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- Can be found disturbingly often in hentai. Even more horrific (when viewed from a non-sexual point of view), is that it more-often-than-not leads to a disturbing mix of Defeat Means Friendship and Stockholm Syndrome, where the raped individual becomes completely loyal to his/her rapist, helping them to commit further atrocities. And this is all done for the sake of helping people masturbate.
- Basilisk: Kagerou was never very stable to begin with, and getting raped and brutally tortured by Tenzen drove her off the deep end completely.
- In the Fullmetal Alchemist 2003 animé, it was implied that Rose was raped by Amestris soldiers. She went mute after that. She does eventually get better.
- Perfect Blue: Mima begins to lose her grip on reality after she is supposedly raped for a film during her new acting career. Or does she get raped? After this scenario is shown, we hear a bell ring and a director yell "Cut!" and the movie continues into more twists and turns.
- Casca went mute and regressed to a childlike state after a horrifying rape at the hands of her former commander turned demon god Femto during the Eclipse.
- Guts is a more mundane/less supernatural example. He Used to Be a Sweet Kid, but now he's a Byronic Hero with some serious issues that also Hates Being Touched. He became this way after he was raped as a kid — exacerbated by the fact that it came about due to betrayal by his adopted father — and it just got worse with the Eclipse where he was forced to watch the above-mentioned rape in circumstances that all but mirrored his own traumatic childhood ordeal. Let's just say that he has all the reason in the world to want Griffith dead.
- Konuma Ryuuko of Wolfen Crest. She's a nymphomaniac middle-schooler with what appears to be profound psychological damage from repeated rapes in her past, which made her a nihilistic sociopath.
- Deadman Wonderland: One of the factors that made Genkaku Ax-Crazy was how he was raped as a teenager.
- In Black Butler II, episode 8 shows that Alois was raped by the former Lord Trancy. It's implied that this helped make him so Ax-Crazy — he's shown to have been a little off-kilter even before the event, having joked about his entire village dying and happily looted their corpses when they actually did, but his violent tendencies and compulsive promiscuity seem to date from it.
- In Black Lagoon, rape and torture is implied to have been what made Hansel and Gretel so Ax-Crazy.
- Something of an unusual case of this trope, as the rape and torture were used more to condition the children than to break their minds. Hansel and Gretel were so crazy because raping, torturing, and killing were the only ways to avoid being raped, tortured, and killed. In a horrifying (but textbook) example of operant conditioning, the constant negative reinforcement led directly to their psychotic behavior. The truly horrifying thing is that this is the natural human response.
- Subverted with Revy. Rape didn't make her crazy, but turned her from an optimistic, religious child to a spiteful, gun-crazy, God-hating, gun-for-hire.
- In Peacemaker Kurogane, Suzu becomes Ax-Crazy and a Depraved Homosexual after an old man rapes him.
- Legato Bluesummers from the Trigun manga is shown to have been raped (possibly numerous times) by the town mayor, or something like a mayor. As you might guess, he's now quite Ax-Crazy.
- Tsubaki Kasugano - The 6th of Mirai Nikki. She was kept as a mix of Sex Slave and puppet leader by a Religion of Evil.
- In Hellsing, Alucard, aka Vlad Tepes Dracul of Wallachia was sexually abused as a child during his time spent as a political hostage for his father under the Ottoman Empire by the sultan. Currently, he's clearly off his rocker.
- In School Days, Kotonoha's mental and emotional breakdown hits her fully after she's raped by her Stalker with a Crush, Makoto's best friend Taisuke.
- In Sakura Gari, a big reason Souma is so messed up and a Depraved Bisexual is because of all the rape and other trauma he endured in his past.
- In Neon Genesis Evangelion, Asuka crosses the Despair Event Horizon and ends up catatonic after her Mind Rape. By Word of God we're supposed to understand that she literally gets raped. Several dubs/scanslations have her actually say "I've been raped/violated!" and "it's raping/defiling my mind/soul!" as she's psychically tortured by the Angel.
- Much like Souma from Sakura Gari above, this is one of the reasons why Gilbert from Kaze to Ki no Uta is so utterly messed up: In his youth, he suffered rape and other kinds of trauma.
- Auguste and Rosemariné (to an extent) as well, as Auguste was raped by his stepbrother and Rosemariné was raped by Auguste when Rosemariné was fifteen.
