History Main / BizarreHumanBiology

* ''Franchise/StarWarsLegends'': In the novel "[[Literature/DeathStar Death Star]]" Dr. Divini operates on a human male suffering from appendicitis and finds out that the guy also has ''situs inversus'' - his appendix is located in the lower left part of his belly instead of the right.
** Also in the same novel Dr. Divini speculates that Vader had to be encased in a suit with an artifical respirator and artificial limbs because Vader had rare genetic defects that would cause him to reject ''any'' transplanted organs - including those cloned from his own genetic material.

* ''VideoGame/TeamFortress2'': Even disregarding the questionable medical ethics and arbitrary heart and other organ transplants the Medic performs, the Demoman's body is so alcohol-dependent that it can barely handle solid food and will ferment his bone marrow if denied outside sources.

* ''Webcomic/AliceGrove'': Referenced in a conversation between Gavia (a {{Nanomachine|s}}-enhanced cyborg) and Sedna (a SuperSoldier with ''extensive'' modifications, including [[spoiler:[[QuantumMechanicsCanDoAnything quantum entanglement]] [[PoweredByABlackHole with a black hole]] to let her [[NoConservationOfEnergy violate the laws of thermodynamics]]]]):

* In ''Manga/TokyoGhoul'', both humans and [[OurGhoulsAreCreepier Ghouls]] possess structures called Rc cells, which are described as "liquid muscles" and can become as solid as teeth. However, Ghouls naturally have much higher levels of these cells than Humans. By concentrating these cells in a sac-like organ in their back, they can manifest a LovecraftianSuperpower called a Kagune, which is used for hunting and combat. The form it takes depends on the Ghoul's Rc type.

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* ''Franchise/StarWarsLegends'':
** In the novel "[[Literature/DeathStar Death Star]]" Dr. Divini operates on a human male suffering from appendicitis and finds out that the guy also has ''situs inversus'' - his appendix is located in the lower left part of his belly instead of the right.
** On some colony worlds, descendants of the original human settlers would adapt genetically to conditions on their new worlds and become subspecies of baseline humans in the process. For example, on Csilla descendants of the original human colonists eventually started developing blue skin and glowing red eyes, which was believed to have been caused by Csilla entering an ice age and the presence of certain minerals on the planet. Due to all the changes to their biology they became the near-human species called the Chiss.

* ''Wiki/SCPFoundation'': [[http://scp-wiki.net/scp-811 SCP-811 ("Swamp Woman")]]. A human mutated into a TragicMonster, she has an incomplete digestive tract, absorbs nutrients through her skin, and has decaying liquid flowing through her circulation instead of blood. Furthermore, her only method of voiding waste is to vomit. She can also produce a mucus-like substance on her hands which causes unprotected skin to rapidly undergo necrosis on contact, has an undescribed symbiotic species of bacteria in her circulatory system that she uses to metabolize nutrients and can only remove digested food from her body by converting it into tar and throwing it up as projectiles, a method she also uses while hunting.

* ''Machinima/ZsdavAdventures'': In ''A torony'' (''The tower''), Zsdav and Freezzy try to sneak behind the EvilWizard. But he tells them he has eyes on his behind, this freaks them out and they retreat.

** To a possibly lesser degree, the members of Music/TheRollingStones, especially [[Music/MickJagger Sir Mick]] and Music/KeithRichards.

