The Crow by James O'Barr - When his fiancee is raped and murdered by drugged-up hoodlums, Eric doesn't let the fact that they killed him too get in the way of his Roaring Rampage. Said Rampage is arguably more visceral, violent and over the top than it was in the subsequent movie adaptation, and the actual nature of Eric's literal physical resurrection not explained as clearly.
Screw with Batman and you'll either wind up in a hospital for the rest of your life, crying yourself to sleep each night or want to die immediately due to recurring nightmares involving a half-man, half-bat demon or go far far into the world and pray to god that he doesn't ever find you again. More than likely, you'll be going through at least two of these after your encounter with him. There's a reason career crime in Gotham breeds mental illness.
The Murderer/Fugitive arc has Bruce framed for the murder of his old love Vesper Fairchild and is wrongly imprisoned (score another one for the GCPD). Bruce escapes from prison to fight crime as Batman (since his Bruce Wayne persona was slowly slipping away) and cuts off all communication with the rest of the Bat-family. Long story short, as soon as Batman slowly starts picking up the clues of the people who framed him. HE. MAKES. THEM. PAY. DEARLY. After his fight with the commandos nearly everyone who he fought will need to see a psychiatrist. Or a priest.
Scarecrow has had a few of these, notably the incidents with his prom and grandmother.
Nightwing, after seeing his apartment building (with his neighbors inside) blown up and his circus destroyed by Blockbuster, hunted down and brutally beat down every one of his costumed mooks.
Nightwing is prone to this. During KnightsEnd, he tore into Jean-Paul Valley after thinking Bruce was killed by a booby-trapped Batmobile and during Joker: The Last Laugh, he actually killed the titular villain when he thought Tim Drake had died.
X-Men spinoff X-Factor shows even an enemy's simulator knows that if you hurt/kill Rictor, Shatterstar's Roaring Rampage Of Revenge would come next, quickly followed by your demise.
Marv of Sin City goes on one of these when his lady of the night Goldie is murdered and he is framed for the crime.
And in Sin City: Family Values, Dwight and Miho cut a swath through the Sin City Mafia to avenge the shooting of a prostitute.
Wallace of Hell and Back also goes on one of these when Esther, the woman he saves from suicide, is kidnapped.
In all adaptations of The Punisher, the entire plot revolves around this, to the point where it's less a Roaring Rampage of Revenge and more of a Roaring Marathon of Revenge. In the comic, Frank Castle's family was killed when they stumbled upon a mob execution while having a picnic in a park. In revenge, Frank kills the people responsible and then goes on to kill all the other criminals he can find. In the movie, Frank was once in the FBI, and his family was specifically targeted.
It may be worth noting that when that entry says "his family was specifically targeted", it means his entire family. The Big Bad's hit men attacked a Castle family reunion.
The ultimate example comes in the form of Punisher Kills the Marvel Universe, which is Exactly What It Says on the Tin. Whether this represents a parody or a crowning homage to the character is open to debate.
The Incredible Hulk goes on one of these in the Cross OverWorld War Hulk. Why? The six most influential people in the Marvel Universe sent him into exile on an uninhabited, peaceful planet — except that he landed on a savage planet that put him through immense hardships before he earned his happy ending. Then the ship he arrived in exploded, nuked the planet, and killed the Hulk's alien wife. Cue rampage.
Shortly before that story, Marvel had retconned several of its main heroes into such utter douchebags that even though the Hulk was technically the villain of the story, most readers were rooting for him to smash the Illuminati. And even though it was revealed that the main crime — the explosion of the ship — was not their fault, Doctor Strange openly admitted that they had been wrong to exile the Hulk and that they probably deserved what they had coming.
The What If?: Planet Hulk special included a What If? of that story where the Hulk died in the explosion instead of his wife, and she came to Earth on a roaring rampage of revenge instead. The end result was much, much worse.
Besides The Punisher, Marvel's other resident avenger Wolverine has been featured in some high-spotlight revenge arcs. Kinda hard to avoid when you're a killing machine with a hair-trigger temper.
The Marvel event Civil War kicked off because a lone villain named Nitro blew up a small town in Connecticut. While all the heroes were slap-fighting each other over federal legislation, guess who it was that hunted down and tried to destroy Nitro for his mass murder?
And don't forget about Matsu'o, who commissioned the murder of Logan's lover Mariko. Every year on the anniversary of Mariko's death Logan cuts off a little bit more of Matsu'o; he's currently missing his right arm, right ear, nose, and gall bladder. If it weren't for Comic Book Time he'd probably be a head in a jar before his death. Wolverine said his punishment wasn't over but finally relented and let Psylocke finish him off.
