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- Robotnik runs one of these in the earlier Archie Comics' Sonic the Hedgehog.
- The evil boss of the logging company in the Don Rosa Scrooge McDuck story "War of the Wendigo" goes really over the top with this when the Pygmy Indians and their natural allies storm the building to stop him cutting down all the trees. He orders his workers to pump out lethal gasses to kill the bats nestled in the exhaust pipes, dumps acid in the drainage to boil the frogs clogging up the sewer, and when his employees decide Screw This, I'm Outta Here! he goes completely Ax-Crazy with a flamethrower to burn the whole forest down.
- The 1990 action-comedy film Men at Work is heavily related to this trope, as the two protagonists are facing a company illegally dumping toxic matters.
- In The Karate Kid Part III, Corrupt Corporate Executive Terry is president of... Dyna-Tox Industries.
- It is revealed in Teenage Mutant Ninja Turtles II: The Secret of the Ooze that TGRI is the corporation that produced the mutagen that mutated the Ninja Turtles, and in the story are trying to clean up the contaminants that the company dumped onto the land, which mutated the surrounding plant life.
- Mr. Grosso's business in House IV involves a lot of toxic waste. So much so that the plot is driven by his flunkies trying to claim the main setting to dump it there.
- The Lorax and its animated adaptations: The Once-Ler pretty much destroys the whole environment through his Thneed factories. It is of course even more precise in the animated adaptations, as much of the effects are shown on-screen. It's worth noting that, unlike many examples, the Once-ler is an Anti-Villain who comes to genuinely regret the things he's done.
- In several issues of Butler Parker, he confronts waste dumpers - most of the time companies that are supposed to dump toxic waste safely that decided they'd earn more money easier by dumping the waste into regular wast dumps. The managers of these companies often end up swimming in the waste or adrift on a float on the waste, waiting for the police to pick them up.
- In Sahara by Clive Cussler, Dirk Pitt discovers a solar waste incinerating business in Mali is a sham—they're dumping the highly toxic waste into an underground river which further on empties into the Niger. The waste not only causes the sea flora to grow uncontrollably, endangering the sea ecosystem, but also causes people drinking from the contaminated water to become crazy, cannibalistic beasts. In the end Dirk Pitt first stakes out the owner of the facility in the desert heat, ostensibly to force him to confess. When Massard, the culprit, doesn't, though, he finally releases him and gives him a drink of cold, fresh water—water he picked up from a poisoned well a bit along the underground river. Afterwards, Pitt confesses to his associate that he did the whole staking bit only so Massard wouldn't question the water and wouldn't notice the metallic taste.
- In the MacGyver (1985) episode "The Spoilers", Mac and and a hermit from the mountains work to try and stop a group from illegally dumping radioactive and toxic waste into a stream.
- Global Chemicals from the Doctor Who story "The Green Death", whose casual discharge of toxic waste into an abandoned mine leads to a plague of giant mutant maggots. This is actually the less serious element of what's wrong, as the company turns out to be run by a mad gay computer that wants to Take Over the World.
- In Dilbert, there was a strip in which the Pointy-Haired Boss showed concern that kids were spending too much time outside to care about their company's product. Dilbert suggested that the company diversify their product base, but the PHB decided that he'd just pollute.
- Many Pentex subsidiaries in Werewolf: The Apocalypse. The small fries think they are just doing it to cut the cost. The leaders know they are doing it entirely on purpose, because the whole company is under control of an Eldritch Abomination seeking to corrode both the physical and metaphysical bonds of creation so that it'll be freed from its prison.
- The ClueFinders 6th Grade lists several generic companies and cross-references them with a list of pollutants. The objective is that the player is supposed to identify which companies are putting out which toxins by knowing which industries use a particular toxin and whether the company is reported as innocent or not. Once that's finished, the Cluefinders intervene and convince them to stop.
- Four of the later stages in Crash Bandicoot (1996) take place within Cortex Power, a nuclear power plant built by Neo Cortex and managed by Pinstripe Potoroo and his gang. The power plant in question is unsafe and dirty, and is responsible for polluting the nearby bay with radioactive waste. Cortex Power is shut down during the events of the game (Pinstripe Potoroo accidentally shoots out the main reactor when he is defeated), but this seems to cause a blackout in the later stages set inside Cortex's Castle.
- Never mind the demons from Hell, the UAC from Doom cannot be doing anything good for the Martian enviroment with all the deadly radioactive waste they have lying around. As the DOOM Guy himself notes in the Doom comic:
"Even if I personally stop this alien invasion, what kind of planet will we be leaving to our children?"
- Astex Mining Corporation in Escape Velocity, a Mega Corp. allied with the Confederation whose sole purpose in the plot is dumping toxic waste into the oceans of planet Diphidia II.
