Ability over Appearance: Anne Rice openly protested against Tom Cruise being cast as Lestat in Interview With the Vampire but after she saw the film, she issued an apology and praised his performance. Though she did insist that Lestat's hair remain blond in the film.
On the belief that Hollywood would never make a adaptation due to the massive amounts of Ho Yay, the first few drafts of the script had Louis as a woman! Anne Rice's preferred actress for the female Louis? Cher!
Jeremy Irons turned down the role of Lestat. Johnny Depp was also offered the role, but Tom Cruise was chosen as he was considered more marketable at the time.