Fan Disservice: "Vince Takes a Bath." You will never un-see anything that appeared on screen in this episode. Ever.
Molly: (holding up the towel on Vince's lap while Mike walks in) Look at it! Look at it!LOOK AT IT!!!!!!
Going Commando: In one episode Joyce is wearing a Little Black Dress to go out to dinner with an ex-boyfriend of hers. Vince says that he doesn't want her coming home with her panties in her purse. Joyce tells him not to be stupid, as she never wears panties with this dress.
Hidden Depths: Most of the time, Victoria is just a goofy stoner, but in the episdoe "Victoria Can't Drive", she spouts out some very surprising insight about her views on the afterlife, and convinces Mike's mom to come to his wedding, not taking any credit for it.
Idiosyncratic Episode Naming: Not completely consistent, but the large majority of episodes begin with a character's name, followed by an action relevant to the episode. (ie "Mike _____", "Carl's _____", etc.)
Love Makes You Crazy: Molly's sister Victoria is ... unlucky in love to say the least. Molly and Joyce had to physically stop her from going after her married boyfriend.
Mistaken for Gay: Carl and Mike are mistaken for this "at least three times a week." In the season 3 premiere, Carl gets a temporary partner while Mike is on his honeymoon, and on their last day together the partner kisses Carl full on the lips, resulting in a Heroic BSOD.
My Beloved Smother: Mike's mom, who fakes a heart attack as soon as she finds out Mike is on a date with Molly.
Another episode has Mike getting very sick and being taken care of Molly at his place. His mother shows up and steals him back to her place and them stealing him back & forth. Eventually, she gets him last and alludes to possibly hiding him in his uncle's ice cabin to keep her away.
Wrong Insult Offence: In "Fish for Breakfast", Carl's latest girlfriend (who thought she was going to a party) calls Mike and Vince (Mike's mother-in-law's fiance) as "two gay guys eating a banana split". Mike protests that he hasn't had a bite of the banana split.