- Half-Life: Black Mesa's extreme lack of concern for safety extends to the environment as well. They have so much glowing green toxic sludge that it can form a waterfall.
- Oiligarchy has you under the control of a massive oil company. Your business causes the likes of animal life dying off.
- Donkey Kong Country
- Kremkroc Industries, Inc. from Donkey Kong Country, which has ruined a portion of Donkey Kong Island, though the Kremlings (whose own island is a polluted wasteland) probably don't care about that.
- Several areas in Donkey Kong Country 3: Dixie Kong's Double Trouble! (especially the heavily industrialized Mekanos) have also been contaminated by the villainous reptiles, with the main toxins being able to cause Interface Screw.
- In Ratchet & Clank (2002), it's eventually revealed that Chairman Drek deliberately polluted the Blarg homeworld to the point of rendering it almost uninhabitable, so that the Blarg would be forced to buy a brand-new, custom-made planet from him at a premium rate.
- Banjo-Tooie has Grunty Industries, whose chief products are apparently Deadly Gas and toxic waste.
- In Kirby: Planet Robobot, the Haltmann Works Company invades Pop Star and quickly send their machines around the planet to gather resources. One of the many stage hazards they cause is Deadly Gas which is blown around by fans. This game also introduces the mid-boss Misamoros and an unnamed new enemy, which are toxic goo monsters that give the Poison Copy Ability.
- Team Kirby Clash Deluxe has the Mad Scientist Flask as purchasable equipment for the Doctor Healmore role, filled with some purple liquid and labelled with an ominous black skull. The Flavor Text states that it's rumored to have been created by a "notorious technology company," likely referring to the Haltmann Works Company.
- Avatar: The Last Airbender had an episode about the Fire Nation's machine factory causing pollution that mutated the fish in the river.
- In Ben's City, Minister of Environment Henry Wallet and his counselor Ben face twice the owner of an enterprise named Toxicompany, which heavily pollutes the air. Only in its second appearance do we learn they are manufacturing paint thinner. Aggravating factor for sure.
- Captain Planet and the Planeteers is pretty much built around this trope. The show is already a heavy Green Aesop series and most villains are polluters. In all these villains, there's got to be quite a few that are companies bent on polluting. Probably an Enforced Trope, as a more realistic characterization would cause young viewers to think poorly of real adults working in similar industries.
- The Cramp Twins has Hazchem, Soap City's premier manufacture of heavy-duty cleaning products and despoiler of the local swampland.
- Family Guy
- Santa's workshop in the episode "Road to the North Pole". Its chimneys are spreading pollution in the air, and large pipes spill even more pollution in the North Pole. Oh, and considering this part of the world is already directly affected by all the pollution, it only makes things worse...
- In the episode titled "It Takes a Village Idiot, And I Married One", Lois discovers that Lake Quahog is severely polluted and that a local oil refinery is responsible, and since Mayor Adam West authorized their dumping toxins into the lake, she runs for mayor against him. When she wins, she has the lake cleaned up and prohibits further dumping, but embezzles the leftover cleanup funds, and is soon blackmailed by the company executive into allowing them to dump toxins in the lake again. There's even a ribbon-cutting ceremony re-opening the pipe dumping the toxins.
- Not necessarily a company, but in Futurama, one of Professor Farnsworth's inventions serves a nearly-useless purpose yet creates tons and tons of toxic waste.
- In The Oblongs, Poison company Globocide. Aside from their products, the company is impliednote to be responsible for the squalid conditions and deformities of the people living down in the valley.
- Cyril Sneer's company in The Raccoons disregards entirely for the environment and is up to the Raccoons and friends to foil most of his Get Richer Schemes that would damage the environment.
- Scooby-Doo! Mystery Incorporated. Destroido is responsible for a lot of pollution; it turns avocados into monsters.
- The Simpsons:
- In "The Old Man and the Lisa", Mr. Burns discovers thanks to Lisa the joys of recycling, and to thank her, he builds a factory that bears her name. However, Little Lisa's Patented Animal Slurry uses millions of six-pack plastic holders stuck together to clean up the seafloor, grabbing plants and animals, and turning them to a multi-purpose compound. He destroyed the ecosystem of the seas surrounding Springfield. Definitely an aggravating factor.
- Burns' power plant is responsible for a lot of environmental disasters surrounding Springfield, and all the jokes the staff can think up to go with the mutations caused to the fish. Remember Blinky?
- Super Friends (1973-74) episode "Dr. Pelagian's War". The title ecoterrorist uses his control of the weather and the oceans to try to convince the owners of three companies to stop polluting the environment.