- Bizarro Episode: The scenario booklet Orbital Decay, published early in the line's existence, is widely perceived as an unfortunate attempt to get supporting product out ASAP, even though it didn't really fit the style of the setting. It's basically Zombies in Spaaaace, with ropey orbital mechanics. Few fans talk about it much.
- Broken Base: Weirdly, the philosophical question of whether having one's brain destructively scanned and then perfectly replicated in software is a path to digital immortality or an expensive form of suicide that produces a delusional computer program as a by-product seems to get some fans terribly engaged and occasionally quite abrasive. The recurrent and repetitive arguments on the subject on the setting's official discussion boards eventually led to the creation of a special thread, known to fans as "The Sticky Thread of Doom", to which all such discussions are now directed.
- Darkness-Induced Audience Apathy: Sometimes seen as a problem for the line caused by some of the early art, which was heavy on the Body Horror, rather than by the actual setting content.
- Fridge Logic: A detailed hard SF setting which claims to work through its assumptions fairly rigorously is inevitably prone to occasional fridge logic problems.
- Memetic Mutation: In a fine bit of irony, there's a Clippit The Paperclip joke in Toxic Memes.It looks like you're starting a religion. Would you like help with that?
- Moe: Some of the oppressed bioroids may fit this trope.
- More Popular Spin-Off: The setting started as a series of fiction vignettes in Bio-Tech for GURPS Third Edition. The fiction was popular enough that it expanded to a full setting.
- Pandering to the Base: The presence of "Felicia"-series bioroid Cat Girls may be pandering to the furry/anime-fan community.
YMMV / Transhuman Space