* The titular ''Anime/{{Canaan}}'' has synesthesia, which translates as AuraVision for her. One example has her seeing the bits of code needed to hack a door that a professional hacker couldn't get. [[spoiler: Too bad that hacker was [[BigBad Alphard]]]]
* Souther ([[SpellMyNameWithAnS or however you want to romanize it]]) in ''Manga/FistOfTheNorthStar'' has ''situs invertus totalis'' with dextrocardia (see '''Real Life''' section below) -- and he's found a way to utilise this quirk as his Emperor's Armour, meaning that Kenshiro's first attempt to defeat him fails utterly. Because all of Souther's organs are inverted in his body, [[OrganDodge so are the]] {{pressure point}}s that Kenshiro's Hokuto Shinken style relies on. When Kenshiro learns Souther's secret during their second battle, the Holy Emperor's fate is sealed.
* Hinted at in ''Anime/{{Free}}'', of all shows, with [[AnimalMotifs Rin]] [[ThreateningShark Matsuoka]]. As a child he had CuteLittleFangs, but [[Anime/HighSpeedFreeStartingDays the prequel movie]] shows him with his signature [[ScaryTeeth shark teeth]] by puberty, implying that he either grew a third set of teeth (impossible for mammals, let alone humans) or they somehow became sharp. Oh, and he inherited the condition from his father, but his sister has normal teeth, implying it to be some sort of chromosomal mutation. [[MST3KMantra Then again]], this ''is'' a series where hair can be raspberry-red, blue, pink, or dark green...
* Italy's IdiotHair in ''Webcomic/HetaliaAxisPowers'' is shown in the comic to be an "erogenous zone". It's unclear if the note was referring to his scalp reacting to the hair being pulled, or if he has actual feeling in the hair, but the fandom tends to run with the latter, and usually applies the same principle to the other curl-bearing nations. At least one fic goes to the logical extreme of the hairs being sensitive and has one bleed when severed. Also, Norway's curl actually floats around, detached from his head.

* In ''[[https://www.fanfiction.net/s/3024244/2/Flat-Tire-with-Bad-Guys Flat Tire with Bad Guys]], [[spoiler:[[Manga/RurouniKenshin Kenshin]]]] was revealed to have nucleated red blood cells which could take on the function of white blood cells in a pinch. In fact, any cell could take on any function, if need be. They can form new organs wherever and whenever they're needed. And [[Series/StargateSG1 Jack O'Neill's]] antigens. [[spoiler:It's because he's a hanyou, and {{Youkai}}, in the Urban Legends universe, are a HumanSubspecies created by the Ancients, whom Creator/{{Vathara}} envisions as AbusivePrecursors.]]

* In ''[[http://archiveofourown.org/works/10696920/chapters/23692221 Mission's end, mission's beginning]]'', about one in a thousand human males have a mutation referred to as Rutgers XY- [[{{Hermaphrodite}} the development of female reproductive organs alongside the typical (and functional) male equipment]], theorised to have been deliberately introduced to the human genetic code during the [[Franchise/StarTrek Eugenics Wars]] to allow the supermen to breed with [[HomosexualReproduction each other]] or [[TrulySingleParent themselves]] without having to involve inferior specimens. Not all males actually develop said organs fully, and those that do won't necessarily menstruate, but ([[MisterSeahorse as demonstrated by one James T. Kirk]]) that doesn't automatically mean they're infertile. It's still not as weird as some of the BizarreAlienBiology from the franchise itself.

* While [[Anime/NeonGenesisEvangelion Rei Ayanami]] is {{canon}}ically known to be at least [[HalfHumanHybrid partially human]], the specifics aren't made clear. To compensate, {{Fanfic}}s tend to depict her with either this trope, BizarreAlienBiology, or ''both'', each in various ways. To list them all would be a herculean task, given the size of the fandom; one notably common issue, however, is whether or not she has an S[[superscript:2]] Engine/[[AlternateCharacterReading Organ]], and its exact role in her physiology.
* Speaking of MisterSeahorse, there is the... ''concept'' of Omegaverse. More details can be found on that page, but the least {{Squick}}y explanation is this trope applied to BizarreAlienSexes.
* By virtue of being a HalfHumanHybrid, Ryuuko gets both this trope and BizarreAlienBiology, as seen in a series of [[PhotoComic photo comics]]; ''Sleep'', ''Stasis'', and ''Untitled''. Regular humans don't hibernate but Ryuuko, in this case, does and, when she does, she's AsleepForDays. As we learn in ''Stasis'', her "hibernation spells" are involuntary and, when she goes into them, it's an AndIMustScream situation.
* Peter Watts' ''[[http://clarkesworldmagazine.com/watts_01_10/ The Things]]'' subverts this. The humans in the story are perfectly normal...which is utterly ''baffling'' to the alien. We can't shapeshift [[HumansAreSpecial like all other life in the universe]], we can't truly communicate beyond exchanging grunts, and our minds aren't disseminated throughout all our body cells but left coiled up inside cystic nerve fibers locked within bony cavities. To a creature that doesn't understand the concept of individuality, we're miserable, lonely, barely sapient ''tumors.''

