"You're gonna feel a little pinch, maybe some discomfort around the neck area. But don't worry. When you wake up, you'll have the body of a seventeen-year-old. In fact, you'll have the body of several."This is an Artificial Human, usually but not always a clone, who is created from the combined DNA of multiple individuals. Sometimes the intent was to clone a single individual exactly, but extra genetic samples were added to the mix by accident. Other times, this is done on purpose to give the clone specific traits from each genetic donor. Non-clone Mix-and-Match Men are physically built from parts of other people, literally stitched together. Can be Half Human Hybrids when at least one genetic donor is human and at least one isn't. Can be Mix-and-Match Critters when all genetic donors are non-humans, such as Human Aliens. Obviously more likely to occur in settings where Designer Babies are common. LEGO Genetics are a prerequisite for making these out of vastly different species. Patchwork Kids is when an individual produced by normal reproduction might as well be one of these, and Extra Parent Conception is a variation of this trope where this occurs as part of a normal conception (or as normal as it gets for that particular species).
— Buffy the Vampire Slayer, "Some Assembly Required"
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Anime & Manga
- Cell from Dragon Ball Z. As the name suggests, he was created from the DNA of the strongest fighters to ever set foot on Earth. Which gives him the best traits of humans, Namekians, Saiyans, and... whatever Freeza's race is called.
- Giorno Giovanna from JoJo's Bizarre Adventure. While he's not a clone of anyone in particular, the strange circumstances around his conception gave him characteristics of both Jonathan Joestar and Dio Brando. This is reflected in his name: JoJo + Dio = GioGio. Turns out there's three other men created from these same circumstances, they appear in Part 6.
- Tenchi Muyo!'s Ryoko was made by Washu, then a genetic researcher for the Jurai, hoping to create the daughter she could never have (and that could never be taken away from her like her son had been, sadly it did not work out that way), mixed her own genes with genes from a microbe she'd been studying.
- In the film, Daughter of Darkness, the Big Bad creates an artificial daughter for Tenchi using DNA from his hair and one of her own.
- In Appleseed, the Bioroids were created with DNA from several donors, including the father of heroine Deunan.
- Neon Genesis Evangelion: Rei is formed from the DNA of Yui Ikari and the angel Lilith.
- In UQ Holder!, Touta Konoe is strongly implied to be one of these, being the result of a genetic experiment meant to combine Negi Springfield's enormous magical power with Asuna's Anti-Magic.
- It's implied that The New 52 version of Superboy isn't just Kryptonian and human, but a mix of other alien species.
- According to Harvest in #19 he's "the product of three unique genetic strands". Two of these are Superman and Lois Lane. The third being the son of an alternate Clark and Lois.
- In the previous continuity, he was a mix of Superman and Lex Luthor. This was decidedly not the original intention, but when a fan named Geoff Johns became the book's writer...
- Deadpool probably counts, but he was a normal human before the Mix-and-Match.
- Damage is somewhere between this trope and Designer Babies; his genes were taken from all the original Justice Society of America.
- The Silver Age DC Comics hero Ultra, The Multi-Alien was a man (in the future) who was a victim of four alien criminals trying to create a means to replicate armies of themselves to conquer the universe. He ended up with a freaky composite body and each of the aliens' powers, which he then used to become a superhero. (He later finds a way to switch back-and-forth between human and multi-form.)
- Brianna from Fred Perry's Gold Digger was created with the traits and memories of her two "sisters" in a Freak Lab Accident.
- DC's Composite Superman. Depending which version you're talking about, he has the combined powers of Supes/Bats plus some JLA folks, or the combined powers of a buttload of Legion of Super-Heroes members.
