In the original Austin Powers movie, Oddjob spoof "Random Task" throws his shoes as weapons. When he tries this move on Austin late in the film, he only succeeds in giving the superspy a minor headache, prompting an incredulous response: "Who throws a shoe? Honestly! You fight like a woman!"
Then Austin proceeds to defeat him using a Swedish-made Penis Enlarger!
Night at the Museum II showcases the the usefulness of a maglight, which is actually a common weapon for security guards and other types of people.
The young Jack Carlisle from the film Magic Island once used bubble gum to defeat a land shark, yes, you read that right.
Smith manages to kill someone with a carrot in Shoot 'em Up. TWICE! He even uses one as a trigger finger when his hands are injured.
Teenage Mutant Ninja Turtles features Casey Jones, who has a penchant for sporting goods, including golf clubs, hockey sticks, and a cricket bat.
Twice during the film's climax he manages to use a garbage truck as a weapon. The films drop subtle hints that with his bare hands he's a poor fighter, but if given a weapon he's effectively unbeatable.
Part of Jackie Chan's signature style is finding novel uses for various improvised weapons collected from around the scene of the fight.
The hero of Pootie Tang uses his belt with great effect.
In the Sammo Hung film Magnificent Butcher, Wong Fei Hung fights another kung fu master with ink brushes.
Practically every main character in Mystery Men uses an unusual weapon. Examples include thrown forks, a shovel, a possessed bowling ball, and flatulence. The film also includes a weapon designer who only creates improbable nonlethal weapons.
TRON. Sole weapon: glowy Frisbee. That the user could control its flightpath. And that could chop other characters in half, even split heads (though all we saw were jewel-like bits coming out of the helmet when this happened.
Anton Chigurh of No Country for Old Men has a cattle bolt gun, which uses compressed air to shoot out a retractable metal rod. He apparently uses it because it's good for blowing out locks, and not many people can tell it's a weapon.
Pam Grier as blaxploitation hero Jackie Brown: "I've got a black belt in barstools!"
Both versions of Walking Tall was all about laying the smackdown with a two by four, based on the real life Buford Pusser.
Then there was the guy with the bean bag gun in The Rundown.
In Dogma, a demon gets its clock cleaned with a golf club ... which just happened to have been blessed. Not to fight demons, mind, but to improve a cardinal's golf game.
In The Lord of the Rings, during the attack in Moria Sam manages to use a frying pan to smash the baddies and knock them unconscious.
The famous scene during the Battle of Helm's Deep when Legolas skates down a flight of stairs on a shield while shooting arrows all the way down; when he reaches the bottom he kicks the shield so that it imbeds itself in an Uruk. An armoured Uruk
Granted, the spikes on top of the shields were pretty sharp.
In the movie of Get Smart, Larabee said he was capable of killing people with random office supplies, including post-it notes. He was most likely lying though.
In The Fastest Guitar Alive, Roy Orbison wields a guitar that conceals a rifle.
Among the many knives found in the Joker's pockets in The Dark Knight film, the police also pull out a potato peeler! You may cringe at the thought of how effectively he'd use it. He also makes effective use of a pencil.
The title character of the Japanese splatter film RoboGeisha is proficient in the use of weapons one would not normally expect to be deadly... with the most eye opening example being a pair of fried shrimp.
Microwave Massacre, The Nail Gun Massacre, Woodchipper Massacre, etc.
The killers in Gutterballs dispose of most of their victims with bowling pins, blunt ones for bludgeoning and sharpened ones for stabbing.
In Labyrinth, the goblin guards in the hedge maze sections use small, sharp-toothed critters tied to the end of poles, which bite whatever they are put near.
Jason Bourne. Pen, magazine, book, and a wet towel. Also, technically, an SUV.
Elodie Yung's character in District 13: Ultimatum used knives tied to her long braided ponytail to dispatch enemies.
In Daredevil, anything Bullseye throws is a murder weapon (except when thrown at his Plot Armored nemesis). This includes semi-normal things like darts, steel needles, shuriken, and one of Elektra's sai. It also includes off-the-wall items like unsharpened pencils, Daredevil's cane, paperclips, and chunks of stained glass.
Frostbite. Lawn gnome is used to kill one of the main vampires.
Jack Wilder of Now You See Me goes up against two armed FBI agents using playing cards, a wet rag, a garbage disposal, a belt stolen off one of his opponents, flash paper, and set of curtains. And comes out on top.
Tallahassee from Zombieland is a big fan of this trope. On his weapons list are garden hedge clippers, a banjo, and, at the climax, rollarcoasters.
George in Sharknado uses a barstool as a weapon on two occasions.