* In the ''Film/JamesBond'' film ''Film/TheManWithTheGoldenGun'', the [[{{Pun}} titular]] man with the golden gun is a ProfessionalKiller named Scaramanga, who aside from using a golden gun and requesting a million dollars for every hit, is distinctively known for having a [[TripleNipple supernumerary nipple]] (see RealLife section). James Bond uses a prosthetic when posing as him to a man who has hired Scaramanga, but never met him.

* The ''Literature/EighthDoctorAdventures'' novel ''The Blue Angel'' features an AlternateRealityEpisode in which the Doctor is [[AmbiguouslyHuman theoretically human]]. He has two hearts, no navel, and an unusual aversion to the cold. It's probably related to the fact that [[HalfHumanHybrid his mother is a]] [[OurMermaidsAreDifferent mermaid]].

* In ''Literature/JanitorsOfThePostapocalypse'', a plague swept humanity, killing most people and rendering the remainder into {{Technically Living Zombie}}s called 'feral humans'. Feral humans have syrupy black blood, feel no pain, have much lower body temperatures than pre-plague humans, and are nearly unkilleable. They're ravenous and most interested in warm-blooded prey but will eat anything, including [[NoZombieCannibals each other if they can't find plants]]. After fifty years, the Krakau arrived and started [[UpliftedAnimal uplifting]] individual feral humans. These "cured" humans, recruited into the Krakau military, are intelligent but less so than pre-plague humans, retain mostly-feral physiology and durability, and are fitted with ports for feeding tubes because one, the Krakau think that human food is gross and two, there's some risk of reverting to a feral mindset associated with eating by mouth.
* "Literature/MimsyWereTheBorogoves": The anatomical doll from the future, presumably of a [[HumanSubspecies future human]], has different organs compared to a present-day human. This includes a shorter digestive tract, no large intestine or appendix, a difference in the aorta, and a network that goes throughout the body, is attached to the lungs, but is not a circulatory or nervous system.

* The Sebeceans in ''Series/{{Farscape}}'' are [[spoiler:[[TransplantedHumans humans descended from]] {{Super Soldier}}s who were genetically engineered by aliens long ago]]. They have improved physical strength and eyesight (humans are apparently practically blind by the standards of other races) but fewer redundant organs and an extreme ([[FateWorseThanDeath seriously]]) weakness to high temperatures. Also, their women can delay pregnancy once an egg is fertilized (until such time as it is convenient to grow the baby), and pregnancy is accelerated once it is actually begun.

* Common in ''VideoGame/MetalGear'':

* In ''VideoGame/ParasiteEve'', the protagonist Aya possesses a more benign/passive form of the "evolved" strain of mitochondria serving as the franchise' BigBad, which are not only ''a self-aware HiveMind'' that can act like TheVirus, they possess actual superpowers, which include SpontaneousHumanCombustion and BodyHorror transformations!
* ''VideoGame/SakuraWarsSoLongMyLove'' reveals late in the game that [[spoiler:Gemini Sunrise was born with two hearts, one of which is tiny and non-functioning. When she was conceived, she was actually originally meant to be born as a set of twins, but she was the only one to be born, having absorbed her twin sister ''in utero''. This secondary heart would go on to serve as the core of Gemini's SplitPersonality[=/=]EvilTwin Geminine.]]

* Similar to the ''Hetalia'' example above, Aoba from ''VisualNovel/DramaticalMurder'' has hair with nerve endings in it. [[spoiler:In his backstory, it's revealed that he was born attached to his twin brother from it.]]

* ''Webanimation/StupidKids'': In ''És mind nekem tapsol'' (''And they all clap for me''), when Boti gets shot in the head, he wakes back up stating that he cannot be killed by a headshot because he has a toaster instead of a brain.

* ''WesternAnimation/{{Futurama}}'': The sewer mutants are a group of humans that live in the sewer, but developed strange genetic quirks (different ones for every individual) due to radioactive waste mixed with the human feces. Among the biological oddities seen in sewer mutants are [[{{Cyclops}} a single eye]], a third arm, green skin, a singing boil, [[WhaleEgg laying eggs]], tentacles, gills, purple hair, and a pig nose.

