- Molly wrote George a letter to apologize for all of bullying that she and the Tough Customers did to him in the sixteen years since his introduction. George finally caught a break.
- Dr. Fugue tells Arthur's class to perform in the diner they're stuck at instead of the concert that they were preparing for. When they ask why, he says that they worked too hard not to hear how good they sound.
- The entire town pulling together to make it through the blizzard.
- Any moment where Arthur and D.W. act like loving siblings to each other. For all their sniping and arguing with each other, we see plenty of evidence that they genuinely care about each other.
- "Arthur and the Crunch Cereal Contest", when Arthur enters D.W.'s song into a contest he wanted to win. Arthur gives D.W. full credit, and she wins.
- A special mention should go to the intro to "What's in a Name?", in which Arthur spent the entire segment with D.W., helping with her little ritual of naming a new stuffed animal she got without complaining. He actually seemed to enjoy it.
- For most of "Lost!", D.W.'s distress at the possibility that Arthur is gone forever comes across as her typical drama queen histrionics, but when he finally returns home, the episode's final scene makes it clear that she was truly worried about him and would miss him if he were to disappear.
(Arthur is about to fall asleep when a bright light suddenly shines from his bedroom door)
Arthur: Huh? What's going on? (he sees D.W. standing at the door with a flashlight, which she then turns off) D.W., what are you doing?
D.W.: I'm making sure you're not lost. Arthur, you scared me. (climbs into bed alongside Arthur) You'd better promise never to get lost again.
Arthur: (moving over to make room for D.W.) Okay. I won't.
D.W.: Do you promise?...
Arthur: I promise.
D.W.: Cross your heart?...
Arthur: (sleepily) Cross my heart... (he nods off; D.W. smiles, rolls over, and falls asleep)
- "D.W.'s Time Trouble". After spending the episode dreaming about what life would be like if she were the first born child, D.W. wakes up realizing that she prefers Arthur the way he is as he comes in to give her the toys she left in his room. D.W. then tells Arthur that she's glad he's her big brother as she gets into bed with him.
- There's another heartwarming scene early on. During the dream, DW convinces her parents to take her baby version instead of Arthur. After travelling into the future and seeing her parents have decided not to have any more children, she feels sorry for Arthur, and leaves him on her parents doorstep so that he can have a family. Even in a dream, she loves him too much to be without him.
- In "Never, Never, Never", after the Tibbles have tricked D.W. into giving them her old toys with false claims of love only to begin destroying them, she tries unsuccessfully to get them back. Arthur then enters the Tibbles' house to try his luck, and we hear sounds of a scuffle inside, until eventually Arthur emerges with a box of toys and a broken earpiece on his glasses. During the scuffle, Nadine tells D.W. that Arthur's bravery on her behalf in the face of the twin terrors shows that he really does love her. D.W. decides to repay Arthur's kindness by selling some of her toys to help raise money to fix his glasses.
- David Read: "Spanky, I'll always remember the time you got loose in my kitchen, and you didn't eat a single poppyseed. Thanks." Coming from a caterer, that's huge.
- After everything neat that Buster has seen and done on his trip with his father, the first thing that he wants to do when he gets home is play checkers with Arthur. They pick up right where they had left off.
- In "The Great MacGrady", Mrs. MacGrady is about to clean up a mess that D.W. accidentally made while she, Arthur and Muffy were visiting. Upon noticing that the cancer has made Mrs. MacGrady rather weak, Muffy, of all people, immediately stands up and offers to clean it up herself.
- The episode where Arthur cuts his knee on a tin can lid while finding a wheel in the junkyard for his school project, where D.W. and Brain show genuine concern for his well-being.
- The entire Crossover episode featuring Mister Rogers.
- A bit of an overlooked one in Bleep. When D.W. hears a teenage boy utter a swear word censored by the titular bleep, his mother drops a drinking glass. D.W. is curious about what the word means and is about to ask Grandma Thora, but has an imagine spot where she says the word and causes Thora to drop the glass bowl she just bought at the store.
- The ending to "Portrait of the Artist as a Young Tibble", in which the Tibble Twins realize that they like painting more than the toy they spent the whole episode raising money to buy and sell said toy to Binky so they can have money for more painting supplies. The Cold Open even implies that they grow up to be famous artists in the future (granted, with an unconventional approach to their craft).
