The scene in Crash Twinsanity when Doctor Cortex's whole body (including his head) is stuck in a pipe. Normally, fart jokes are considered the lowest form of humor, but the comedic timing and his squeal make for Grade-A humor. "The greatest evil scientist in the world... stuck in a pipe. How can things get any worse? {farts} {anguished squeal}
The enemy on the first level of Twinsanity that is sick of going back and forth for ten years, and stands up sulking with his arms folded.
One of my favourites comes from the third game: in the level "Double Header", there are double-headed giants. They can hit you with their clubs. Know what happens when you get hit? Crash slams into and slides down the screen!
N. Gin's scene in Crash of the Titans, where he starts arguing with himself (a clear reference to Gollum):
Most of the things that N. Gin randomly yells out over his intercom in Titans:
I'll ruin you like I ruined my prom!
I could be on Cyborg Idol if that show existed! WHY DON'T THEY MAKE THAT SHOW?!
Attention disgusting monkeys: Crash Bandicoot has been sighted loose in the facility. Please take a moment to look around your work space. If you find a bandicoot, please DROP! HUGE! BOMBS ON THEM!! CAUSE EXPLOSIONS, AND SHARP THINGS TO FLY INTO THEIR BODIES!!! (crazed laughter)
Tomorrow is "Make Your Child Work In The Corps" Day. Be sure to bring your many rat-like offspring so we can make them do work considered unsafe for robots. Also, please note that Friday is Hawaiian Shirt Day, so try to find a sufficiently tacky shirt. That is all.
This gem from Uka Uka:
Uka Uka: I'll get the last laugh! (Evil Laugh)(Beat) I'm laughing now too, just in case.