[[folder:Web Animation]]
* ''Webanimation/StupidKids'': In ''És mind nekem tapsol'' (''And they all clap for me''), when Boti gets shot in the head, he wakes back up stating that he cannot be killed by a headshot because he has a toaster instead of a brain.
[[/folder]]

* ''ComicBook/Batgirl2000'': Cassandra's blood chemistry is so unusual that the government scientist ordered to analyze it thought he was being pranked. This despite the fact that, according to his analysis, she's entirely human from a genetic standpoint. [[RiddleForTheAges The series never explains this]], nor does it explain her seemingly superhuman prowess beyond a vague "gift" inherited from her mother, despite the aforementioned lack of any superhuman genetics.
* ''ComicBook/{{Batman}}'': Killer Croc is allegedly a human who was born with a very rare skin disease, but many artists have started to make him less and less humanlike and more [[LizardFolk reptilian]] in appearance, [[DependingOnTheArtist sometimes]] having a crocodile snout and tail. One writer has {{Hand Wave}}d this as being a mutation in his disease that grants him traits of more primitive animals.
* ComicBook/DoctorStrange still looks human on the outside, but years of exposure to magic has taken its toll on him. He can no longer eat food that humans normally eat for one thing. Most of what he eats and drinks looks like it's from another dimension (and it probably is). Even worse, it tastes as bad as it looks -- Stephen at one point complains that his meal tastes like ''leprosy''. Still worse, Wong notes that even though that kind of food is the only kind Strange's body can accept, eating it will still eventually kill him.
* ''ComicBook/IronMan'': Post-Extremis, it was revealed that Tony had managed to change how his insides were organized.
* In ''ComicBook/{{Mystique}}'', the eponymous shapeshifter is shown to be able to rearrange her internal organs, grow a face on the back of her head, or even grow additional arms.
* ComicBook/PlasticMan is inorganic after his OriginStory; this actually makes him immune to [[{{Brainwashed}} Brainwashing]], since his brain itself is apparently plastic.
* ''ComicBook/UltimateFantasticFour'': Mr. Fantastic's body is an infinitely extensible fluid-filled sack containing, in place of an alimentary canal and other organs, just a squishable bolus of microbes that perform all metabolic functions. It's definitely ArtisticLicenseBiology, though fans chalk it up to RuleOfCool and leave it at that.

* "Literature/MimsyWereTheBorogoves": The anatomical doll from the future, presumably of a future human, has different organs compared to a present-day human. This includes a shorter digestive tract, no large intestine or appendix, a difference in the aorta, and a network that goes throughout the body, is attached to the lungs, but is not a circulatory or nervous system.

* Souther ([[SpellMyNameWithAnS or however you want to romanize it]]) in ''Manga/FistOfTheNorthStar'' has ''situs invertus totalis'' with dextrocardia (see '''Real Life''' section below) -- and he's found a way to utilise this quirk as his Emperor's Armour, meaning that Kenshiro's first attempt to defeat him fails utterly. Because all of Souther's organs are inverted in his body, so are the pressure points that Kenshiro's Hokuto Shinken style relies on. When Kenshiro learns Souther's secret during their second battle, the Holy Emperor's fate is sealed.

* In the ''Film/JamesBond'' film ''Film/TheManWithTheGoldenGun'', the [[JustForPun titular]] man with the golden gun is a ProfessionalKiller named Scaramanga, who aside from using a golden gun and requesting a million dollars for every hit, is distinctively known for having a supernumerary nipple (see RealLife section). James Bond uses a prosthetic when posing as him to a man who has hired Scaramanga, but never met him.

* ''Literature/DiaryOfAWimpyKid'': In "Hard Luck", [[CloudCuckoolander Fregley]] can blow a bubble ''out his belly button''.
* In Creator/GregEgan's novel ''Distress'', one CrazySurvivalist has loaded himself up with so much BioAugmentation to survive any possible apocalyptic scenario that he doesn't even have DNA in his cells anymore. He can also digest tire rubber in a pinch.