- X-23 is a relatively mild case of this, being primarily an Opposite-Sex Clone of Wolverine, but because the DNA sample used was damaged they had to double up on the X chromosome, resulting in her being female. Some stories also try to Hand Wave Laura's resemblance to Dr. Sarah Kinney, the woman who carried her to term but was otherwise not related to her, by saying that Sarah used some of her own DNA in the stabilization process, which would give Laura genetic parents in the form of Logan's mother and father and Sarah. Regardless of whether this is indeed the case, because Sarah carried Laura to term, Laura does have Sarah's mitochondrial DNA.
- Arnold Schwarzenegger and Danny DeVito's characters from Twins are Designer Babies with combined DNA from six athlete and scholarly fathers.
- The version of Deadpool used in X-Men Origins: Wolverine fits the trope even more so than his comics counterpart, having Wolverine's regeneration, adamantium skeleton, and adamantium katanas protruding from each wrist, in addition to Cyclops's eye-beams, Kestrel's teleportation, and his own superhuman hand-eye-coordination.
- Sid 6.7 from Virtuosity is sort of like this - he was a computer program created from the personalities of 183 criminals (and an orchestra director), which tricked a programmer into placing him in an android body so he could do damage in the real world.
- In Frankenstein, the monster is made up of various spare parts. The Dean Koontz version goes so far as to identify what sort of people his parts came from. The novel gives almost no details about its creation.
- Mel Brooks Young Frankenstein: like the original Frankenstein's Monster, he's built of parts from corpses.
- The protagonist of Cronenberg's The Fly (1986) kidnapped his pregnant love interest in an attempt to merge himself, her, and their unborn child into this trope. It's unclear if this could possibly have worked, but at the time he was so desperate to suppress his transformation into a human/fly hybrid that he wasn't thinking straight.
- In The Fly II, Seth's child has grown up, and reverses his own transformation by using his father's teleporter to steal human genetic material from the Corrupt Corporate Executive who'd raised him as an unwitting laboratory experiment, replacing his hereditary fly genes with human ones.
- "Lazarus" from the 1995 Sci-Fi Channel movie Mr. Stitch is a sort of Frankenstein Monster made from the corpses of eighty-eight people of every race, age and lifestyle, split evenly among gender and given an identity of his own. Things go wrong when it turns out he has Genetic Memory.
- The reason why the title villain in Monster Man is killing and amputating people is because he needs bodyparts to patch up his resurrected brother.
- The creations in Scream and Scream Again seem to fit this trope.
- The Big Bad of Battle Beyond the Stars, Sador of the Malmori, plans to live forever this way, using his torture-surgeon to sever limbs of enemies or incompetent henchman.
Kalo: Remember Bilko? He disobeyed orders, and now Lord Sador's wearing his foot.
- In Animorphs, Ax's human form is one of these. He took DNA from four of the other Animorphs to create his human form, so he wouldn't look like a copy of anybody.
- Specifically, two boys and two girls, creating a result that is regularly described as "disturbingly pretty".
- The Replica series of novels has one of these as the main character, created deliberately to be an ‹bermensch.
- The title character of Robert A. Heinlein's Friday.
- Darci, the protagonist of the sci fi novel Star Split, is eventually revealed to be a chimera, or someone made of multiple strands of DNA. This itself isn't unusual in the far future world where genetic engineering is the norm, but she's a special case.
- In Vonda McIntyre's sci-fi novella Screwtop, one of the inmates of a prison camp is a mixed-race human "tetraparental", which means his genes have been spliced together from four parents, resulting in black-and-beige marbled skin and patches of black and blond hair of different textures.
- In Donald Moffitt's Genesis series, all humans created by the Nar use this as their preferred reproductive method, as the human gene pool is still too limited to allow random breeding.
- Flinx from Alan Dean Foster's Humanx series was conceived via this trope by criminal scientists, who spliced together DNA from dozens of psychically-inclined sources.
- The Igors on Discworld typically have parts from multiple people, and can replace someone else's missing parts as well. (There is also a mention of a Mix-and-Match Horse in Going Postal, as well as Thcrapth the dog from Carpe Jugulum and Patcheth the cat in the 2015 Discworld Diary.)