- Hinako from Bitter Virgin was traumatised by years of sexual abuse at the hands of her stepfather. This severely messed with her mental state and caused her to develop an aversion to men and Hates Being Touched except by Daisuke. She gets better through her relationship with Daisuke.
- In Fushigi Yuugi, both Miaka and Yui experience rape attempts and go through Break the Cutie processes as a result. They also believe they actually got raped at some point and experience significant periods of depression and self-harm as a result.
- In Count Cain, Augusta went insane after giving birth to her brother's Child by Rape and had to be institutionalized. When Cain, not knowing she was his mother as well as his aunt, went to visit her in secret, she freaked out and threw herself out the window. At the end of the series, we learn that this is a subversion. While Augusta really did go insane afterwards, she had been more than willing to sleep with her brother all along.
- Sensual Phrase: In the manga, Aine's raped by a high-ranked executive who had a beef against Sakuya. Poor girl nearly splinters mentally after that.
- Zigzagged all over the place in Haou Airen. Reilan was driven to bitterness and insanity after she gets gangraped by the mooks of her fiancé Hakuron's rival and forced into prostitution, and she gets so broken that she invokes the trope via setting her love rival Kurumi to be gangraped in front of Hakuron himself to specifically mess with the girl's mind. Even when Kurumi is rescued, Reilan uses this as a part of a Thanatos Gambit as well, so she gets broken anyway — but by the end, she gets somewhat better. And also, Kurumi is raped by Hakuron himself in front of a newfound friend... and that friend is the one who goes crazy instead, which leads him to ultimately shoot Hakuron dead.
- A Cruel God Reigns: In the manga, Jeremy is repeatedly raped and beaten by his step-father, Greg Roland, which eventually drives him to tamper with Greg's car, killing him. For the rest of the series, Jeremy is haunted by images of Greg talking to him, leading him to become a drug addict and a prostitute in an attempt to forget.
- Angel Sanctuary: Sevotharte, a.k.a. Lailah was raped by jealous co-workers, which led to... several bits of nastiness.
- Higurashi: When They Cry:
- Tamura from Bokura no Hentai. He's the most unhinged of the protagonists and displays behaviors unhealthy for a 13 - 15 year old. It's shown he has repressed memories of a neighbor who made him crossdress and molested him as a young child.
- Tokyo Ghoul:
- Nutcracker is a promiscuous scantily dressed ghoul who preys on men and women. She once ate a beautiful woman's face and has the standard attack of stomping on a man's genitals and sucking them up. It's implied she was sexually assaulted in the past to get money when we see her thinking "I need money" when looking up at three guys with slasher smiles.
- Tooru Mutsuki is implied to have been raped by his father after he physically abused him by holding his head under water and later Torso as well. The first event is implied to have been the reason Mutsuki decided to live as a male and is why he finds Male Gaze to be disgusting. The second event makes him break down in tears and believe that he's cursed because of him being taken advantage of by men in his life, namely his father and Torso.
- In one scene we see Big Madam fingering Juuzou's mouth while talking about how pretty her "Rei-chan" is and then reaching down to grope his genitals beneath his dress prior to castrating him with a hammer. It's this implied sexual torture as well as confirmed physical that made Juuzou lose his sanity, though he gets better with Shinohara's influence.
- The CSI fanfic "Face the Music" by Elm 22. Granted, part of Grissom's mental affliction was the torture that went with the rape, but the rape still played a big part in the problems he struggled with.
- Light in the Death Note fanfic "Broken"
- Maka and admittedly Soul in the Soul Eater fanfiction "Scars and Stitches".
- Gamzee in Hivefled, sort of. There are definitely other factors involved (such as the non-sexual torture that accompanied it, building up an immunity to sopor slime, and highbloods tending to be a little 'off' anyway), but the rape really isn't helping things.
- Averted in Rosario Vampire: Brightest Darkness Act III. Aside from having to be healed after taking a paralyzing hit to the spine, Tsukune walks away from getting raped by a ghoul-infected Kokoa none the worse for the wear.
