After Hours: Paul Hackett in this film. Going with a girl to So Ho has him losing $20, running out because he thinks the girl is severly disfigured, doesn't have enough change to return back because it's past midnight, a bar owner unable to get into his cash register to get change so they exchange keys so he can get it, seeing a robbery take place and incapable of doing anything about it, the girl he ran away from committed suicide after he goes back to apologise, two girls who like him but later abandon him when he's mistaken for a burgular by a mob, going to a punk nightclub leads to his hair is forcefully shaken into a mohawk, finding out the bar owner he met previously is the boyfriend of the girl who committed suicide after seeing him grieving, chased back into the club which is now empty and after meeting a sculptor there he is hidden in papier mache, but it hardens and she won't let him get out, as she convinces the mob he's not there, and finally, he is stolen as artwork by the original two robbers, as they put him inside their truck. It gets better as he later falls out from the back of the van, as his casing cracks and he's nearby the gate to his office, and then simply goes back to work. This is the happy ending.
The Avengers: Tony Stark. A great deal of the humor in the various action sequences involve him first being genuinely badass, but then casually getting the shit kicked out of him (once by an inanimate propeller) because he a) is incredibly smart-alecky and boastful, and getting smacked around stops him from coming off as annoying, and b) wears a suit of Powered Armor, so getting the shit kicked out of him doesn't actually hurt anything but his pride all that much.
Despite being the Big Bad Loki seems to have a few spells of being one of these, especially towards the end of the film. Every Avenger gets his goat once. Even Phil Coulson gets in a good shot.
Poor Thor. He gets beat up by Iron Man, Cap (sort of), and the Hulk.
BASEketball: Kenny "Squeak" Scholarri is scapegoated and picked on nonstop by Trey Parker and Matt Stone's characters. It is implied that this is an exaggerated look at the real-life relationship between Dian Bachar and Parker/Stone.
Ben Stiller: The man is a distinguished career Butt Monkey.
Big Bully: David Leary. Most of the crap he goes through was in his childhood, where he is picked on by the bullying Roscoe, A.K.A. Fang. However, young David eventually turns the tables on Fang by telling the school that the bully stole a moon rock that was shown on display one day, which Fang did, and got sentenced to reform school. Since then, David became a writer, as well as town hero, but he's still a Butt Monkey because people would rather buy the new Stephen King book than The Last Straw. Also, his wife divorced him and his son Ben is hardened and mean from said split, which makes him resent David and become a bully to a nerdy child named Kirby, who turns out to be Fang's son. Worst of all, Fang himself, who was thought to be changed... hadn't really changed since being sent to reform school and resumes picking on poor David, who is perceived as paranoid by the school staff.
Bill and Ted's Bogus Journey: Does this to Death of all people. He is repeatedly humiliated, first when Bill and Ted wedgie him to escape. Then he undergoes a series of embarrassing defeats at board games, is forced to appear before God in drag, suffers repeated comedic injuries on earth, and finally he can't even catch a break when he becomes part of the band that saves the world (It Makes Sense in Context). His solo albums fail spectacularly.
Bruce is a token example of this trope, and while it's not a strong showing, the movie gets bonus points for having a Literal Butt Monkey: i.e. a monkey that emerged Bruce summoned from the anus of a man who was harassing him:
Bruce: Okay little anal-dwelling butt monkey, its time for you to go home!
Not a speaking role, and not human, but apparently the "little anal-dwelling butt monkey" has a life something like this. Or at least has Word Of God going for categorizing it so.
Clerks II: Elias, Randall and Dante's nerdy co-worker, is frequently teased and picked on by Randall for his devout Christian beliefs, his fandom of Lord of the Rings and Transformers, and his lack of sexual experience. Although he loosens up quite a bit after he watches a homosexual donkey show under the influence of pot and alcohol.
Clue: Mr. Green spends the entire movie being verbally and occasionally physically abused by the other characters and/or falling victim to his own klutziness. He gets his payoff in the third ending, when it's revealed that he was a Deep Cover Agent for the FBI, and he gets to shoot the Big Bad and make a few pithy one-liners of his own.
Feast: In this film, the character "Beer Guy" is a hapless loser from the get-go. It only goes downhill for him; a monster vomits on him, causing him to become infected with maggots and rot away slowly for the rest of the film. Nobody ever takes him seriously, and he never does anything right; the film treats him like a punching-bag.
Ghostbusters: Louis Tully. Let's see... he has a crush on Dana Barrett, a cellist who lives in the same apartment complex as him, but she initially shows no interest towards him. He is also often locked out of places, in particular, his apartment room. To add insult to injury, Gozer's minions Zuul and Vinz Clortho enter the human world via the apartment complex, so Clortho chases poor Louis down (at a party he was holding) and possesses his body. However, he redeems himself in Ghostbusters 2 by helping the Ghostbusters take down Vigo!
