Moonraker: National hero cheating at cards → plot to nuke London with the most powerful missile ever built by said national hero, who is actually an ex-Nazi.
Dr. No: Disappearance of British agent and his secretary → plot by Evil Genius to shut down the missile launches at Cape Canaveral while selling the missile's secrets to Moscow.
Goldfinger: Richest man in England cheating at cards and smuggling gold → absolutely insane plot to blow Fort Knox open with a nuke and steal all the gold. Bond even lampshades this trope at one point in the book, musing how he went from simple investigation to being tangled up in Goldfinger's scheme.
For Your Eyes Only has one in "Risico": Bond contracted to kill famous smuggler → working with said famous smuggler to kill Bond's client, who is a major drug lord.
On Her Majesty's Secret Service: Bond getting kidnapped by Corsican mob boss → scheme to stop Blofeld from devastate England with biological weapons made at a health clinic in Switzerland.
You Only Live Twice: Meeting with MI6 ally in Japan → final attempt to assassinate Blofeld for once and for all.
Colonel Sun: M gets kidnapped → plot by former Nazi and sadistic PLA Colonel to mortar a peace conference.
Trigger Mortis: Going undercover at Nuremberg Rally to protect British racing driver → plot to blow up the Empire State building by South Korean millionaire.
Films
Dr. No. Murder of a British agent → Dr. No's SPECTRE operation to destroy American missiles.
From Russia with Love. Rosa Klebb coerces Tatiana Romanova to defect to MI6 → Elaborate scheme hatched by SPECTRE to steal Lektor decoding machine from the Russians and selling it back to them while exacting revenge on Bond for killing their agent Dr. No.
Goldfinger. Cheating at Gin Rummy, murder of Jill Masterson and gold smuggling → A plot to nuke Fort Knox.
Thunderball. Attempted murder of Bond → A plot to hold the world ransom with two stolen nuclear warheads.
You Only Live Twice. American and Russian spacecraft are stolen → Elaborate plan by SPECTRE to start a nuclear war between the U.S. and U.S.S.R.
On Her Majesty's Secret Service. Ernst Stavro Blofeld claims title of 'Comte Balthazar de Bleuchamp' → Plan by SPECTRE to abduct women from around the world and use them as pawns to spread a dangerous virus that is capable of destroying crops and livestock unless he gets a pardon for his past crimes.
The Spy Who Loved Me. Disappearing nuclear submarines → A plot to start a nuclear war between the U.S. and U.S.S.R.
Moonraker. Disappearance of a space shuttle → A plot to kill all humans on Earth.
For Your Eyes Only. British spy ship containing Automatic Targeting Attack Communicator (ATAC), which controls nuclear subs gets sunk → A plot to steal ATAC for the Soviets.
Octopussy. Smuggling stolen Faberge Eggs and murdering a British agent → Nuclear sabotage, wiping out an American military base along with nearby cities and World War III.
A View to a Kill. A scheme by Max Zorin of systematic doping in thoroughbred horse racing → A scheme by Max Zorin aimed at destroying Silicon Valley (though these two plot points don't directly connect)
The Living Daylights. Faked sniping attack on a fleeing general → Attacks on British agents and an illegal weapons smuggling network in the middle of the war between U.S.S.R. and Afghanistan. The movie, however, also counts as an inversion. The villains are pitting British and Russian spies against each other by trying to convince the former that the latter are targeting them all for elimination - hoping that they will respond by eliminating the KGB director supposedly responsible for the operation. This is being done to protect their scheme of misusing KGB resources to turn a huge profit smuggling drugs and weapons, which the director is on the verge of exposing. It's a serious crime, but nowhere near as potentially destructive as inciting a war of assassins between the KGB and its Western counterparts (which as Koskov said, in the worst case scenario, could conceivably even lead to nuclear war).
Licence to Kill. Felix Leiter gets injured while his wife gets killed → A plot to smuggle cocaine dissolved in petrol into Asia and sell it disguised as fuel to drug lords.
GoldenEye. Theft of a prototype helicopter → A revenge scheme by a traitorous MI6 agent aimed at crippling London with an EMP-based Kill Sat to cover up a massive electronic bank robbery.
Tomorrow Never Dies. An unusually fast newspaper article on a ship sinking → A scheme aimed at starting a war to gain exclusive media rights in China.
The World Is Not Enough. Murder of a prominent businessman → A plot to force a nuclear sub into meltdown, nuke Istanbul, and contaminate 90% of the world's oil supply.
Die Another Day. Rogue North Korean colonel trades in smuggled diamonds for weapons and is presumably killed for it → Plot by said rogue colonel, who is revealed to have been Faking the Dead all along, to use a solar-powered Kill Sat to cut a path through the Korean DMZ, allowing North Korea to launch an invasion of South Korea.
Skyfall: Attempt to recover an encrypted hard drive containing the identities of every active undercover NATO agent goes wrong → MI6 comes under intense government scrutiny for the mishap → An attempt a by rogue agent turned cyber-criminal to destroy MI6 and get his revenge against M for selling him out to the Chinese.
Spectre: Unauthorized mission by 007 to foil terrorist plot in Mexico City → A campaign to shut down the 00-agent section and replace it with an intelligence-sharing program called "Nine Eyes" → The Reveal that said N.G.O. Superpower whom Bond fought against in Casino Royale (2006) and Quantum of Solace was also behind events of Skyfall, hopes to use the "Nine Eyes" program to stop any investigation into their operations, and its leader Ernst Stavro Blofeld is revealed to be Bond's estranged step-brother, who masterminded the tragedies 007 faced since Casino Royale (2006).
No Time to Die: Russian Scientist gets kidnapped → Stopping an assassin's attempt to destroy the world by wiping out half of the world's population with Nanobots.
