These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Harsher in Hindsight: Lance Armstrong being stripped of his winnings for blood doping (which is considered cheating) in 2012 and his subsequent confession of the fact in 2013 changes the implications of the scene he appears in.
He still did survive cancer, and he's far from the only cheater in the sport during those years. Between 1999 and 2005, every single rider in top 3 of those Tours have been heavily implicated, if not outright busted for doping. One would have to go outside top 10, sometimes even top 20, to make a clean podium.
Memetic Mutation: Lance Armstrong's cameo is now being circulated as a joke around the Internet due to the athlete recently being stripped of his titles.
"That's a bold strategy, Cotton. Let's see if it pays off for 'em/him/her." when someone does something risky or stupid, especially on Imgur. The use in-context was Cotton pointing out that Average Joe's was forfeiting the match.
Squick: Justin's flashback, White at the end of the movie, Owen and Fran in bed...
...White and the pizza slice.
Unfortunate Implications: The revelation that Kate and her partner are bisexuals goes hand in hand with them turning out to also be incredibly easy and willing to engage in a menage a trois with Peter (especially with Kate's girlfriend who just met the guy).