In the episode "First Class Feline," Jon, Odie, and Nermal think Garfield has accidentally mailed himself to Abu Dhabi. Jon is desperately trying to stop the plane but doesn't make it in time. As the plane is taking off Jon yells out "My cat!" It even features the same music from the specials that plays when something depressing happens.
Garfield and Jon crying over the revelation that the singing ants are still alive and that their house was destroyed for nothing in "Another Ant Episode".
The poison apple scene from the episode "Snow Wade and the 77 Dwarves", because it was Orson who caused them to not be able to rescue Wade.
It was also sad because Orson just went ahead and put Wade in danger, thinking it all as just a story (even though he should know by now that his imagination comes to life) and didn't even have any regrets about it.
Out of all the characters, Roy was the only one (who was taking this seriously near the end of part two) who seemed alarmed/upset that Wade could really be hurt/dead when Wade wouldn't seem to wake up, after Roy kissed him while the others just looked on curiously.
Wade Duck on the verge of tears in the episode Quack To The Future after Orson yells at him. He definitely becomes a Woobie in that episode
It's always stupid and mean whenever Orson yells at Wade for no reason, especially when Wade's been nothing but nice to Orson, if strange. Even Roy hinted in one episode to pity Wade for that.
Roy running away in "Banana Nose".
Wanted: Wade's fantasy sequence could make some people feel this way-especially younger fans of Wade Duck.