Then there's Mark Millar's "Enemy of the State" and "Agent of SHIELD" arcs where Hydra, TheHand, AIM, and upstart group Dawn Of The White Light lure Logan in by kidnapping and killing an innocent child. Then they brainwash him and send him after the super-hero community like the weapon he once was. When he gets his mind back, he reprograms a Sentinel to kill the hundreds of members of the Dawn of the White Light mutant group, then kills thousands of Hand members, then kills 40,000+ Hydra agents, then slices up the dozens of thugs who were tangentially related to just the kidnapping aspect.
And then there's his horror movie style hunting down of a bunch of guys who broke the spirit of a nun to the point where she begged Wolverine to make them suffer, which he did on the five year anniversary of her death (they didn't kill or even harm the nun, just broke her spirit with fake execution after fake execution, and Logan was avenging the loss of her innocence). And his slaughter of the pirates/slavers who hijacked a plane carrying one of Mariko's personal secretary was in part to avenge those that they'd murdered or worse over the years. And the slapstick one he did on the Madripoor underworld using Mr. Fixit as a proxy.
Near the end of the comic book series 52, Black Adam's wife and brother-in-law are killed. As it was the death of his first wife that caused his original fall from grace, it is unsurprising that the death of the second led to him going on a Roaring Rampage of Revenge, wiping out the country that harbored the murderers, and anybody else that stood in his way. It doesn't end well, though, as the nerdy Mad Scientists behind her death soundly kick his ass with SCIENCE.
And when he escapes from that, he just declares bloody vengeance on the entire world, leading to the week long World War III.
Abslom Daak, from the Doctor Who Magazine comics. Because they killed his lover (whose corpse, now cryogenically frozen, makes her into a literal woman in a refrigerator) he's gonna kill every last stinking Dalek in the galaxy. Implicitly, a bit of a lunkhead, which got made explicit when he got to meet the Doctor, who took the mickey out of him.
But ultimately (and posthumously) he was honored for a Heroic Sacrifice with a new moniker: "Abslom Daak, Life-Giver".
Swamp Thing returns to earth after a forced exile. Step one is to kill the people responsible for his unexpected interstellar journey.
The titular V has the titular vendetta in V for Vendetta, coldly eliminating everyone who worked at the camp where he was imprisoned, then moving on to overthrowing the government and killing everyone who was responsible for the very existence of said camp in the first place. Just before his work is done, he dies, and leaves the very last step and the cleaning up afterwards to Evey.
Subverted in Fables. Flycatcher wants to go on one of these after remembering what the Empire's soldiers did to his family, but Boy Blue refuses to teach him the secrets of the Witching Cloak that would let him do this, because he doesn't want to corrupt the only truly innocent Fable left. Ironically, this leads to him taking out the Empire's most powerful magic source, and causing far more damage to the Empire's armies than he ever could have on a RROR without ever killing a single soul.
After the apparent death of Batman in Final Crisis, Superman returns to Bludhaven with a Roaring Rampage of Heat Vision, taking down as many of Darkseid's troops as he can see.
Ultimate Marvel recently re-introduced the Ghost Rider, distilling his origin as he and his lover Roxanne were innocents killed as human sacrifices, so the perpetrators could bargain for power from Mephisto. As it turns out, Ultimate Johnny Blaze sold his soul to Mephisto, too. All so Roxanne could be spared the suffering, and Johnny could hunt and kill the monsters that did this to them. Just one problem: One of the sacrificers is now the U.S. vice-president.
Johnny in Strontium Dog goes on a massive one across several planets after Max Bubba kills Wulf.
In Ms. Tree, Michael practically makes a career of this. Any time there is an attack on her, her family or her friends, this is almost guaranteed to be a huge stack of enemy corpses at the end of it. It got to the stage where The Mafia didn't want to mess with her because it was too costly for them.
Most of the Red Lantern Corps are on one in one form or another, given that their superpowers are fueled by rage driven by loss, and as such that rage tends to fixate on the ones responsible for that loss. It's also such an overpowering rage that they tend to take down anyone and anything that gets in their way as well. Special mention must go to the Red Lantern of Earth, Dex-Starr. He's a housecat, and is trying to avenge the kindly old lady who owned him.