* Humans of the planet [[MeaningfulName Covenant]] in Creator/{{Greg Egan}}'s "Literature/{{Oceanic}}", who are descended from a group of transhumans who have since rejected TheSingularity, are not described in too much detail, but the main feature that is [[LikeRealityUnlessNoted different from actual humanity]] is that the male's penis is apparently detachable, and passes to the female during sex, at which point it is grafted onto the female, and the male grows a vagina.[[note]]One would think this would be a recipe for [=STDs=] and organ rejection to spread like wildfire, but this is never brought up.[[/note]] Unfortunately for the readers, they find this out in the middle of a ''[[FanDisservice sex scene]]'', with almost no forewarning, landing the characters straight into the UncannyValley.

* In Creator/AlanDeanFoster's Tipping Point Trilogy, body modification has become basically as easy as getting a haircut. PowerPerversionPotential is rampant.
* In ''Literature/JanitorsOfThePostapocalypse'', a plague swept humanity, killing most people and rendering the remainder into {{Technically Living Zombie}}s called 'feral humans'. Feral humans have syrupy black blood, feel no pain, have much lower body temperatures than pre-plague humans, and are nearly unkilleable. They're ravenous and most interested in warm-blooded prey but will eat anything, including [[NoZombieCannibals each other if they can't find plants]]. After fifty years the Krakau arrived and started [[UpliftedAnimal uplifting]] individual feral humans. These "cured" humans, recruited into the Krakau military, are intelligent but less so than pre-plague humans, retain mostly-feral physiology and durability, and are fitted with ports for feeding tubes because one, the Krakau think human food is gross and two, there's some risk of reverting to a feral mindset associated with eating by mouth.

* ''Situs inversus'' turns up in ''Series/OrphanBlack'', where it's used as the explanation of how [[spoiler:Helena]] [[OrganDodge survived being shot in the chest]]. [[WrongGeneticSex Genetic chimerism]] later makes an appearance in [[spoiler:Kendall Malone, whose two separate DNA profiles were duplicated to produce two lines of clones]].

* TabletopGame/Warhammer40000:
** [[SpaceMarine Adeptus]] [[SuperSoldier Astartes]]. [[LongList To wit they have aside from the normal human organs 19 implanted organs]]: A secondary heart. An organ that increases bone structure and makes their ribcage ''bulletproof''. [[note]]to small arms anyway[[/note]] An organ that makes their muscles grow vastly larger and more powerful. An organ that increases their blood's clotting ability. An organ that allows them to only need 4 hours of sleep and can go for two weeks without any sleep at all. A pre-stomach that can neutralize otherwise poisonous or indigestible foods. An organ that allows them to "learn from eating". [[note]]Four nerve bundles are implanted connecting the spine and the stomach wall. Able to 'read' or absorb genetic material consumed by the marine, the omophagea transmits the gained information to the Marine's brain as a set of memories or experiences[[/note]] A third lung that allows them to breathe in toxic atmospheres and underwater. An implant giving them far-superior vision to humans. An implant that makes them immune to motion sickness and the ability to consciously filter sounds. An implant that allows them to enter a healing coma/suspended animation. [[note]]This can last for a long time, the longest recorded period spent in suspended animation was undertaken by Silas Err of the Dark Angels, who was revived after 567 years[[/note]] An implant that controls the amount of melanin in their skin.[[note]]It also protects the Marine from other forms of radiation.[[/note]] An organ that quickly filters the Marine's blood, rendering them immune to most poisons. [[note]]This emergency detoxification usually renders the Marine unconscious while his blood is circulated at high speed. The organ's everyday function is to monitor the entire circulatory system and allow other organs to function effectively[[/note]] An organ that enhances a Space Marine's sense of taste to such a high degree that he can identify many common chemicals by taste alone, a Marine can even track down his target by taste. An implant that allows a Space Marine to sweat a substance that coats the skin and offers resistance to extreme heat and cold and can even provide some protection for the marine in a vacuum. An organ that allows the marine to [[HollywoodAcid spit a blinding contact poison, the poison is also corrosive and can even burn away strong metals given sufficient time]]. Implants that are the base for the the other organs. [[OverlyLongGag And finally]] an implant that allows a Space Marine to interface directly with his PowerArmor. Many Black Library writers and ''40K'' characters use the term "posthuman" to refer to Astartes for a reason.
** The Primarchs. All of the above? Derived from the Primarchs' genetic material. And they were created from the Emperor's genetic material. While the details of their biology remain unknown, the Primarchs' and the Emperor's superhuman abilities are signs that beneath the surface, their bodies were ''very'' different from the bodies of normal humans. A combination of this, his own psyker abilities, and the Golden Throne (which is falling into disrepair), are probably what's keeping the Emperor barely alive even though most of his body has rotted away after Horus tore him apart.

