- Actor Allusion:
- When Kaminsky arrives, the message over the radio announces "the eagle has landed". Kaminsky is played by Hector Elizondo, who previously used the same phrase in The Princess Diaries whenever the Queen arrived.
- This is the eighth film featuring Cary Elwes as a doctor.
- All-Star Cast: Obviously.
- Casting Gag: Lea Michele plays one of Jon Bon Jovi's back-up dancers. One year previously she had almost accidentally hit him with her car while reversing.
- Real-Life Relative: Garry Marshall's daughter Kathleen and his sister Penny cameo in the film.
- What Could Have Been:
- The film was initially conceived as a sequel to Valentine's Day but became a Spiritual Successor instead.
- Halle Berry was originally cast as Laura, but had to drop out due to a custody battle with her ex-partner. After the custody was resolved, Berry was recast in the movie in a different role.
- Reese Witherspoon was offered a role but turned it down.
- Juliette Binoche turned down the role of Ingrid.
Trivia / New Year's Eve