- Absentee Actor: Multiple episodes. One of the most memorable was in "Captain Hero's Marriage Pact," Toot and Clara (both voiced by Tara Strong) are virtually absent from the entire episode until the last few minutes. This could be due to Strong dedicating the majority of her time voicing Unusually Flexible Girl in that episode. The writers quickly Lampshade this:
Clara: Have you noticed we haven't been getting any screen time this week?
Toot: Well, uh, duh! That's because we've been in the basement all week making this awesome potato gun!
- Acting for Two: Tara Strong does the voices of both Toot and Clara.
- Actor Allusion:
- Cree Summer voices a Team Mom Third-Person Person Sassy Black Woman who wears a red cap. Sound familiar?
- One episode had a future version of Wooldoor that dressed and sounded like Marty McFly. James Arnold Taylor has served as a voice double for many celebrities (usually in edited-for-TV movies who need sound-alikes to record alternate lines used to cover up any line that's considered offensive), including Michael J. Fox (Marty's actor).
- Contest Winner Cameo: In "Spelling Applebee's" - the waiter that Captain Hero makes out with on his date with Clara.
- Cowboy BeBop at His Computer: Xandir's whole "Never ending quest to save his girlfriend until he realized he was gay and switched to a never ending quest to save his boyfriend" thing was really only important for the first three episodes of the first season. Most media outlets that described the show acted like it was an important part of his character (can also be They Wasted a Perfectly Good Character).
- Same deal with Clara's Octopussoir. It's mentioned in exactly two episodes, yet articles on the show speak of it like it's a vital part of her character.
- Cross-Dressing Voices: The male Ling-Ling is voiced by the female Abbey McBride. Also, whenever a young boy shows up, he's generally voiced by Tara Strong.
- Playing Against Type: Jess Harnell, Cree Summer, and Tara Strong are better known for their roles in more kid- and family-friendly type of cartoons such as Animaniacs, Codename: Kids Next Door, and The Powerpuff Girls. In Drawn Together, however, the characters they portray are the exact opposite of family-friendly.
- In fact, Tara Strong has stated that she loved working on the show because of how much of a departure it was from the kids shows she was used to at the time.
- Screwed by the Network: Comedy Central's broadcast schedule for the series was erratic, to say the least. When new episodes were not being screened, the show would often be off the schedule for months. Many viewers assumed the show was cancelled long before it actually was. It also had a gap of over a year between the first and second seasons. And one almost as long between the two halves of season 3.
- Short Run in Peru: The second half of Season Three, delayed by Comedy Central for almost a year, was broadcast in Latin America two weeks before the US.
- Talking to Himself: A small handful of performers, also members of the main cast, voice most of the guest roles on the series. Tara Strong even voices two ''main'' characters, Clara and Toot.
- Too Soon: "Terms of Endearment" was shelved for over a year following the death of Christopher Reeve, whose paralyzing horse riding accident was parodied in the episode.
- Bit of Fridge Logic as to why they would draw the line there of all places.
- The dude was Superman. And was then confined to a wheelchair. It wasn't right at that point. Now, though, we can laugh.