* A plot-point in the final mission of ''VideoGame/Hitman2016'', titled "Situs Inversus". One of 47's final targets, [[spoiler:ICA Training Director Erich Soders]], was born with the titular condition, causing all of his internal organs to be mirrored. He also requires a heart transplant, and the rarity of his condition has made getting a right-sided replacement heart very difficult. This has made him to desperate enough to resort illegal and immoral means to obtain a replacement heart in time, ultimately causing him to [[spoiler:betray the ICA by selling confidential Agency client and operative information to [[TheIlluminati Providence]]]]. His condition also means that if you find and destroy the donor heart, the hospital will not be able to find another heart in time, thus dooming the target to a slow but inevitable death.

** [[CombatSadomasochist The Pain]] in ''VideoGame/MetalGearSolid3SnakeEater'' uses [[BeeBeeGun weaponized bees]] as part of his [[QuirkyMiniBossSquad quirk]]. One of these bee types are "bullet bees", which are bees which he grows within his body. He attacks with them by spitting them out like bullets at an enemy, which bore into their targets and eat their flesh from the inside out until they are removed.
** Quiet of ''VideoGame/MetalGearSolidVThePhantomPain'' actually drinks and breathes through her skin. Which gives a bit of a justification for [[MsFanservice her running around on a battlefield practically naked]]. If she is completely submerged, however, she will drown just like a plant would, and although you can't use this against her in-game, she can also apparently be killed by being splashed in salt water.
* In ''VideoGame/ParasiteEve'', the protagonist Aya possesses a more benign/passive form of the "evolved" strain of mitochondria serving as the franchise' BigBad, which are not only ''a self-aware HiveMind'' that can [[BodySnatcher hijack their "hosts"]] and act like TheVirus, they possess actual superpowers, which include SpontaneousHumanCombustion and BodyHorror transformations!

* In the ''Enemy Within'' expansion for ''VideoGame/XCOMEnemyUnknown'', you can use [[AppliedPhlebotinum "meld"]] to, much like the Astartes mentioned above, extensively modify your soldiers' bodies. You can give them chameleon skin, two hearts, regenerative bone marrow, leg muscles to allow them to jump like fleas, aim-correcting eyeballs; the list goes on and on...

* In the later half of ''VisualNovel/SongsAndFlowers'', Jazz is revealed to be a genetic chimera and possesses two different blood types. This proves to be a difficult hurtle during [[spoiler: her mother's murder investigation.]]

* ''Webanimation/StupidKids'': When Boti gets shot on the head he wakes back up stating he cannot be killed by a headshot because he has a toaster instead of a brain in ''És mind nekem tapsol'' (''And they all clap for me'').

* ''Webcomic/AliceGrove'': Referenced in a conversation between Gavia (a {{Nanobot|s}}-enhanced cyborg) and Sedna (a SuperSoldier with ''extensive'' modifications, including [[spoiler:quantum entanglement with a black hole to let her violate the laws of thermodynamics]]):
--> '''Gavia:''' ''[Changes her skin colour with a thought]'' I [[spoiler:[[DePower lost my nanotech]]]]. I'm not ''baseline''.\\

* In ''Webcomic/{{Hellp}}'' some people get random non-human features after they die. Can be as small as a weird eye color or as big as an extra set of limbs, and anything in between. Also, everyone has a WoundThatWillNotHeal which doesn't kill them, even though it's possible to die of physical trauma in this version of Hell.
* In ''Webcomic/QuantumVibe'' when Seamus is originally introduced he has some physiological abnormalities due to a botched [[LongevityTreatment rejuvenation]], gigantism combined with a metabolic disorder that made him morbidly obese, nerves in his hair, and the ability to fart at will. He had most of the problems fixed during the Luna arc, though he's still pretty tall.

