These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Creator's Pet: Jason might be becoming this, due to his increased prominence.
Arguably, Andy, given how much she gets the favorable end of the Double Standard when compared with her husband, how rarely she is called out for her vices, and how often she gets to have the final word in debates even when she isn't necessarily right.
Notably prevented: The strip published July 22, 2012 was supposed to be showing Paige in the crosshairs of Jason's squirt gun. However, two days before it was supposed to run, a person named James Holmes wearing a gas mask entered a Colorado movie theater that was showing The Dark Knight Rises and proceeded to wildly fire his gun at the audience, killing 12 people and injuring 59 others. Bill Amend then pulled the strip and replaced it with a repeat of a 2009 strip.
Genius Bonus: If we listed them, we'd be here all day. Let's just say that Amend is a physics major and it shows.
Pretty much any comic where Jason expresses enthusiasm about the Star Wars prequel trilogy is this, thanks to Hype Backlash. In one especially hilarious instance, he starts spreading false information in the hopes of getting an opening day ticket; one of his claims is that Lucas decided to remove all the CG effects, resulting in Jar-Jar Binks becoming "Jar-Jar Binks, Jedi Master of Invisibility". Now consider the Phantom Edit...
Also, the strip where Jason and Marcus attempt to pitch an idea to Hollywood of making a sequel to Titanic detailing a bigger, faster, and more safe one than before (which sinks because Paige Fox goes on it due to a lottery ticket) becomes even more funny when they actually did make a Titanic sequel in 2010, this time a Disaster-genre Film.
In one strip from June 1988, Peter calls a woman on the phone, who thinks he's someone named "Steve", causing Peter to ask who Steve is. Four months later, we meet Peter's best friend, named Steve.
Jason's idea of adding in a "Darth Jason" character to the special editions of the Star Wars original trilogy (who also becomes a Sith Lord) becomes either hilarious or not as funny when Legacy of the Force has Jacen Solo becoming a Sith Lord. Likewise, Jason becoming a Sith while Luke (who is Jason's older brother) remains a Jedi in his drafts definitely become hilarious when one takes into account Star Wars Battlefront Elite Squadron, which does have the main character (X2) becoming a Jedi and his brother (X1) becoming a Sith.
The Thanksgiving Sunday strip where an apocalyptic leadin leading to Peter having his 38th slice of Turkey and Jason musing about this beating out Independence Day becomes even more funny after 2012, which bears several similarities to the leadin regarding disasters.
At the end of the arc where Jason got addicted to The Simpsons merchandise, he was musing that Bart Simpson fad is passe (which he said just because Paige brought a Bart shirt and liked it). Pretty funny when you consider that The Simpsons has become the longest running western cartoon ever and is still going to this day, but it gets better when you consider that Homer would usurp Bart's role as the most popular character a mere year or two later.
In 2000, MAD did an article that consisted of a fake set of comics for L'Osservatore Romano, the official Vatican newspaper. One of said comics included Jason reading the Bible and saying, "God has an unseen power that's everywhere, inside everything. Satan tries to seduce Jesus over to the dark side, then Jesus comes back from the dead[…] If I'm not mistaken, George Lucas has the mother of all copyright-infringement lawsuits here." A few years later, FoxTrot ran a strip whose punch line was remarkably similar to the parody one in Mad.
This one becomes funnier given Michael Jordan would later wear a Hitler mustache in Hanes ads.
Roger's company is having financial trouble and has had to lay people off...his boss, Pembroke, asks him to put together graphs to justify his raise, when he already has millions. Amend successfully predicted the behaviours of banks, Wall Street, and corporations post 2000, and one of the reasons that led to the Occupy Wall Street movements!
Also, some of Jason's more Jerkass moments towards Paige Fox become somewhat more understandable when it was revealed that Paige often tried to scare Jason with her teddy bear.
Paige may be a jerk to her brothers but Jason goes out of his way to mock her with his Paige-o-Tron comics and taunt her with Quincy, she has no friends outside from Nicole who is more popular with boys, her older brother tricked her into waiting in the rain for a fake boyfriend by writing phony love letters, all of Paige's attempts to get a hobby are treating like jokes (cooking, auditioning for a play, writing a short story), the kid she babysits for calls her "Pag" (which is also baby-talk for "pig"), she's not good at any of her classes in school (and Jason has actively tried to make her grades WORSE by giving her wrong answers when she asked for homework help) and Morton Goldthwait, the one boy who was willing to date her is implied to have gotten over his crush.
Jumping the Shark/Seasonal Rot: How some feel about the strip's transition to Sunday-only format, though others believe it had reached this point long beforehand.