"This was back in the day when science goo could just do anything! You could make up the most absurd reasoning, that has no scientific logic, but, it's science goo! So it flies."This is any liquid/slime/sludge form of Applied Phlebotinum that causes living creatures that touch it to somehow mutate or transform into... something else. Occasionally, it may need to be ingested (or injected) to take effect, but in most cases it can be easily absorbed through the victim's skin — their own LEGO Genetics will take care of the rest. The goo comes in many forms — it may be toxic nuclear waste, some form of alien bodily fluid, mud from a cursed swamp, or contaminated water carrying The Virus. Once mutated, sometimes the charaters/monsters become Radiation-Immune Mutants in relation to the mutagen, though not always, and repeated exposure can prove increasingly harmful. Common results include Body Horror, Painful Transformations, and Lovecraftian Superpowers. However, it's also a fairly common backstory for non-Squicky superheroes. Differs from Super Serum in that the effects of this are usually unexpected and nearly always unwanted.
— The Nostalgia Critic on TMNT's ooze
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Anime and Manga
- In Kemono Friends, this role is accomplished by the "Sand Star", a mysterious substance that turns regular animals into the humanoid Friends. It can also change the Biomes of a given region and turns inorganic matter into the antagonistic Ceruleans.
- In The Ultraverse, Dirty Cop Frank Hoag is killed in an explosion that showers him in chemicals before his body is dumped in the sewers. The combination of the chemicals and the sewage cause him to transform into the monstrous Sludge.
- In Issue 7 of the Invader Zim continuation comics, Zim's Voot Cruiser crashes on a lifeless planet. Somehow, its spilled fuel mixes with the planet's core and creates a primordial ooze that causes rapid evolution in anything that is exposed to it.
- The "bio-fuel" from District 9 that turns Wikus into a prawn.
- The black goo from Prometheus. It's a particularly nasty and virulent version, a bio-weapon made up of millions of small micro-organisms, and it's strongly implied that even a drop of the stuff would quickly turn a habitable ecosystem into a Death World populated by rapidly evolving flesh-eating nasties, ravenous mutants, and nightmarish parasites. Sure enough, over the course of the film, it mutates an indigenous earthworm into a foot-long cobra-like parasite with acid for blood, Geologist Fifield into an extremely strong, resilient and aggressive space-zombie, and a sort-of proto-xenomorph.
- The Ooze from Teenage Mutant Ninja Turtles II: The Secret of the Ooze, which according to Professor Perry was an unknown mixture of discarded chemicals that was accidentally exposed to a series of radiative waves.
- A squirrel in The Simpsons Movie was mutated in Lake Springfield after Homer dumped an overflowing silo filled with pig excrement into the lake, causing it to become highly toxic. When chased into the lake by a raccoon, the squirrel emerges as a multi-eyed squirrel mutant.
- Nightmare Hour: The titular "Alien Candy" is a bizarre fudge-like sweet that seemingly transforms kids into aliens, yet oddly leaves their newly elected club president unaffected. The stuff really just gives them an excuse to shed their human disguises so that they can entrap and eat the new kid.
Live Action TV
- Doctor Who:
- The slime produced by the Wirrn in "The Ark in Space", which turns humans into Wirrn.
- The slime oozing from the drillhead in "Inferno", which turns humans into Primords.
- In the Seventh Doctor episode "Delta and the Bannermen", even Chimeron baby food turns a regular guy/love interest into a Chimeron—which, fortunately, was the outcome besotted young Billy was hoping for.
- The titular heroine of The Secret World of Alex Mack gains her powers when she is accidentally splashed with toxic waste.
- The so-called 'black oil' from The X-Files: a sentient alien virus that lives in petroleum deposits. It infects humanoids, taking control of their bodies, and is capable of changing their physiology which is apparently how the alien antagonists of the show reproduce themselves. It can transfer from one host to another and protect itself by emitting lethal doses of radiation.
- One form of Phazon in the Metroid Prime Trilogy is like this. Other times it appears as crystals. The mutations it causes appear to be due to long-term exposure to a type of radiation it emits.
- The Potion of Mutation in Dungeon Crawl. Might be a good mutation, might be bad.
- The content of canisters and the Geneforge pool was most often blue, other times green, ochre or magenta, but always gooey and a catalyst for mutation.
- The Mad Lab dungeon in Realm of the Mad God contains pools of green slime that turn your character into a random pet that cannot attack until you step into a pool of blue goo.
- The FEV (Forced Evolutionary Virus) from the Fallout series is first encountered as vats of green ooze, though an airborne variant also exists.
- In a milder example from Fallout 2, walking through toxic waste without protective footwear will cause the player character to grow an extra toe.
- Structure Gel from SOMA is a black, slimy chemical that's a fantastically efficient conductor when used on machines - and also happens to have mutagenic properties that transformed the majority of the PATHOS-II staff into horrible biomechanical monsters.
- Space Quest V: The Next Mutation has Primordial Soup, which was created in a bacteriological experiment gone catastrophically wrong. Infected humans become "Pukoids," who attempt to transmit The Virus to others by vomiting on them.
- Rogue Stormers has the Goop, an oil-like, black, oozing substance that horribly mutates living beings in addition to powering Dieselpunk tech.
- In South Park: The Stick of Truth, the alien goo turns anyone who touches it into a Nazi zombie, complete with the voice of Adolf Hitler.
- Wasted Away has large pools of this nasty stuff dotting the landscape. Sometimes cats like to get high off it, but falling in can do strange things - it turns Gerald and Ez into a massive creature with huge claws, and turns Radon green.
- Wurr has the Black Touch, found throughout the crater; its effects on an entirely normal dog haven't yet been shown, but given that it can make the already-mutated hounds even more so, it likely wouldn't be pretty.
- In this strip of Sinfest, Slick bolts from a mutant creature emerging from a toxic waste pit.
- The Nostalgia Critic also provides an example in the same review that the page quote comes from when he combines what he calls science goo and a jar of Philadelphia cream cheese; and it turns into a 12" talking Dennis Miller doll.
- The plot of The Cartoon Man is set in motion by a jar of black ink "fermented from the ash of the Fires of Flemsigrad" by occultist animator Oswald Sherzikien. It causes anyone who comes into contact with it to transform into a crazy human cartoon character.
- Handwavium has this effect on living tissue; being turned into a Cat Girl is one of the less weird things it can do to you if you aren't careful.
- The Ooze that transformed the Teenage Mutant Ninja Turtles from regular turtles into the awesome ninjas we all know. A common threat in the 1987 first cartoon was Retro-Mutagen Ooze, which Shredder and other villains tried to use to turn the turtles back into their regular non-mutated selves.
- Futurama has a mutagenic lake in the sewers of New New York. It turns rats into flying fish-pigs, and a purple octopus living there claimed to have once been a little blonde girl named Virginia. Sewer mutants are, of course, immune, and so use the lake as a punishment against offensive outsiders.