Most of the protagonists in the Whateley Universe grew up reading Marvel Comics and DC Comics, and watching lots of anime, so they're pretty well suited to be growing up as mutants in a superhero universe. Deadpan Snarker Phase is probably the most genre savvy of the group. although they all get into the act sooner or later, even the Cloud Cuckoo Lander Jade.
On the other hand, some of the villains are get a piece of this, too. most notably Mimeo, whose basic MO was worked out decades ago and still remains almost unbeatable, in part because he goes out of his way not to make too many waves. Anti-Villain Jobe Wilkins tends to be Genre Savvy about everything except his own gratingly egotistical personality, which is what usually gets him (sorry, her) in trouble in the first place.
Deconstructed in Sonny Gets Mad Scienced. For all his knowledge about his situation, Sonny's Genre Savvy doesn't actually help him escape. He just happens to be the lucky person on whom the Mad Scientist's experiment worked. Reconstructed when he knows exactly what to do with the henchmen and the scientist when he gets free.
In Survival of the Fittest, v4 character Bounce had been a massive fan of the series prior to her own involvement in it and as such references things like The Power of Friendship never working in SOTF and the fact that, as an unfit, unpopular nerd, there's no point in her making plans because people like her never stand a chance.
In We Are Our Avatars, Awe Striker and Ozbourne, due to being humans from worlds very much like ours, often have familiarity with the fictional universes that many of the other characters come from. This is fairly common amongst most Author Avatars, but a lot of other characters happen to be as well.
This is the source of most of the jokes in the X-Men Flash cartoon "Dark Phoenix Rising". Cyclops references Jean's habit of constantly returning from the dead, the need to put Wolverine on every X-Men team possible and the fact that another group of villains will likely attack while they're being distracted with Dark Phoenix. In "Death Becomes Them", Kitty Pryde asks if the team is counting alternate timelines when they discuss which of them have died and come back to life.
In "84 Egg Sandwich", the employee manning the drive-thru station figures out that the people (Harvey and the gang) are ordering something for an Epic Meal Time project because of how much they're buying.
62. It is better to beg forgiveness than to ask permission, no longer applies to Specialist Schwarz.
87. If the thought of something makes me giggle for longer than 15 seconds, I am to assume that I am not allowed to do it.
Ani Mae, a superhero from the Global Guardians PBEM Universe, whose powers stem from the fact that she's the real life incarnation of an anime Magic Girl, has Genre Savviness as one of her superpowers. Knowing that she is essentially a living cartoon superhero, she's very good at predicting what the villains will do next, because she knows what cartoon and comic book supervillains do.
The hosts of Eat Your Kimchi, Simon and Martina Stawski are savvy with both North American and Korean popular culture.
Darcy in The Lizzie Bennet Diaries. He's savvy enough to ask if he's being recorded when his sister calls him. He knows she's doing a series of demo recordings of their new story-telling application. He promptly ends the conversation when the answer is yes.
The Autobiography of Jane Eyre: Jane is genre-savvy from the start. She seems to know that she is in a dangerous situation and tries to deal with it as best as she can. However, she's lonely and doesn't have a good family or any close friends, so she must go with living at Mr Rochester's house. She uploads her video because she wants advice and feedback from her viewers (in-universe, her viewership is much smaller than in reality). She mostly expects people to be abusive to her, and some of her videos are meant as a piece of evidence if anything serious should happen.
Gaea has shown signs of this a couple times in Noob.
When she has a rare fight against someone towards whom she has a personal grudge, two of her guildmates offer to help and she refuses. However, when one of them says "Well, we might as well leave" Gaea has them stay in case she ends up needing help after all.
She later says that she would never let a rematch happen after winning a duel.
SeaNanners is very good at both working out who the traitor or murderer is in Garry's Mod/Trouble In Terrorist Town, and also at picking off innocents when it's his turn to be evil. He, in turn, gets hit by this a lot in those games, owing to his devious behaviour and the "Never Trust Nanners" meme that spawned as a result.
Daithi De Nogla has a few examples, including the aforementioned "Never Trust Nanners" meme. Upon running into SeaNanners in Murder, he's immediately suspicious.
Jayuzumi both displays this and gets hit by this in equal measure. On his end, he knows just how to piss certain players off enough for them to entertain him and the viewers. The players he interact with show this from time to time as well, with some immediately muting him after advising others to do the same, while others realise instantly that he's using a soundboard.
Hat Films are aware that any mention of "Geoff" (the silverfish that constantly annoys them) probably won't end well. Similarly, whenever something gets set on fire, they often blame Smiffy.
Some contestants from Kawaii Vinnys Minecraft Survivor are prone to being this. The most notable example was Epic_Duck3 (now known as EpicsAdventure, the host of Epics Gameshows) in Season 6 who managed to guess who was with who on the other tribe as well as how others were probably thinking due to knowing them from previous games.
DeviantKyle, a returnee, from season 6 knew two-time finalist, AlcoholicRobot, better than anybody else due to playing with him in two past seasons and knew how strong he really was and warned others about him.