Leonard comes home early to Penny's apartment in secret, but when the cat is out of the bag, Sheldon is not happy. Meanwhile, Howard struggles with his masculinity after he applies hormone cream on his mother's back.
- Acquired Poison Immunity: Discussed.Bernadette: Your skin has been absorbing estrogen. That's why you've been all bloated and moody and a giant pain in the ass.
Howard: But you're full of estrogen and you don't act like that.
Bernadette: That's because I'm a woman. I've had years of practice riding the dragon.
- In Touch with His Feminine Side: Howard, involuntarily, due to the hormone cream.
- Internal Reveal: Leonard finding out that Raj can talk to women; in the commotion of the main events in the episode, the others simply forgot to tell him.
- Take That!: Howard isn't too thrilled at the concept of Superior Spider-Man.
- With Us or Against Us: Sheldon tries to manipulate Amy into taking his side with this when she defends Penny. Her response?