- This played with in Gensokyo 20XX, with Ran and Yukari at different points. According to Word of God, this would be a tad downplayed, as Yukari's experiences did have an effect on psyche, as some of her then mental illness did point to that. This was later elaborated on in the Gensokyo Diaries, when she placed in an asylum so she could learn how to readjust and get counseling for her trauma or, as she calls it, "mental difficulties". On the note of the Ran, this subverted initially in that she was almost raped but apparently played straight after she was raped which leave her cataleptic. Later on, played straight, it becomes apparent she is suffering from a form of RTS
- Some fan written sequels for the Axis Powers Hetalia fancomic called the "Financial Crisis Gang-Rape" will explore this, either with the victim (America) turning into an extreme Stepford Smiler, or just becoming flat out Ax-Crazy and taking bloody, violent revenge on his assailants.
- The first part of the Ipseity series has Bucky sexually abused by his captors, which leads to him developing DID, along with a few other mental disorders among the other personalities.
- Very common trait of many a Mary Sue or (less commonly) Marty Stu.
- In the classic silent film The Wind, Lillian Gish, who is already being driven around the bend by the neverending titular wind, finally cracks completely when the bad guy rapes her.
- The sister of the Anti Heroine in the Dirty Harry sequel Sudden Impact becomes catatonic after the two of them are gang-raped.
- Subverted in The General's Daughter. It turns out that it wasn't her brutal gang rape during military school that lead to the late Elisabeth Campbell's Sanity Slippage. The betrayal of her General father, who refused to investigate the crime further because he thought they wouldn't be able to apprehend the suspects and because he allowed himself to be bought out by his own superiors, was the event that broke her mind and sent her into a downward spiral.
- Most Rape and Revenge films, though some victims (like the ones in Torched and Baise Moi) go a bit more violently psychotic than others, their newfound bloodlust not being restricted to just their rapists.
- Elizabeth Hurley's character in My Favorite Martian.
- Some theories about Mulholland Dr. argue that childhood abuse may have attributed to the heroine's high dream of becoming an actress which ultimately ended in failure and depression.
- In La Piel Que Habito, Norma's (near) rape left her in a traumatic state where she wouldn't even recognize her father anymore and which ultimately made her commit suicide.
- A variant in Sweeney Todd: The Demon Barber of Fleet Street: Judge Turpin drugged Barker's wife and raped her. Afterwards, she Attempted Suicide, which likely gave her physical brain-damage and led to her becoming a crazy derelict. The insanity is still causally connected to the rape, but with an extra step in between.
- I Spit on Your Grave: After Jennifer is brutally gang raped it causes her to lose it and get revenge on her attackers by horrifically torturing them to death.
- Averted in Dragon Bones: No rape victim ever becomes ax-crazy, and the fact that Ward's mother is The Ophelia is not only due to (implied) marital rape, but the overall abusiveness of her husband and her own drug abuse that resulted from it. Some people behave in a seemingly irrational way, like Garranon who is in a relationship with a man who is responsible for the murder of his father and his own rape, but apart from such isolated coping mechanisms, the characters get to keep their sanity.
- The Chronicles of Thomas Covenant has this as a major theme. Covenant rapes a girl early in his first visit to The Land, and it haunts him throughout the ensuing stories. Part of the consequences is that Lena (the girl) definitely loses it because of the rape.
- Tender Is the Night: Nicole's sexual relationship with her father when she was a teenager (hence statutory rape) leads to her becoming schizophrenic.
- Speak: The book centers around a teenager named Melinda, who's just entered the 9th grade. She's not exactly the most popular kid in school, due almost entirely to her calling the police at a Wild Teen Party last summer. After the events of said party, Melinda goes from a bright, outgoing, friendly teenager to a bitter, angry, depressed one. Her grades go down the toilet, her parents are alarmed, and Melinda can't find the words to tell anyone what really happened; eventually, she stops speaking almost entirely. The plot mostly centers around Melinda's gradual decline, up until The Reveal of how she was raped by Andy, and then her gradual climb out of the hole.
- Nimue in The Warlord Chronicles wasn't the most stable person around to begin with, but her rape at the hands of King Gundleus pushed her over the edge. When she got over the worst trauma, she was actually grateful in a way, as a great priestess must pass through three severe trials on their path to true power according to her beliefs, and the rape counted for two of them. But it doesn't prevent her from exacting revenge brutal enough to make battle-hardened warriors cringe when she gets Gundleus in her hands.