- Invoked from an alien POV in Perdido Street Station, when an insect-headed khepri describes humans as "khepri bodies with the heads of shaved apes".
- Stanisław Lem's Przekładaniec explores this: in traffic accidents, doctors aim to save as many lives as possible, even if this results in having to mix working part of people (or even animals).
- The title character of Larry Niven's The Patchwork Girl qualifies as the second type. The widespread use of organ banks (and capital punishment by disassembly for them) in the Known Space setting results in many people technically fitting this trope to some extent. She gets that way by being reassembled from the organ banks after first being partly disassembled for those same banks after being framed for a murder. The protagonist clears her, but is too late to prevent her disassembly due to an emergency need for organs.
Live Action TV
- Adam from Season 4 of Buffy the Vampire Slayer was an amalgam of most of the monsters that the Initiative had captured and was taken out by an amalgam of the main characters.
- The Vidians on Star Trek: Voyager are a race of these. A plague has swept through their entire species, forcing them to cannibalize parts from other aliens. The disease adapts so quickly that the Vidians can never stop looking for new parts.
- Doctor Who:
- Max from Dark Angel.
- It's implied that Mr. Spock was conceived in this way. The Expanded Universe novels outright say he was, but as always, there are canon issues with those.
- House had a patient like this. A boy had a few groups of cells throughout his body that were the result of two fertilized eggs fusing together immediately after fusing to the uterine wall.
- In the third season of Haven, Audrey suspects that the Bolt Gun Killer is collecting his victims' body parts in order to build a Mix-And-Match Woman. The killer is actually a Skinwalker and building a customized suit.
- Power Rangers Dino Charge has Curio, who was created from spare monster parts to be friends with Poisandra.
- In Promethean: The Created, all Frankensteins are made from pieces of at least two separate corpses. It's in the name - the first one was that Frankenstein's Monster. Theoretically, any Promethean can be a mix-and-match, but a Frankenstein has to be.
- Magic: The Gathering:
- Goblin Chirurgeon, whose art depicts one of his patients, who appears to include bits of at least four humanoid species.
- Phyrexians, who do this... and a bunch of other Body Horror. Phyrexian Rebirth turns all creatures in play into this.
- Innistrad uses this as the distinction between black zombies, which apply the rotting-reanimated-corpse model, and blue zombies, which are the product of blasphemous Frankenstein-style experimentation rather than blasphemous rituals.
- Agent 47 from Hitman (Chinese, German, Romanian, Russian and South American fathers).
- Liquid and Solid Snake being twins, are confirmed to be part-American, part-Japanese and part-Chinese (or whatever Eva is).
- Emerl from Sonic Battle is designed to combine the movesets and personalities of the people he meets. When the only people he's met are Sonic and Tails, others can't tell if he's being rude or polite.
- A non-genetic example is Ermac from Mortal Kombat, who is made up of the souls of hundreds of dead warriors bound into a humanoid body.
- Drowtales: Rik the half dragon is something of a genetic experiment, and is ostracized by a society as a result.
- Grace from El Goonish Shive is human and also part squirrel, with alien DNA from an Uryuom and a Lespuko (sort of like an Uryuom, long story).
- Unity of Skin Horse is sewn together Frankenstein-style from mismatched parts.
- As is Quilt from Dominic Deegan.
- Baron Wulfenbach from Girl Genius is probably one of these. The family originally had three sons, but following a horrific lab accident two of them disappeared. It's commonly believed that the Baron is a construct made of the salvageable parts of all three. Even more explicitly, Agatha's foster parents Adam and Lilith, AKA Punch and Judy.
- Homestuck: The four main protagonists are all examples, all being made from the combined DNA of their guardians.
- Molly in The Inexplicable Adventures of Bob! was grown using genetic material from many different animals—and some human DNA, taken from her "mother," Jean Poule.
