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Anime and Manga
- In Fist of the North Star, the ultimate death of Rei happens in this style, as Raoh struck a pressure point that forces all of a victim's blood out of their body. Violently. It's so graphic even by this series' standards that when he hid in a cottage to finally die, nobody bothered to follow him in, forced to listen a great man dying in such a painful fashion.
- A sign of possession by Satan in Blue Exorcist. I some cases during the anime blue flames also pour from the eyes and mouth.
- Blood from the Mouth is a fairly common occurrence in InuYasha. When Miroku, determined to finish off Naraku once and for all before the fight against him kills Sango's little brother, takes in so much miasma that he starts bleeding not just from the mouth but from the nose, ears and eyes as well, there's no doubt how serious it is.
- In Saint Seiya, this was the effect Shiryu suffered for overusing his Dangerous Forbidden Technique. Luckily his opponent had a Heel Realization and saved Shiryu before he died from blood loss.
- In the Canaan series, this is how the unfortunate people infected with the UA Virus usually die. It's seen in an especially horrifying way when Liang Qi tries to give herself synesthesia via willingly injecting herself with the virus, and soon is bleeding from everywhere while wearing skimpy lingerie...
- This is one of the symptoms of the flesh-eating virus in Cabin Fever.
- Outbreak presents Motaba, a fictional viral hemorrhagic fever. Its symptoms are based on real life diseases Ebola and Lassa fever. All three cause hemorrhaging from bodily orifices.
- The titular technique from Kiss of the Dragon works this way when the needle is taken out.
- In "The Masque of the Red Death" by Edgar Allan Poe, the Red Death, whose symptoms include profuse bleeding all over the face and the body, kills within half an hour of infection.
- In the Dirk Pitt novel Deep Six, a deadly chemical weapon called Nerve Agent S has the side effect of causing victims to do this before dying.
- Let the Right One In: Eli when she enters a building without an invitation.
- Journey to the West often uses the expression "he bled from all the seven orifices". Usually is a result of some unlucky soul getting smashed by Sun Wukong's cudgel, in one occasion or two it was from the monkey itself, due to an incredibly inhuman physical effort (namely trying to not get crushed flat by three mountains which were summoned on his back).
- In the Tamora Pierce The Circle Opens quartet, reference is made to the "blood plague" that helped to bring down the Vestigial Empire predating the nations on the Pebbled Sea. People would bleed to death through the pores of their skin.
- The medical novel The House of God has a former physician die of leukaemia. This happens to him when there are no more platelets left to help him clot. "Oh God, this is awf..." he begins, but he can't finish for obvious reasons, and no orifice is spared.
- In his Memoirs, General Marbot relates how he was stunned by a cannonball during the battle of Eylau; the ball had "only" struck his hat, but his whole head endured the impact because of the solid strap holding the hat in placenote . Blood started to pour from his eyes, ears and nose, and he remained fully aware but paralysed while a desperate fight was raging around him. And then it got worse...
- Averted in "The Emigrants". During the crossing of the Atlantic Karl Oskar is woken by his son to find Kristina bleeding out of every orifice due to scurvy. He believes she will most likely die and spends the night keeping watch over her, eventually succumbing to sleep. When he wakes in the morning Kristina has made it through but another woman in their group has died of the same illness during the night.
- This is how Lu Meng dies in Romance of the Three Kingdoms. He suffers a massive hemorrhage brought on by being possessed by the vengeful spirit of Guan Yu, with the book noting that he died of 'bleeding from the seven bodily orifices,' which is both a pretty visceral mental image and especially horrifying if you're aware that many anicent Chinese scholars technically did not count the eye sockets as bodily orifices.
Live Action TV
- The Hands of Blue from Firefly kill people like this using a small pen-shaped ultrasonic weapon. It's officially stated that it causes bleeding from every orifice in the body.
- A few episodes of the 90s FOX TV show Millennium featured a super-plague like this, where the symptoms went from headache to bloody puddle in less than 5 seconds.
- Murdoch Mysteries: A young woman's body was found ditched in a river and it appeared that her blood has been drained. The team found out that she was pregnant and tried to induce a miscarriage by eating insecticide, and combined with some strange oil and pills, it did induce the miscarriage, but it also caused severe bleeding from her eyes, ears, nose, mouth, nails, and down there... She died an agonizing death.
- Occurs often in Supernatural usually to show that victim of the week died from a supernatural cause.
- On Being Human (US), drinking the blood of a werewolf makes vampires bleed from all their orifices. The blood of humans infected with a certain strain of the flu has a similar but more pronounced effect. Exposure to the former helps Aidan survive the latter.
- In Game of Thrones, when King Joffrey drinks poisoned wine, he leaks blood from his nose and the whites of his eyes fill with blood. He also appears to hemorrhage beneath the skin.
- The virus that the Grounders use as a biological weapon in The 100 causes this.
- Symbaline blood burn does this to a Red Shirt on Star Trek: Enterprise.
- In Homestuck, poor Sollux endures this twice: first when he's killed by the Vast Glub, and later when he hurls the meteor towards the Green Sun and overexerts his psychic powers. Since his blood is yellow, Karkat describes him as looking like "a packet of nasty fetid mustard."
- In Drowtales particularly nasty applications of empathy are shown to be able to do this, first by showing Ash'waren subjecting a Sharen to this, and later Yuh'le demonstrates her unique sorcery that mixes empathy with Blood Magic.