These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Arc Fatigue: As of writing, chapter 4 is almost 150 pages long. The second-longest chapter, chapter 1, was only about half that length, and chapter 3 was only about a third. Some people just want this arc to end so that more interesting things can be moved on to.
Growing the Beard: Chapter 1 itself started off pretty entertaining but things didn't really pick up until Chapter 2 wherein Max faces off against the Racist Whale Frog. World-building and plot thickened in Chapter 4.
Isaac, you're too anime. Explanation An inside joke with fans and in the comic itself, thanks to Isaac flaunting several tropes common to Shōnen anime protagonists such as his spiky hair, tendency to sparkle, brooding anti-hero antics completed by having what is implied to be a Dark and Troubled Past. All revealed in Chapter 3. The phrase is a reference to this installment of Gunshow.
Calling Mr. Spender variations of his name such as Mr. Splendiferous, Mr. Spencer, etc. Explanation This meme most likely arose due to Max mispronouncing Mr. Spender as Mr. Splendid in Chapter 1.
[X attack] becomes [Y!] Explanation From this strip, where Isabel's grandfather demonstrates his INCREDIBLE ABILITY to... turn spectral fists into dolphins. Huh.