- Inspiration for the Work: Sam Levinson based the film's premise on a real-life incident where he forgot to thank his wife at the premiere of his film Assassination Nation.
- Serendipity Writes the Plot: The film was produced entirely during the COVID-19 Pandemic. It was written around the constraints that it had to take place in a single location and have a Minimalist Cast.
- What Could Have Been: Levinson's original pitch to Zendaya for a film collaboration was for a meta Psychological Horror movie in which she plays a Disney Channel star who goes mad, thinking she's actually her character on a K.C. Undercover-esque show. Zendaya wasn't a fan of the idea, so Levinson retooled it into what became Malcolm & Marie, which did get her approval.
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