys who needed the medics to tend to one of their own and had no knowledge of or interest in the organ.
- A final season plotline of ER had John Carter in renal failure due to both injuries he received when stabbed 9 years prior and an infection he picked up while working in Africa. He finally received a kidney towards the end of the season.
- ''Sisters' Big Al, second husband of oldest sister Alex was in need of a donor heart and got one on the day of second-oldest sister Teddy's wedding.
- Jade Empire has a sidequest involving a young girl whose liver is dying, and her father has come up with a way to replace an organ, but he needs a new or preserved liver. Your options are to convince him to use his own liver or to convince a ghost to atone for his sins by giving you his preserved liver.
- The SEGA Shadowrun game has a sidequest in which you must steal a prototype cyber-heart for a mercenary who's body has been fitted with so much cyberware that his regular heart is too weak to continue sustaining him.
- In , Providence convinced Director Erich Solders to betray the ICA in return for a heart transplant, as Soders has situs inversus (all of his organs are inverted when compared to a regular person), he requires an extremely rare "inverted" heart that only Providence can procure (with a shotgun and a beer cooler).
- Batman & Mr. Freeze: Sub-Zero, where Mr Freeze's wife Nora will die without an organ transplant. They get through the movie without ever specifying which organ it is that she needs; it's implied that she needs several. It turns out a compatible donor... happens to be Barbara Gordon aka Batgirl. By the end of the movie, Nora is saved, thanks to Wayne Enterprise assistance.
- One episode of Chilly Beach had Dale's estranged brother show up out of the blue and mention that he needs a kidney. Dale is quite reluctant to go through with it, however, a guy gives him a shout-down for letting his brother die. As it turns out, Dale's incompatible with his brother. Frank, on the other hand...
- One episode of The Simpsons has Grandpa's kidneys burst, and he eventually wheedles one out of Homer. It's lampshaded that "You've dramatically shortened your lifespan so someone else can enjoy a few more short years of life." The episode ends with Homer patting one of Bart's kidneys...
- In South Park, Kyle becomes seriously ill when one of his kidneys fails. His mission to get hold of one is hampered by a sudden craze for alternative medicine, leaving all the adults in the town dismissive of his ailment. Worse, the only potential donor with a compatible blood type is Cartman, who takes great pleasure in the idea of watching him die.
- The Venture Bros.: Dr. Venture finds himself in need of two kidneys after he wakes up in a tubful of ice and a kidney-shaped set of stitches in his back. (He ends up taking one from each of his sons, who have been cloned multiple times because each keeps dying in some stupid fashion.
- In one episode of Young Justice, Kid Flash needs to deliver a heart to a dying girl, who happens to be royalty, by running cross country during a massive attack by a group of ice themed villains.
- When NBA player Alonzo Mourning needed a new kidney, he got countless offers from his fans to get a new kidney; Mourning told them to register their names with the Red Cross instead, and is currently lobbying for legislation to make it easier for others to get new kidneys.
- One of those sidebar stories in the Reader's Digest tells the tale of a woman who received a heart transplant and (unknowingly) struck up a romance with the grieving widower, wondering why he'd always caress her chest where her heart lay.