Breakout Character: After Interview it's hard to deny that Lestat became the main protagonist of the rest of the series.
Critical Research Failure: Louis and Claudia reach Paris in September, 1870 and enjoy Parisian culture and arts, such as the Opera. During the Franco-Prussian War when Paris was under siege for 5 months, and full of solider while the entire population slowly starved.
Fridge Horror: Louis's plantation is burned, he has disappeared, and the slaves are celebrating with torches. It's doubtful anyone will believe that he called himself the devil and freed them before burning the house himself. It's likely that if they are caught, they would be painfully executed.
This was also one of Thandie Newton's first film appearances.
Seinfeld Is Unfunny: Vampires aren't supernatural demons serving Hell, but people stuck in an existential crisis.
Lestat even remarks throughout the film and book about how whiny Louis is.
If you forget works of Polidori, LeFanu, Tolstoy, Stoker, Murnau, and Herzog then, technically, yes.
At least two of the examples above are supernatural demons serving hell, though still manage to make interesting characters.
More like "Vampires aren't old world demonic aristocrats, but angsty New Orleans gentlemen."
There is actually a line by Lestat about the old world/new world aristocracy thing in the first or second book, with the Louisiana planters trying their best to be at the height of modern court manners despite being an ocean away from Paris, while Lestat's family, being old and incredibly powerful feudal aristocracy, behaves in ways that are downright medieval even in the 18th century. Lestat is still very much the old world demonic aristocrat type in the first book.
Uncanny Valley: There is an unwholesome, doll-like quality to the disgustingly-perfect features of our pallid, frozen-in-time protagonists, never allowing you to be completely at ease with them. Thank you, Stan Winston for making this film even scarier!!
Anne Rice took out full page newspaper ads criticizing the choice to cast Tom Cruise as Lestat (she had originally envisioned Rutger Hauer or Julian Sands in the part). Once she saw the movie, however, she did a complete 180.
In particular, it was his size and country boy appearance that annoyed her. Lestat was described as around six feet tall in a time when the average man stood under 5'4". Casting the 5'6" Cruise in the role (with 5'11" Brad Pitt, no less) bothered her. She also felt he didn't have the ability to play someone aristocratic.
A lot of fans were similarly baffled by that casting. After actually seeing the movie, most agreed that Cruise was, if not quite perfect for the role, at least not the train wreck they were expecting.
Antonio Banderas as Armand, an auburn haired vampire turned when he was just 17. The reason given for this change was the large amount of sexual overtones between Louis (an adult) and Armand (an under-aged teenager). However, whilst the rational for an Age Lift is sound, the fact the actor chosen wasn't an adult who resembled the character more is still pretty questionable.