"Promise me. You'll keep them safe. That's all I ever..." ... Peter Parker trapped in Dr. Octopus' broken body to Doc Ock in his body, referring to MJ and his friends.
"Yes. And to save her... I must give up every part of that love. For I know... only you can save her. Because you are The Superior Spider-Man." Doctor Otto Octavius, returning Peter Parker's memories and body to the man and erasing himself.
"Terms and conditions apply. Here, General Eccentric, is there a place for silliness in your fascist dreamworld, sir? Got anything for me?" John the Skrull, before getting a 'no' response via a shot to the face.
"It won't work, Richards! I can sense your presence inside the computer! You designed even your thinking machines with the capacity to defend themselves!" Doctor Sun
"But now, I fear, your effort to trap Dr. Sun within the master computer is only too succesful! With every circuit closed to him, he will have only one place left to run— back into me. Should that happen, he will take control of me again— and all your lives will be in danger. My programming cannot allow that." H.E.R.B.I.E., the first one
"Papa..? I... am... cold." Titanium Man.note [[spoiler:Pretty poignant considering that he was one of the worst hardasses ever, a hard-line Soviet Communist who had actually never shown any emotion except anger before. Jury's still out on whether he got better.
"I'm the smartest man in the world. You can't even touch me!" Prodigy
"I love you, David" Surge, before overloading her gloves, thereby destroying Prodigy and herself. Fortunately for all those involved, all of the previous turn out to be All Just a Telepathic Illusion
"H-hey... you're... pretty." DJ to his would-be rescuer, X-23. Notably, this is his one and only line in anything; he'd previously only appeared in crowd scenes, and was named by supplementary materials
"Josh, no." Wallflower
"I didn't know..." Icarus, this time for real
"I will not fail you, Lord. I am your serv— AAAAAAHHHHHH!" William Stryker, as Elixir gives him a well-deserved case of terminal cancer
"Going to be a sweet reunion— you and that dead whore of a wife. Get to see your lousy dead brats too. I may cry. You should be thanking me, Frankie! I'm giving you another chance to be with the family! Warm and cuddly! Come on Castiglione— Thank me!" Roc
"You're never going to be rid of me." Agent Blackwell in Suicide Run
"I'm just another liability to you. I'm sure that's the way you see it. But just make it quick, okay? Old friends and all that, right?" Microchip
"Maybe we deserve each other. Naw, I deserved better'n you. Nobody deserves a piece of filth like you. Goodbye, Frank. Goodbye, baby." Rosalie Carbone
"Together we can punish the guilty! We can clean up this city once and for all! In heaven's name, man! Isn't this exactly what you want?!" The Holy, from "Welcome Back, Frank", right before Frank mows him, Payback and Elite down
"Dosvidanja, big boy! The Russian really has to hand it to you!! HA HA HA HA HA HA!" The Russian in Army of One
"It's too much... All the sadness, all the death, it's too much for anyone to carry with them. Anyone but you." Jenny Cesare from Widowmaker, right before she blows her brains out
"Fuck off you black cunt—" Yorkie Mitchell from Long Cold Dark, before Barracuda kills him
"I'm the Kingpin." Wilson Fisk before getting his brains blown out by the Punisher
"Your City. My world." Frank Castle
"We are the last people left alive on earth. But we do have a bank of frozen embryos. And we do have the expertise to ensure their survival. We, and we alone, can save the human race. And that... well, that's all I wanted to say. Do what you will." the unnamed Corrupt Corporate Executive from The End
"I would, Ben, but then who would spot you?" H.E.R.B.I.E.
"As many times as it takes to get you off your duff and make something out of your life. At your age Johnny, your sister, Susan was already —" Franklin Storm
"You sure about this, Hank? After all the damage Ultron did, you still want to dress up like him?" The Wasp
"All of which would fold up neatly inside your Gucci suit." Beast
"Can we not just get on line? I do not want to miss getting tickets..." Nightcrawler
"Thor..." Valkyrie, who recovers. And then she dies and comes back again.
"Warren..." Dazzler, who doesn't recover.
"Where are the rest of us? Who made it out? Thor? Hawkeye? Wasp?" Captain America, who recovers.
