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Anime & Manga
- Venus Wars features a violent sport called Battle Biking, which is kind of like roller derby fought on one-wheeled monobikes. The heroes of the manga and anime, the Killer Commandos team, use their bikes in their first guerilla action against the Ishtar invaders.
Films — Animation
- Bigweld in Robots rides on one giant ball, which makes up most of his body.
- A little hard to see, but M-O from WALL•E runs around on a motorized ball.
- Poet Anderson: The Dream Walker and its prequel comics features plenty of one-wheeled hoverbikes, mostly used by non-evil characters.
- Officer Shrift from the animated adaptation of The Phantom Tollbooth gets around on a wheel that resembles that of a rolling chair, connected to something that looks like a car jack that can be raised to compensate for his height. It's unclear whether this is a vehicle that he is seated on under his long jacket or a part of him or what.
- The Lorax: Ted's scooter has only one wheel, looking like a big ball. This doesn't stop him from doing impressive stunts with it.
Films — Live-Action
- Star Wars:
- One of the bikes in the Mega Race during Spy Kids 3: Game Over is a motorized unicycle with a very high seat.
- Ciaphas Cain: One of the techpriests in Emperor's Finest and Caves of Ice had his lower body replaced with a single wheel. Made even worse by the fact that techpriests have huge metal dendrites attached to their backs and like to replace as much of their body with metal as possible, though Ciaphas mentions that he must have very good gyroscopes to work.
- The Mulefa in the third book of Phil Pullman's His Dark Materials trilogy. They're a race of Starfish Aliens who use a giant round seed as a wheel, and attach it to their two middle feet.
- Piers Anthony's Cluster Series has severl unusual alien physiologies. One of them is the Polarian - a race that travels and balances on a big ball — which makes it a bit easier on the creatures than the usual one wheel design.
- Claptrap from the Borderlands series is a roughly half-human-height robot that gets around this way.
- Some of Dr. Robotnik's robots from the Sonic the Hedgehog video game series are like this. The earliest (and probably most notable) example is Motobug from Sonic the Hedgehog 1.
- The Securitron robots, which form the personal guard of the post-apocalyptic mogul Mr. House from Fallout: New Vegas, look like this.
- Robot Medics in Team Fortress 2 are the only robots in the game to not use legs, instead opting for a single wheel.
- Mega Man
- The helper Wheelie from Kirby Super Star.
- Skylanders has two: The legendary Giant Bouncer and the Swap Force entrant Magna Charge.
- Maestro in Mystery Mountain. He is the only android designed this way; Mrs. Beasley and Eggbert hover and the rest are bipedal.
- Roadkill Rodney, a robotic enemy from the arcade game Teenage Mutant Ninja Turtles and its ports. Not only could it stay upright on one wheel, but it could send out an electric cable to try to zap a turtle. Whether or not it succeeded, it never fell over until it was defeated.
- The obscure video game MoHo had gladiatorial robots with a single ball on which they moved.
- The Stillborn Franchise Defenders of Dynatron City included Buzzsaw Girl, a mutant heroine whose lower body was a buzzsaw that functioned as a wheel.
- In the Super Famicom Product as Superhero game UFO Kamen Yakisoban: Kettler no Kuroi Inbou, riding the Yakisoban Unicycle (a non-action toy in the commercials) provides Temporary Invincibility.
- Star Wars: Droidworks has several locomotion options for wheeled droids, including one that's a non-magnetic unicycle, which is useful for avoiding being caught by electromagnets, and another as a streamlined tricycle.
- The clown of Kick Man rides on a unicycle.
- Mettaton's standard form in Undertale is a rectangular body balancing on a single comically tiny wheel.
- The protagonist of Pokémon Colosseum travels around Orre in a motorcycle that has one wheel in the back, plus a sidecar with...some kind of...hover-thing. Good luck figuring out how this thing works.
- Fenton Crackshell of DuckTales gets around this way as Gizmoduck. Besides the question of how he stays upright, one wonders where his feet go when he transforms.
- The title hero of Snyder-Koren Productions Roger Ramjet has a few episodes facing the Solenoid Robots, all of which balanced themselves upon a single wheel.
- Speedors in Legends of Chima are one-wheeled vehicles that are regularly used for races.
- The Muni Mula men from The Ruff & Reddy Show balance on a single wheel.
- The Adventures of Jimmy Neutron: Boy Genius: Jimmy Neutron designed his android little brother Brobot this way.
- Starting in Season 2 of Code Lyoko, Ulrich has the Overbike (pictured above), which also flies.
- Ogo from Robot and Monster.
- ReBoot: Hack and Slash, Megabyte's minions.
- Buzz Lightyear of Star Command ends by introducing a love-interest for XR: a robotic personality named 42 living inside Star Cruiser 42. By the end of the episode, 42's personality is "surgically" removed from the cruiser and placed inside a short, humanoid, robotic body with a single wheel as its mode of locomotion.
- Spiral Zone had the Zone Rider, a one-wheeled motorcycle used by, well, the Zone Riders.
- The heroic characters in the Poet Anderson: The Dream Walker short have bikes of this kind.
- The unicycle, of course.
- A self-propelled unicycle has been developed. Like a Segway, all the rider need do is lean forward. The unicycle more or less self-balances.
- The Uno-Wheel Motorcycle, the first fully functional one wheeled-motorcycle. Though technically it has two wheels side-by-side, it looks quite close to Code Lyoko's Overbike.
- Along the lines of the Polarian mentioned under Literature the Ballbot is a robot that balances and moves on a single ball.
- The BB-8 droid from The Force Awakens is a practical effect, meaning that such a robot actually does exist in real life. You can even buy your own smaller licensed version.