- Channel Hop: The series aired on the USA Network while this movie streams on Peacock.
- The Other Darrin:
- In "Mr. Monk and the End", Molly Evans was played by Alona Tal. Here she is played by Caitlin McGee.
- Unsurprisingly, getting back all the actors and actresses who played the various murder victims throughout the series wasn't exactly feasible. As a result, most, if not all, of the victims' spirits at the end are played by new actors and not specifically identified.
- In the Brazilian Portuguese dub, Monk is voiced by Eduardo Borgeth, because his voice actor in the series, Hamilton Ricardo, died in 2015.
- In the series' French dub, Stottlemeyer was voiced by Érik Colin, who passed away in 2013. In this movie, he's instead voiced by Gabriel Le Doze.
- Playing Their Own Twin: Richard Kind plays a pair of twin funeral directors.
- Role Reprise: Héctor Elizondo and Melora Hardin return as Dr. Bell and Trudy, respectively, having last been seen in the series finale in 2009.note
- You Look Familiar: Tony Shalhoub's wife Brooke Adams had a variety of guest appearances on the show and plays a publisher here.
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