- Acting for Two: The roles of Professor Metz, Beverly Carlton, and Banjo are all traditionally played by the same actor, since they each only appear in acts one, two, and three respectively.
- Actor Allusion: Whiteside's friend Banjo refers to Lorraine as "the oomph girl". In Real Life, the curvaceous Ann Sheridan was in fact called "the oomph girl", a nickname she hated.
- Billing Displacement: The film bills Bette Davis and Ann Sheridan ahead of Monty Woolley.
- Playing Against Type: Ann Sheridan, known for playing working-class roles, playing the vain, glamorous Lorraine Sheldon.
- What Could Have Been: Bette Davis convinced Warner Brothers to buy the film rights to the play as a vehicle for John Barrymore, but his alcoholism had left him too ill.
Trivia / The Man Who Came to Dinner