The Godfather: Fredo Corleone. He's considered too soft for a responsible position in the family business. On the other hand Michael, not he, is sent to college so he can get a profession. Then Michael takes over the business anyway. When Fredo tries to get his own back Michael assassinates him. That must count.
Godzilla: Rodan qualifies. He loses his mate to a volcano in his debut and he is left for dead by Godzilla and he is also losing battles against Mechagodzilla. His fans think of him as The Woobie.
The Good, the Bad and the Ugly: Tuco. He isn't successful for any more than twenty consecutive minutes in the film. Of course, he is a vengeful, opportunistic bandit.... Also, even if he didn't get the gold, he was one of only 2 characters in the entire movie who didn't die. Well, in fact he got half of the gold ("Four for me, and four for you.")
Stu is the designated Butt Monkey of these films. In the first movie, he is henpecked by his horrid and unfaithful bitch of a girlfriend, loses a tooth, and accidentally marries a Hooker with a Heart of Gold while under the influence of date rape drugs.
The sequel takes it Up to Eleven, in which his soon to be father-in-law humiliates him in a pre-wedding speech. Then, after Man Child Alan drugs them yet again, he gets a PERMANENT Mike Tyson tattoo and nearly has his wedding ruined. Oh, and he receives anal sex from a transvestite.
Harold and Kumar Go to White Castle: Harold Lee. Not only does he get no respect at work, but Kumar often steals his stuff, and throughout the movie, Harold is the one who gets victimized by extreme sports enthusiasts, the police, tree branches, raccoons, and Neil Patrick Harris.
Poor Arthur. Especially when it comes to testing out the "kicks", somehow Arthur's always the one getting his chair knocked over, his gun dissed by Eames, and so on. His awesomeness at the end makes up for it, though.
Not to mention he gets shot twice at the beginning. Once just to cause him pain, and once BY HIS OWN TEAMMATE (admittedly to wake him up).
Iron Man 1: "Dummy", the robotic arm that Tony regularly calls useless and threatens to donate to a city college.
Iron Man 2: Poor Happy Hogan. If only he was in Die Hard rather than a superhero movie....
Iron Man 3: Has the Mark XLII armor, which, because of its many technical difficulties (such as its tendencies to delay Tony's Transformation Sequence and to get hit by things and fall apart), comes off as a strange kind of comic relief character.
Jesus Christ Vampire Hunter: The unnamed assistant of the Mexican professional wrestler El Santo, whom Jesus calls in halfway through the film to help him defeat the vampires preying on the local lesbian population, serves as one of these, having no lines and being observed piled with luggage that weighs more than she does, rolled over and flattened into the mud under her boss's (substantial) weight, and otherwise subjected to various humiliating and unpleasant mishaps for no apparent reason. A somewhat literal example, as the most common mishap to befall her is having her ample and shapely posterior randomly fondled by any of the other members of the cast, which she accepts with a sigh of quiet annoyance.
Lethal Weapon: Leo Getz (Joe Pesci) in these movies. Granted, he's a bit annoying but his heart's in the right place and he is actually useful. Despite this, he's treated horribly. At one point Riggs alters his medical chart in hospital so that he has to undergo unnecessary RECTAL surgery.
Little Shop of Horrors: The chubby nurse during the "Dentist" song, first Orin Scrivello casually punches her when he talks about how he loves to cause things pain, then later he knocks her out when he slams a door in her face.
The Lone Ranger: The Lone Ranger himself throughout a massive portion of the film, until he finally becomes the Bad Ass we know and love.
Mean Girls: Regina George. Half the plot and humor of the movie is about trying to mess up her life, for goodness sakes. Cady gives Regina foot cream disguised as face-wash, gives her high-calorie weight-gain chocolate bars, claiming that they'll help her lose weight, reveals to Regina's boyfriend that she's cheating on him, then proceeds to come on to said ex-boyfriend, and secretly turns her Girl Posse against her. Oh, and Regina also gets hit by a bus and survives. And of course, this is all Played for Laughs. Since Regina is a total Jerkass, however, she probably deserves it. Oh, and one more thing. A particularly humorous line is made at the expense of Regina's near-death experience. Yeah:
Cady: (after Regina gets hit by a bus) And that's how Regina George died. *Chuckle* No, I'm totally kidding!