- Regardless of your feelings about the tantrum, when D.W. calms down and accepts Quackers as being "kind of cute for someone who's not a kitty."
- The relationship between Molly and her little brother James. It's obvious that she adores him and she's always willing to listen him and give advice when life seems to be going wrong for him.
- After nineteen seasons of fearing and bemoaning Mr. Ratburn, Arthur and his classmates decide that they actually want him back for 4th grade.
- It's short and ironic given what happens later in the episode, but the fantasy sequence of Muffy and Francine as little angels twirling around side-by-side in "Arthur and the True Francine" is insanely adorable.
- Muffy's friendship with her butler, Bailey is actually quite sweet, especially considering how spoiled rich kids are usually depicted as treating their staff. In one episode, it's shown that she likes him enough to buy him a birthday card with a really sweet little poem in it ("Who says that good help cannot be found? Thank you so much for driving me around!"). And the feeling seems mutual, as Bailey always sticks by Muffy and helps her out when she needs it.
- Even though David and Jane Read make the better part of their money in the service of the Crosswires, the Crosswires don't look down their noses at the Reads, and the two families enjoy a good friendship. "Arthur's Birthday" might be one of the best examples of this, and it comes early on in the series.
- "Shelter from the Storm" - Muffy meets a new friend at the shelter where her family stays when part of their home is flooded. Muffy is telling her friend how she misses all her luxurious stuff—but then is invited to see the other girl's house. When Muffy learns her friend's home has been destroyed, she is genuinely touched and selflessly offers to let her friend's family stay with the Crosswires. Granted, the girl politely turns her down because she is going to live with her uncle, but still a very sweet moment.
- "The Last Day" has a huge one. Arthur and Buster have spent the entire episode trying to ensure they end up in the newest teacher's class for fourth grade, because he appears to be a Cool Teacher. However, they eventually learn he is more of a Hippie Teacher with tired material. This inspires Arthur and Buster to reflect on how much Mr. Ratburn really taught them. They end up giving Mr. Ratburn the poster they worked hard on for the other teacher. Their choice is rewarded when Mr. Ratburn is not only moved, but announces he'll be moving up to fourth grade. Extra points because this also means that Binky, who was held back the year before, passed and gets to go to fourth grade with his friends.
- It's very sweet to see Binky and DW bonding in "The Chips are Down".
- At the end, at the ballet concert, Arthur, Francine, Buster, and the Tough Customers tell Binky he was the best part. In fact, Rattles is the first one to say it.
- In The Pageant Pickle, Jane forces Arthur to attend D.W.'s preschool pageant. Not only is this something Arthur doesn't want to do, but the pageant is on the same day as Muffy's pool party. Muffy decides to start the party after the pageant ends so Arthur won't miss out. Very nice since Muffy is under no obligation to change what time her party starts.
- Towards the end of Locked in the Library!, Arthur thinks Francine is in trouble and comes to rescue her. When he finds out she's perfectly fine, he says "Don't scare me like that!" They start to fight, until...
Francine: Wait a minute! You were worried about me?
Arthur: Of course!
- Anything involving Muffy's friendship with her butler Bailey. In most cartoons, the rich kid would be no end of trouble for his/her servants, but Muffy is shown to be very kind to Bailey, and Bailey in turn is shown to be practically a second father to Muffy, as well as something of a confidant to her. In one episode, she even buys him a sweet birthday card (with a little poem that goes "Who says good help cannot be found?/Thank you so much for driving me around!").
- Most of "Operation D.W." qualifies. When Arthur finds out D.W. is having surgery, he goes out of his way to be nice to her, bringing her snacks, letting her have the last coveted pizza roll, and agreeing to see a girly movie she wants to see. He also calls his little sister brave and gives her a good luck mark from his lucky pencil. Arthur and D.W. also talk amicably about the excitement and newness of her doctor's appointments (like when she learns how to say "anesthesiologist.")
- In Carried Away, Pal's cousin Dr. Yowl takes Pal, Kate and Mei Lin throughout the solar system and stops at Pluto where Pal's relatives have a family reunion. Once they return home, Kate says Pluto has everything Pal wants. Pal agrees that Pluto does have everything he wants...except for Kate.
- Linda realizing just how important Hobson is to Arthur, asking if she may kiss him on the cheek.
Hobson: Is it important to you?Linda: Yes, yes it is.