Maybe the character was born a {{Mutant|s}}, or belong to a HumanSubspecies, or have gone far enough up the EvolutionaryLevels as part of the [[GoalOrientedEvolution goal of evolution]], or underwent ''extensive'' BioAugmentation of the essentially permanent kind... Or perhaps they were even created as an ArtificialHuman from the get-go. The bottom line is, this human character's biology, while not [[BizarreAlienBiology technically alien]], cannot be considered "normal human" by any stretch of the term, be it due to having extra organs (duplicate or not), wildly different biochemistry, abnormal nutritional requirements, or even possessing completely new cellular organelles.

Note that '''not all''' cases of HumanSubspecies, {{Transhuman}}ism, {{Mutants}}, BioAugmentation, etc. lead to BizarreHumanBiology. They are only ''possible ways'' for attaining this trope.

* [[ComicBook/Batgirl2000 Batgirl's]] blood chemistry is so unusual that the government scientist ordered to analyze it thought he was being pranked. This despite the fact that, according to his analysis, she's entirely human from a genetic standpoint. [[RiddleForTheAges The series never explains this,]] nor does it explain her seemingly superhuman prowess beyond a vague "gift" inherited from [[ComicBook/LadyShiva her mother]], despite the before mentioned lack of any superhuman genetics.
* Franchise/{{Batman}} villain Killer Croc is allegedly a human who was born with a very rare skin disease, but many artists have started to make him less and less humanlike and more [[LizardFolk reptilian]] in appearance, [[DependingOnTheArtist sometimes]] having a crocodile snout and tail. One writer has {{Hand Wave}}d this as being a mutation in his disease that grants him traits of more primitive animals.
* Comicbook/DoctorStrange still looks human on the outside, but years of exposure to magic has taken its toll on him. He can no longer eat food that humans normally eat for one thing. Most of what he eats and drinks looks like it's from another dimension (and it probably is). Even worse, it tastes as bad as it looks -- Stephen at one point complains that his meal tastes like ''leprosy''. Still worse, Wong notes that even though that kind of food is the only kind Strange's body can accept, eating it will still eventually kill him.
* Post-Extremis, it was revealed that [[ComicBook/IronMan Tony Stark]] had managed to change how his insides were organized.
* ComicBook/{{Mystique}} is a shapeshifter who has occasionally been shown as able to rearrange her internal organs, grow a face on the back of her head, or even grow additional arms.

* The ComicBook/UltimateMarvel version of [[ComicBook/FantasticFour Mr. Fantastic's]] body is an infinitely extensible fluid-filled sack containing, in place of an alimentary canal and other organs, just a squishable bolus of microbes that perform all metabolic functions. It's definitely ArtisticLicenseBiology, though fans chalk it up to RuleOfCool and leave it at that.

* ''Wiki/SCPFoundation'': [[http://scp-wiki.net/scp-811 SCP-811 ("Swamp Woman")]]. A human mutated into a TragicMonster, she has an incomplete digestive tract, absorbs nutrients through her skin, and has liquid rot for blood. Furthermore, her only method of voiding waste is to vomit. She also uses this to hunt.

** Ironically, it's the ''milder'' versions of this condition that can be life-threatening, such as when a heart that's inverted in an otherwise-normal chest (a condition known as dextrocardia) tries to pump blood into the lungs with its stronger side and to the body with its weaker one, rather than the other way around.

* Souther ([[SpellMyNameWithAnS or however you want to romanize it]]) in ''Manga/FistOfTheNorthStar'' has ''situs invertus totalis'' (see '''Real Life''' section below) -- which means that Kenshiro's first attempt to defeat him fails utterly. Because all of Souther's organs are inverted in his body, so are the pressure points that Kenshiro's Hokuto Shinken style relies on. When Kenshiro learns Souther's secret during their second battle, the Holy Emperor's fate is sealed.

* The title character from ''Manga/SkullFaceBooksellerHondaSan'' can do the typical anime SweatDrop and BloodFromTheMouth, despite ''being a skeleton.''

