The Venture Bros.
- # 21 and # 24 . In "The Lepidopterists", they are well aware that they posses the perfect combination of "expendable and invulnerable". Upon being sent off on a mission with # 1, they remark that his cool professionalism marks him for death, while their bumbling incompetence will see them through to the end. Later, when they point out that # 1's lack of a name makes him a Red Shirt, he reveals his name, only to have it dismissed as a device to make his impending death more emotional. Ultimately, he meets his fate when his impressive escape techniques draw the attention of Brock Sampson. # 21 and # 24 were pretending to be wax sculptures at the time. Ironically, or at least in a cruel twist of fate, in the season 3 finale, 24 stands near the Monarch's car when it suddenly explodes. He's killed in the blast as 21 unintentionally catches his burning head.
- Dr. Venture spends half the time making sarcastic genre savvy comments. Brock does it a lot too, especially when they're in danger. Come to think of it, a great deal of the cast are.
Dr. Venture: This is gonna be one of those things, isn't it?
Dr. Venture: I mean, you get a bunch of short-fused, costumed idiots together in one room like this, and what do you think's gonna happen? Any minute now, stuff's gonna start blowing up, guys'll be throwing each other at other guys.
Brock: Yeah, probably.
Dr. Venture: You know, when you're not the one in the middle of it all for once, it's actually totally, completely obvious.
Brock: Welcome to my life.
- Hank and Dean aren't. They think they are, though, with all their presumed Hardy Boys style mysteries. This occasionally works out for them, one example is in the episode "Fallen Arches" when Triana Orpheus is kidnapped by the super villain Torrid and Dean thinks to run the hot water in the shower so the steam will reveal a message on the mirror.
- Discussed in this exchange:
Lisa: This broom closet is not what it seems. It's a secret surveillance room guarded by a tiny evil robot!
Homer: Ugh. Is this gonna be like one of those horror movies where we open the door and everything's normal and we think you're crazy, but then there really is a killer robot and the next morning you find me impaled on a weather vane? Is that what this is, Lisa?
- Played straight when there's an episode where Homer becomes an opera star and someone is trying to murder him (long story). To protect him during an opera performance, Chief Wiggum orders the hanging chandelier to be ''pre''-crashed instead of crashed.
- Lisa manages to apply it to real life in a somewhat rational fashion, as she plans to be a jazz musician who is unappreciated in her time but discovered as a genius decades later. "And I may or may not die young, I haven't decided yet."
- In ''Treehouse of Horror IX", Bart and Lisa are trapped in Itchy & Scratcy's universe and are inside a car about to be murdered. Bart uses his cartoon knowledge to draw an eject button, press it and escape.
- Homer applies a bit of genre savviness to help Apu and Manjula get pregnant by setting them up in a scenario with every cliche in the book of the Law of Inverse Fertility.
Homer: Now, this situation is guaranteed to end in pregnancy.
Apu: I'm willing to play the high school jock but did you have to cut the roof off my car?
Homer: Ah bup bup bup bup! That's an Apu question, you're Greg.
Apu: (reading) Uh, gee Betsy, it's such a nice night. Why don't we go all the way?
Manjula: (reading) But Greg, my dad will kill me! And you have that scholarship to Ivy League State.
Apu: Loosen up, baby. Tomorrow I'm shipping off to Vietnam. I— (breaking character) I thought I was going to Ivy League State.
Homer: My mistake. Stay in the moment.
Manjula: Just promise not to forget me on your dinosaur bone digging up trip.
- In "The Twisted World of Marge Simpson," the Mafia and the Yazuka are fighting on the lawn. Marge thinks that they should go inside.
Homer: But, Marge, that little guy hasn't done anything yet. Look at him. He's going to do something and you know it's going to be good.
- In "Eternal Moonshine of the Simpson Mind," Homer accidentally walks in on Marge and Duffman planning a surprise party for him. Feeling guilty, he decides to take Moe's "Forget-Me-Shot" so it will still be a surprise, but before drinking it, Homer realizes that he's bound to retain some memory of walking in and seeing them, which could eventually drive him to despair at the thought of Marge cheating on him, so he tells Lenny to make sure the party has a moon bounce.