Jimmy Chance (Lucas Neff)A dense but goodhearted guy, Jimmy starts off the series with an identity crisis when he realizes how monotonous his life is. He starts searching for his place in the world, never expecting the path his life would take after meeting Lucy. Although previously a slacker and didn't amount to much, he tries really hard to raise Hope right and that honesty and determination has a ripple effect among those around him.
Virginia Chance (née Thompson) (Martha Plimpton)Jimmy's mother, she has worked as a maid for years and is always cleaning houses of people far wealthier than her family. As a result she has a bit of a complex about how others see them, while leading to its own zany adventures it also keeps her away from more inappropriate behavior. She is protective of her family but also very loving.
Burt Chance (Garret Dillahunt)Jimmy's father, they both work in Burt's lawn care and pool cleaning business. He is very friendly and outgoing, always concerned with the well-being of his friends and family. He greatly enjoys the time he spends with his son and tends to find humor and enjoyment in the little things of life.
Sabrina Collins (Shannon Woodward)A girl Jimmy met shortly after he took custody of Hope, her sarcastic but friendly demeanor meshes well with Jimmy's raw honesty. Despite his crush her long time boyfriend prevents anything beyond some mild flirting. When that ran its course she and Jimmy got together and eventually marry, with her adopting Hope.
Hope Chance (Baylie and Rylie Cregut)The show namesake, she grows up over the course of the series. Generally cheerful as most babies are, she is exceptionally smart but some of the family is concerned about her parentage and what that means for when she gets older.
Barbara-June "Maw Maw" Thompson (Cloris Leachman)Virginia's grandmother and the one who raised her (also being Jimmy's great grandmother and Hope's great-great grandmother), the house is actually in her name. She suffers from a combination of memory loss and dementia, which the rest have to deal with on a regular basis. Sometimes a real chore to deal with, but at other times someone who really livens up the room.
Barney Hughes (Gregg Binkley)Store manager for Howdy's, he is Sabrina and Jimmy's boss. Easily excitable, he is often the butt of some prank Sabrina pulls out of boredom.
Shelly (Kate Micucci)Sabrina's cousin, she runs a multi-purpose daycare (children, the elderly and pets) and babysits Hope. Talented with the ukelele, she is always ready with a little jingle.
Frank (Todd Giebenhain)A co-worker of Sabrina and Jimmy, Frank is exceptionally odd and creepy, but he is otherwise a decent guy who befriends Jimmy.
Javier and Marcus (Ray Santiago and Jermaine Williams)Jimmy's longtime friends, they are never seen apart from each other. Still friendly with Jimmy, they aren't seen very often because Hope restricted a lot of what Jimmy was willing to do.
Lucy Carlyle (Bijou Phillips)Hope's mother after a one night stand with Jimmy. She is actually quite intelligent, but a pushover who eventually snapped when she had enough.