- In The Perks of Being a Wallflower, Charlie's aunt was raped as a young girl, which led to her having serious psychological issues, which is why she herself molested Charlie.
- Justified in Codex Alera, in which Odiana was driven mad by being raped while wearing a discipline collar just as her powers as The Empath were coming in. Being forced to feel pleasure, both due to the discipline collar and being able to feel what her rapists were feeling broke her mind, and left her the Ax-Crazy Psycho for Hire Ophelia she is today.
- In the second book of The Sword of Truth series, a queen (Kahlan's sister) is left in a prison for a few days with several criminals. She is rescued right before an execution. At first, she's catatonic, then suicidal, then she seems to recover, but ends up incapable of fighting the very enemies who threw her in the prison.
- Zarate Arkham in Daniel Gonzalezís horror novel Un grito en las tinieblas was raped by her father, causing her several psychological problems and was submitted once in a mental institution. This is a major plot in the novel.
- Nadine Cross become catatonic after being forcibly impregnated by Randall Flagg in The Stand.
- Jan from Days of Our Lives was an Alpha Bitch before she was raped. Afterwards, she turned crazy.
- In Oz, Beecher's rape at the hands of Schillinger definitely didn't do any favors for his mental health.
- Same deal with Cyril.
- Adebisi brutally rapes the semi-conscious Schibetta at one point. As a result, Schibetta, traumatized by the rape, begins losing his mind and is transferred to the psych ward.
- "Revenge", the very first story on Alfred Hitchcock Presents, played on this idea without using the R word. A woman already recovering from a nervous breakdown is "assaulted" in her trailer. Her husband looks to avenge her by killing her assailant. One day, she points the man out to her husband, and he does the deed. Then she points to another man, and another, and another.
- Darcy from Degrassi: The Next Generation is date raped at a party and later contracts Chlamydia. Afterword, what was originally an innocent Christian school girl quickly loses her mind and pretty much becomes a ticking time bomb of hell. She slices her wrists, nearly slices her neck (before cutting off a chunk of her hair), and even lies to the school administrators that a teacher who was trying to help her through it all had molested her, resulting in his suspension.
- An episode of Law & Order: SVU (Behave) has probably the most justified version of this ever seen. The victim of the week was an ordinary woman with an ordinary job and dreams and the like until she was assaulted several years in the past by the Villain of the Week. The aggressor was never caught, but she moved on, went to college, and had just about graduated when the same man found her and assaulted her again, having tracked her down using a stolen driver's license he had taken the first time he attacked her. As far as the after-assault investigation went, same result. Far more traumatized this time, she moved across the country, slowly recovered, got engaged, and was just a couple weeks away from being married... when the same man tracked her down again. The stress and trauma eventually broke apart her engagement and the victim became a total recluse, working from home, having groceries delivered, not leaving her apartment more than once a month if she could possibly help it, and basically dealing with a full dose of the most High Octane Paranoia Fuel imaginable... until during the one day she absolutely had to leave her home for something work-related, the man finds her yet again, this time beating her bloody in the process, which is what leads into the start of the episode. As it happens, the villain was a successful travelling executive who had a collection of these women across the country, who used their stolen IDs to track them down and assault them repeatedly until he became the first thing they think of when they wake up and the last thing they think of when they go to sleep, feeding his ego with the idea that every minute of their lives revolves around what he's done to them and what he'll eventually do again. Even for SVU villains, he is quite beyond the pale.
- Brother Justin has this effect on several young women in Carnivŗle. It's implied to be at least partially due to his nature as the Anti Christ, although there are also visible bruises showing that physical abuse is also part of it.
- The Outer Limits (1995) episode "A Stitch in Time", where a woman is raped/assaulted as a teen and grows up to be a mentally-unbalanced scientist who builds a time machine and uses it to go back and execute serial killers before they target anyone. Her ensuing Ripple Proof Memory does not help with her ongoing mental stability.
- In the Three Days Grace music video "Never Too Late", a woman is almost driven to suicide (she works through her issues, though), and we learn that she became that way as a result of possible physical and sexual abuse at the hands of a man in a striped sweater.
- In A Streetcar Named Desire, Blanche's descent into insanity becomes especially evident after Stanley rapes her.