* The Sebeceans in ''Series/{{Farscape}}'' are [[spoiler: humans decended from SuperSoldiers who were genetically engineered by aliens long ago.]] They have improved physical strength and eyesight (humans are apparently practically blind by the standards of other races) but fewer redundant organs and an extreme ([[FateWorseThanDeath seriously]]) weakness to high temperatures.
** Also, their women can delay pregnancy once an egg is fertilized (until such time as it is convenient to grow the baby), and pregnancy is accelerated once it is actually begun.

* ''Situs inversus'' turns up again in ''Series/OrphanBlack'', where it's used as the explanation of how [[spoiler:Helena]] [[OrganDodge survived being shot in the chest]]. Genetic chimerism later makes an appearance in [[spoiler:Kendall Malone, whose two separate DNA profiles were duplicated to produce two lines of clones]].
* The Zephryians in ''Series/SonOfZorn'' are animated humans. They can mate with un-animated humans and have children. Male Zephryian humans have [[spoiler: two penises, two scrotums and a man-womb.]]
* In ''Series/{{Supernatural}}'' the [[Characters/SupernaturalSpecialChildren Special Children]] develop psychic powers, the ability to kill with a touch, and super strength, after being fed demon blood as infants.

* TabletopGame/{{Warhammer 40000}}:

** ''VideoGame/MetalGearSolid2'': Fortune was born with her heart on the '''right''' side, due to ''situs inversus'' (see RealLife section).

* [[Music/OzzyOsbourne OZZY, the mutant Prince of Darkness.]] Medical Science had no explanation for why he hadn't drugged himself to death many times over. Medical Science decided to investigate. Medical Science found that Ozzy has several genes that allow him to metabolize opiates and alcohol [[ImmuneToDrugs far more efficiently]] than most humans. Caffeine? Not so much!

* ''WesternAnimation/{{Futurama}}'': The sewer mutants are a group of humans that live in the sewer, but developed strange genetic quirks (different ones for every individual) due to radioactive waste mixed with the human feces. Among the biological oddities seen in sewer mutants are [[{{Cyclops}} a single eye]], a third arm, green skin, a singing boil, [[WhaleEgg laying eggs]], tentacles, gills, [[YouGottaHaveBlueHair purple hair]], and a pig nose.

* Hinted at in ''Anime/{{Free}}'', of all shows, with [[AnimalMotifs Rin]] [[ThreateningShark Matsuoka]]. As a child he had CuteLittleFangs, but [[Anime/HighSpeedFreeStartingDays the prequel movie]] shows him with his signature [[ScaryTeeth shark teeth]] by puberty, implying that he either grew a third set of teeth (impossible for mammals, let alone humans) or they somehow became sharp. Oh, and he inherited the condition from his father, but his sister has normal teeth, implying it to be some sort of chromosomal mutation. [[MST3KMantra Then again]], this ''is'' a series where [[YouGottaHaveBlueHair hair can be raspberry-red, blue, pink, or dark green]]...

* ''Manga/MyHeroAcademia'': Quirks have vastly changed the nature of what it means to be human. Not only do most people have some sort of awesome superpower that is tied to some sort of physical mutation (Bakugo sweats nitroglycerin that he can detonate at will, Jiro has organic earphone jacks that she can plug into objects to enhance her hearing or amplify her heartbeat as an attack, Iida has engines in his legs), there are also a lot of physical mutations that seem entirely unconnected to the power. Tokoyami has a bird's head (his power is a LivingShadow), Kirishima has razor-sharp teeth (his power is SuperToughness), and YouGottaHaveBlueHair is even more prominent than normal for anime. Even people without awesome powers are born with some quirk (the protagonist's mother, for example, can make small objects levitate). In fact, being born a {{Muggle}} is considered a rarity.

* Humans of the planet [[MeaningfulName Covenant]] in Creator/{{Greg Egan}}'s "Oceanic", who are descended from a group of transhumans who have since rejected TheSingularity, are not described in too much detail, but the main feature that is [[LikeRealityUnlessNoted different from actual humanity]] is that the male's penis is apparently detachable, and passes to the female during sex, at which point it is grafted onto the female, and the male grows a vagina.[[note]]One would think this would be a recipe for [=STDs=] and organ rejection to spread like wildfire, but this is never brought up.[[/note]] Unfortunately for the readers, they find this out in the middle of a ''[[FanDisservice sex scene]]'', with almost no forewarning, landing the characters straight into the UncannyValley.