Just so you know: Ragou extorted an entire town into starvation via heavy taxes, and when the civilians couldn't pay up, he had their children kidnapped and fed to monsters. He also fired on his own ships for daring to try and bring food to the townsfolk. Cumore tricked dozens of peasants into working in brutal slave camps and later sent an incredible number of villagers into the desert on what is basically a suicide mission looking for a Physical God. Alexei is the worst of them, though. He kills innocent Entelexeia to obtain the crystals they leave behind on their death, and at one point callously mocks the small size of one of the jewels left behind. He uses these crystals to force Estelle into becoming Brainwashed and Crazy so that he can use her powers (which not only hurts her, but also threatens the entire world if used too often). He revived Schwann and Yeager from death using heart blastia and forced them to become his slaves and even tried to destroy the Hub City of The Empirethat he led—an act which would kill tens if not hundreds of thousands—as a distraction. Do you hate this guy yet?
Kvar is noted in-game as having a reputation as "the cruelest of the Desian Grand Cardinals, and that is really saying something. He's basically a Josef Mengele Expy who tells Lloyd that he experimented on Lloyd's mother until she became a mindless monster, and in order to protect Lloyd from her, Lloyd's father had to kill her himself. Talk about It's Personal.
Vharley is a stooge of Rodyle and a bastard in his own right. An Exsphere broker, what was his response when Regal denied him access to his Exsphere mine? He tortured and experimented on Regal's lover until she could do nothing but beg for death...and ensured that Regal would have to kill her with his own hands.
Tohma from Tales Of Rebirth also counts. A sadistic Gajuma/beastman with extreme hate for the other races for no good reason other than 'racist superiority thought' may not be calling it, but the main kicker is how he sadistically and gleefully manipulated the life of Hilda Rhambling. The amount of him kicking her is really depraved.
There's also Saleh, who is an utter sadist who enjoys torturing people simply so he can watch them writhe in pain. He never gets any sort of Freudian Excuse and seems to be roaming the world kicking puppies as much as possible simply because he enjoys it. However, unlike Tohma, Saleh is fairly pretty...
Both of them works for Zilva Madigan, who turns out to be just about as bad as Tohma, and she pretty much manipulated the whole Kingdom of Callegea in order to ensure that Gajuma reigns supreme and all Huma are eradicated. No, it's not because of the Fantastic Racism that she suffered, but because she just thinks that she and the Gajuma are superior, and thus deserving to rule (basically a female Tohma). She manipulated the kidnapping of Huma girls to be switched with Agarte just so the latter can be with Milhaust, and thereby kickstarting the game's events, and later on, she possessed the body of Dr. Barrs to strike at Eugene, thereby framing him for exile and not only prevents him from advising Agarte further, but also set Barrs' daughter Annie into a path of vengeance and turn her into a Gajuma-hater. When both work out and eventually confront and defeat Zilva, Annie nearly killed her only to back down just so she doesn't become as bad as her. Zilva's response wasn't even gratitude, but openly declaring on how much family love disgusts her. Even Hilda had to admit that most of Tohma's atrocities rooted from Zilva.
Tales Of Destiny seemingly was devoid of unsympathetic villains (Hugo was, in fact, mind controlled and loved his children very much, Miktran/Kronos believed that the Aetherians are right, making him in line with Dhaos, until the remake retooled him into a Card-Carrying Villain) until 2 introduced Barbatos Goetia, a man so evil that, after his defeat by Dymlos, his name is removed from history altogether. After Elraine resurrected him, Barbatos happily became her Dragon in order to mark his name in history (and be praised as a hero instead, as seen in an alternate timeline) and has no qualms about murders, be it for missions or for the heck of it. The first time we see him on-screen during the flashback, he crosses Moral Event Horizon big time by holding Loni hostage and forcing Stahn and Rutee to drop their weapons, and then proceeded to outright murder Stahn and crippled Rutee, all in front of young Kyle's eyes. In the present, he also tried to kill other heroes like Philia and Garr/Woodrow just to eventually get himself marked in history. Looks fine, but when his method involves such brutality for the heck of it, he can't be a Well-Intentioned Extremist, but a Complete Monster who thinks It's All About Him. Though he's hilarious enough (with an epic voice to match) to double as an Ensemble Darkhorse.