- Creator Killer: This was Radical Entertainment's last game in the series, and poor sales combined with Activision buying the studio led to employees being laid off and/or fired.
- Franchise Killer: The game's low sales and generally negative fan reception resulted in Activision cancelling any future Crash Bandicoot games. It wasn't until 8 years later that the Skylanders series, remakes of his first three games and, to a lesser degree, the Easter Egg in Uncharted 4: A Thief's End helped Crash bounce back.
- It's worth noting that this trope didn't apply immediately: Radical planned at least one more game, which was a hard Continuity Reboot to contrast the Soft Reboot started by Crash of the Titans, with a kart racer by High Impact Games to be set in the same continuity, but Activision bought out Radical in 2010 and laid off the employees working on the first one. The kart racer was later released as Dreamworks Superstar Kartz rather than cancelled outright.
- Some would say the game on its own wasn't what killed the franchise, and it was more the end result of the series being handed off to multiple developers being handed the reigns at different points. It's hard to say if that really put the franchise into hibernation, but it certainly didn't help.
- No Export for You: Like Titans, none of the versions entered Japan. As a bonus, the DS version was made in Japan.
- The Other Darrin: Not counting his appearance in Crash Twinsanity (where he was The Voiceless), this is the first game to have N. Brio voiced by someone other than Brendan O'Brien, having been voiced by Maurice LaMarche instead.
- What Could Have Been: Ripper Roo might have been planned to appear in the game, as he is mentioned in the coding.
- Working Title: Crash: Invasion of the Bandicoot Snatchers, changed due to problems translating while keeping the joke.
Trivia / Crash: Mind Over Mutant