Office Space: Milton, who gets fired but not told about it, has his pay suspended without his knowledge while they allow him to keep on working for free, gets bullied by his supervisor into working every weekend, has his favorite red stapler stolen, and is never allowed to have any cake at office parties. He does get even however when he makes good on his threat to set the office on fire and burns the building down, making off to an exotic beach club with the proceeds of Peter and Michael's ill-formed scheme. And they even get his stapler back for him. Aww.
Kershaw spends most of his screentime in Pain and Gain being tortured or made fun of. Also the Sun Gym manager that is coerced into participating the scheme by Daniel.
RoboCop: Lewis varies in degrees. She gets a few pretty good moments beating up street level mooks, but generally she seems to exist to show how awesome Robocop is. In the second movie she nearly gets strangled to death by a twelve year old. And let's not forget the third movie when Lewis refuses to take her body armor.
Rookie of the Year: Goofball coach Phil Brickman. Poor Brickman having to get himself locked between two hotel doors connecting both rooms and inside a storage cage locker during the final game.
Serenity: Several scenes were actually cut to avert this. While Mal generally has a lot of these anyways, the producers of the film felt that Whedon was taking things too far (which, arguably, he was), and asked him to remove some of the scenes to make his hero more of, well, a hero. This also serves as one of the few (or perhaps only) instances where a Joss Whedon project actually benefited from Executive Meddling.
Sid Melton: Famously from The Danny Kaye Show and a lot of B-movies. There's a reason his Fan Nickname (inspired by MST 3 K) is "Little Monkey Boy".
Singin' in the Rain: The diction coach serves no other function other than being the victim of Don and Cosmo's tap-dancing stunts in the number "Moses Supposes".
Bernard gets kidnapped by the witch Lamia, turned into a goat, put into a girl's body, almost trapped in a burning inn, kidnapped and kicked around by Septimus, before finally making an appearance at the end sequence looking surprisingly happy for all he's been through.
Probably because everybody who did those things to him had died horribly and the people who were nice to him just became King and Queen. I'd be happy, too.
Also, he dies in the book, so he's probably thankful for living at all.
According to the DVD commentary he was found by Captain Shakespeare and joined his crew.
Star Trek: Captain James T. Kirk of the USS Enterprise. Many of the film's action sequences, and much of its humor, involve him getting owned in one way or another. He also gets stranded on planets and has freaky and potentially embarrassing reactions to vaccines.
He gets choked by Spock at one point and by a Romulan at another. Both times with some pretty good acting by Pine. It hurts as you try to catch your breath afterwards. Pine actually mentioned in an interview that he admires Harrison Ford for his ability to take a beating like it really hurts, and that he considered that an underrated skill.
Kirk getting repeatedly owned in hand-to-hand combat with Spock and the Romulans is somewhat justifiable, considering they're meant to be three times stronger than humans.
C3PO. He gets little camera time in episode 1 and the camera time he does get, he's not covered, and starts off missing an eye. In episode 2 he falls down a shaft and switches bodies with a droid. in episode 3, he is gets his mind wiped. in Episode 4, he is captured, and he is trapped under several wires. in episode 5, he is blasted into several pieces. He is given a break in episode 6 when the ewoks treat him like a god.
Poor R2D2, he is always blasted, and C3PO blames him for everything. But this is mostly a result of what happens to C3PO.
Nah, he just gets too many 'save everybody' moments (in Episode 1 he saves the queen's starship, in 3 he redirects the elevator, in 4 he stops the trash compactor and in 5 he re-activates the Falcon's hyperdrive), as well as any number of other moments when he only makes badass.
Undercover Blues: Muerte (Stanley Tucci) is established as a borderline Ax-Crazy after his first encounter with Jeff Blue (Randy Quaid) but by the end of the film, most people I know are feeling a little bit sorry for him because of the sheer amount of hell the Blues put him through.
What About Bob?: Psychiatrist Dr. Leo Marvin (Richard Dreyfuss), whose life as he knows it is ruined when one of his patients (Bill Murray) follows him on his vacation. It could be argued that Dr. Marvin brings his misfortune on himself, as he is revealed through the course of the movie to be a closet Jerkass. As much of a Jerkass as Leo arguably is, many of the bad things that happen to him are the result not of Laser-Guided Karma but of Bob being a total pest and occasional idiot. Ironically, Bob actually likes Dr. Marvin for helping to cure him of his anxieties, and his attempts to be friends with the doctor and his family inadvertently cause all the trouble for Leo.
Wild Child: In this 2008 film, whenever the plot calls for (or even when it doesn't call for) a student of Abbey Mount to make a fool of herself, get hopelessly drunk and pass out in a puddle of vomit, someone other than Poppy to be bullied or even for someone to be in a life-threatening situation, it WILL be Drippy.