Tear Jerker: It's not just the animals. It's hard not to feel for the Hindus who were deceived into selling their beloved cows away to what they thought was a happy life. Little did they know the cows would have to endure hell on earth just so people can wear their skin.
Natsuki's uncle apologizing to her for how the adults treated her and Yuu in the past.
When Tomoya announces his intent to return to the Factory and divorce Natsuki, reasoning that if he does this, his family will leave her alone, and she'll be free to keep living as an alien. He may be forced to become an earthling, but if Natsuki can be free, it'll be worth it. It's remarkably effective as a Heroic Sacrifice. Natsuki is so moved by this that she hugs her husband for the first time (after previously never having more physical contact with him than a handshake with him), and persuades him to escape the Factory with her. She then says she's glad she came to Earth and married him, showing that, even if it's a Marriage of Convenience between two bizarre and insane individuals, there's still love there.
Natsuki's rape by her teacher is every bit as disgusting and horrible as you'd expect, made worse by how little Natsuki understands what's happening.
The... detailed description of the trio cannibalizing two people, and later eating bits of each other. At one point Natsuki chews on her husband's eyelids. Aaack! Then there's the fact that "earthing soup" is the first thing Natsuki is actually able to taste in over two decades.