- Nicole from Quantum Vibe is an "osmotic clone" created from the genes of her mother and eleven anonymous donors. Her mom intended to use genes from 2400 people but couldn't get a viable fetus until Seamus (one of the donors and Nicole's employer) suggested using whole chromosomes instead of pieces of them.
- Dr. McNinja's arc "Why a Gorilla?" has the Doctor face off against a three headed 4 armed Gorilla "Frankenstein".
- In Worm, Blasto is apparently capable of creating these, and he attempts to make one out of Myrddin and the Simurgh. Luckily, he fails; the result is nonviable due to the Simurgh's lack of conventional biology.
- Count Driscol, Captain Cedric and Bernard the Guard in Dragomirs Diary were all originally separate people. But when all three were killed (two of them torn in half!), they were secured by a Mad Doctor and cobbled together into a single, hideous creature. (Which, to be fair, can still split into three individuals, and even when they're together the three heads retain their distinct personalities.)
- Gordon of Twig describes himself as a "chimera," a stitched-together child made from approximately twenty-six different people in order to give him the best body possible. He experiences severe phantom pain episodes when his body tries to reject its own limbs.
- Romy from Pinky and the Brain was supposed to be a normal clone of Brain, but DNA from Pinky was accidentally included in his creation, causing him to inherit traits from both mice.
- Serpentor from G.I. Joe was created from the combined DNA of ten historical figures: Julius Caesar, Napoleon Bonaparte, Attila the Hun, Philip II of Macedon and his son Alexander the Great, Ivan the Terrible, Vlad the Impaler, Hannibal, Genghis Khan, and Grigori Rasputin. Dr. Mindbender tried to get Sun Tzu as well, but was stopped by the Joes. Fortunately, that was apparently enough to throw his military competence out of whack.
- Delilah from Gargoyles is a combination of Goliath's current and former love interests, Elisa Maza and Demona - and the point where her creator Thailog's Oedipus Complex officially becomes creepy.
- Long before that, there was Coldstone, a cyborg whose "organic" (so to speak) parts came from three different gargoyles; and the body has all three souls fighting for control. And just to complicate matters, they're in a Love Triangle: a Happily Married couple and an evil male who wants the female for himself.
- The TMNT 2k3 incarnation of the Rat King (a.k.a. "The Slayer") is one of these, using DNA from Bishop, Splinter, among other possible sources.
- This happens in The Secret Saturdays when Zak and his pet komodo dragon and gorilla-cat are combined into one being.
- Robot Chicken brings us the horror of Composite Santa: genetically/visually one-half Santa, one-half Frosty the Snowman. Goku doesn't know what his powers are, "but he freaks me right the fuck out."
- One episode of Adventure Time has the Ice King give up on kidnapping princesses...and instead just steal a bit from a bunch of them, stitching them together into a woman called Princess Monster Wife. Their relationship is oddly sweet, but she is so freakish that Finn and Jake are unable to fight her, and she is so distraught over her appearance (and origin, when she discovers it) that she pulls a Heroic Sacrifice by returning her parts to their original owners.
- Superboy from Young Justice is a clone created from the DNA of Superman and Lex Luthor
- Chimera of this type can occur naturally when two embryo fuse in the womb. One case resulted in a woman whose apparent genome did not match her children's because her salivary glands and ovaries actually had two different genotypes.
- Recently it's been shown that everyone has a slightly different version of Chimeraism occurring from cellular interchanges during pregnancy. Babies pick up a few from mom and mom from the child. However, these are very few.
- In addition to sexual reproduction blending the DNA of two individuals, much of our DNA is in fact viral in origin. These viruses began somewhere else, often in another species.
- Cloned animals are typically a Mix-and-Match of two parents: the animal from which they are cloned (which provides the nucleus of the lab-generated zygote), and the animal that provided an unfertilized egg (which provides the other cellular components). They have the chromosomes of their cloned parent, and the mitochondrial DNA — what little of it there is — of the egg-donor. Averted if the same female animal is used for both.