While there are many of these in the series an obvious example takes place within IDW's Transformers run, during Cliffjumper's Spotlight comic. Crashing on a world he manages to create a strong bond between himself and one of the locals called Kita. A few days after his arrival Decepticons arrive and manage to injure Cliffjumper and shoot Kira in the back when she attempts to run. The Decepticons call for backup in hunting him down leading to this brief exchange upon figuring out just who it is they've managed to piss off:
In the Disney series Paperinik New Adventures, this is what drives the character of Xadhoom. Having seen her entire planet destroyed and her people reduced to mindless slaves, she swore revenge on the alien race that caused it, the Evronians. Unfortunately for the Evronians, Xadhoom had recently become one of the most destructive forces in the Universe, having the destructive power of a super nova. Xadhoom now hunts the Evronians all over the Universe, killing as many of them as she can. (And that's a lot.)
To better illustrate, here's her last act. After she destroyed the Evronian mobile throneworld (think a starship the size of a small moon) and before becoming a sun to help the last survivors of her people, she prepared an artifact that contained a copy of her memory and mind. An attempt to leave a memory of her and a copy of her immense knowledge (like how to become like her. She actually told her people they should have become like her, as she was basically immortal and undefeatable, before becoming a sun), you think. It later turns out she had also sent her father out to lure at least a last Evronian into stealing it to acquire the secret of her power, so she could tell him how... And enjoy how he would get destroyed by that power and the lack of the needed self-control: the readers already knew she had a self-control bigger than even herself thought possible (as shown that one time she was so furious everybody including her expected her to go nova but she ONLY destroyed four roofs of a skyscraper, and when the Evronians finally captured her and tried to torture her into becoming an eternal energy source but she resisted pretty easily), but given how impulsive and furiously she acts you would never expect it. And yes, she disintegrated a last Evronian in the most humiliating possible fashion after having practically died, and set things up to continue as long as the surviving Evronians will fall for it.
Spider-Man has one in the first "Sin-Eater" story arc. The Sin-Eater is murdering people left and right, and one of his victims is Captain Jean DeWolfe. As she was one of Spider-Man's friends and supporters, he takes her death very hard and this adventure very personally. Ultimately, Spider-Man finds the Sin-Eater (who has no superpowers, by the way) and brutally beats him to a pulp. If not for Daredevil, Spider-Man seemed quite likely to kill him.
A somewhat similar incident occurs in the Ultimate series. A punk dressed up as Spider-Man had been robbing banks and destroying the little amount of good reputation that Peter had built up when taking down Doc Ock for the first time. While robbing an armored truck, the imposter is confronted by Police Captain Stacey, father of Peter's friend Gwen, and a bullet ignites the plastic explosives in the criminal's backpack. He quickly shrugs it off and throws it away, and it arcs right towards a nearby child. Stacey, in keeping with the death of the character in the original universe, throws the child out of harm's way and is killed when the explosives detonate. Later on, Peter hears a report that the imposter is attempting to rob another place and finally confronts his double face to face. After a brutal beat-down, Peter locks his hands around the man's throat and very nearly strangles him to death while screaming his fury into his face.
In the Grim Hunt storyline, the Kravinov family had been messing with Spidey for weeks and eventually killed several of his superpowered friends. Spider-Man goes berserk, taking out the whole clan and even used his wall-crawling grip to tear off a chunk of Sasha Kravinov's face.
And of course, there was right after the events of Civil War when Aunt May was shot by an assassin sent by the Kingpin after he exposed his identity to the world. Donning his black costume to let everyone know he meant business, he tore across New York until finally locating and delivering a huge beatdown on the Kingpin, threatening to finish the job if he couldn't find a way to save Aunt May (we all know how that turned out). In a What If?, the assassin shoots (and kills) Mary Jane instead, causing Peter to snap and actually kill the Kingpin.
Used as an Invoked Trope in the recent Thor and Journey into Mystery comics. The only reason no one has killed the reincarnated-as-a-kid Loki yet for his past deeds is because Thor has sworn to do exactly this trope if anyone hurts Loki and he finds out about it. Or if Loki just suddenly dies, even if there's no proof, because Thor's not an idiot.
This is the plot of the first story arc of Jennifer Blood: the eponymous anti-heroine is out to wipe out the organized crime family that murdered her father and drove her mother to suicide. Of course, her father had been the head of that family, and the men who killed him were all her uncles. The subsequent story arc seems to be shaping up to be that the relatives of three assassins who had been hired by her uncles and whom Jennifer had killed along the way are now determined to track down the person who killed their loved ones and kill her and all her loved ones....