The Scotsman from Samurai Jack is about three times Jack's size and tough as nails but is easily capable of matching Jack's speed and strength, fighting him to a standstill for three days and nights.
Don't forget the Minions of Set. Despite having hugely overbuilt upper bodies, very short, slender legs and enough weight to make the ground rumble beneath their feet, they are extremely fast and agile. Jack is so overwhelmed by the way they constantly jump around in combat he can hardly tell what direction their attacks are coming from.
His successor, Korra, is even more of one, which shouldn't be surprising given that she's the result of the world's most intrinsically-talented bender being raised from childhood in multiple forms of martial arts. Even without the Avatar State, she's able to overpower just about everyone, and one she starts learning airbending, she becomes just as adept at evasion as she is at tanking hits.
The same could be said for many of the villains. Amon is an extremely agile and nimble fighter with the strength to take down even the most skilled benders with no sweat, Vaatu's massive size amd damaging power definitely doesn't reflect his speed, just like other spirits and Unalaq moves extremely fast & hits very hard.
Optimus Prime in Transformers Generation One, if the tech specs are anything to go by. Compared to the rest of the Ark crew, he matches or outpaces other characters who are considered specialists - among other things, he's stronger and tougher than Brawn, just behind Bluestreak in firepower, and every bit as fast as Windcharger. When you're a truck and the only character who can outrun you is a jet fighter, you know you're lightning-fast.
Steven Universe: features Garnet, who's both superhumanly agile and a top-class bruiser. Her footwork and movement speeds are comparable to Pearl and Amethyst, and she's also the offensive heavyweight of the Crystal Gems. This makes sense as she's a fusion of Ruby and Sapphire.