"I'd be stating the obvious by pointing out you are NOT God. They will hunt you down. And I will lead the charge. No matter what good you think you are doing — you'll only be remembered as a madman. Like Pol Pot. Bin Laden. Hitler." Professor Xavier, who is then given a Neck Snap courtesy of Magneto.
"You know I'm not. You've had him (real Multiple Man) in hiding for weeks making duplicate after duplicate—AN ARMY OF SUICIDE BOMBERS! And it all stops now." Multiple Man "Dupe"
"Hey, pal, it was nothin' personal." The Blob, before dying the same way Wasp died.
"Charles...? Charles will understand. Charles will forgive me..." Magneto
"We are here today because history is about to be changed. Because FREEDOM is about to be changed. A vote is being take in the Senate which will make it so all mutants must surrender themselves to the United States government OR THEY WILL BE HUNTED DOWN AND SHOT ON SIGHT." Cyclops. Guess how he dies.
"This is my home. Leave now. Or I will destroy you." Doctor Doom
"No... don't touch my mask! Not my mask! NOT MY MAAASSSKK!" Sarnak
"Now, Werewolf, because it is only your blood we need, not your life... you shall die!" Baron Thunder
"All right, Russell... I want that ring!" Lt. Hackett
"You... you shot me, Cowan.... Guess I... deserved it... but I didn't mean to... kill all those people... I was just... mad... because I'm so ugly... because once... I had such a handsome—" Steven Rand / Atlas
"To what Topaz, a mockery of existence? No, child, my destiny is an ending, not noble, but merely necessary. And I need you to fulfill it. Decide quickly... before Glitternight intervenes and turns a necessity into the false nobility of wasted sacrifice." Taboo
"Yes, Jack Russell... come and destroy me... if you can." Belaric Marcosa
"No! Stop it! I won't let you do it! I'll kill you if I must!" Dr. Glitternight
"Let his death serve as an example to human and mutant alike." Rax of the Neo. Unfortunately for him, the person he's referring to here is Magneto. Yeah, ouchies.
"In moments, you will be a distant memory of time gone by." Salvo the Living Gun, same scene as above
"Yes, Nathan, what better time and place— Ah... AH..." The Watchtower Administrator
"Paint gun." Jamie Madrox, in his miniseries, when asked if he had any by Big Bad Sheila Desoto. Of course, these aren't actually his last words; he's referring to the paint gun he used to fake Sheila's husband's death, allowing said husband the opportunity to shoot Sheila with a real one.
"My girls... How'd Bastion know about my girls..." The Vanisher, after discovering his favorite brothel raided by and being machine-gunned by Steven Lang. Technically, the scene cuts away before he actually expires, but he hasn't been seen since then
"... So this is how it ends... surrounded by smoke and genetic filth. I can admit without shame that I am disappointed I won't be here to witness your extinction... but do not think I regret what I have sacrificed here today. Bastion comes for you — and when he does, when you see the light of his future fire raining down on your benighted "race" — KNOW THAT HIS CLEANSING LIGHT BURNS WITH BUT A FRACTION OF MY PROFOUND HATRED FOR--" Donald Pierce. Cyclops shuts him up by blasting him in half
"Get your finger out of my-" Sack
"He'll be back in charge any second. I'm sorry. No time — God bless you." Bolivar Trask, before shooting himself to keep Bastion from controlling his mind
"Never mind me. Check on Cypher." Cable. Not very climactic; his actual last action is a smile to his adoptive daughter Hope
"Don't you get it, Bastion? It's over! You failed! We have to get out of here and regroup... Lang... for the love of God, talk to it..." Graydon Creed
"Creed's right. Whatever they did, the Sentinels are down, our forces are scattered, and there are too many of them for—" Steven Lang. Bastion refuses to give up and transforms the both of them into mindless Killer Robots
"It is beyond out capacity to hate you. It is beyond our capacity to enjoy murdering you. We have grown beyond our capacity. Because we do hate you, and we will enjoy killing—" Bastion
"I stole this one too... From Kraven." Mysterio, before committing suicide.
"A billion to one... you think I'm afraid of that? YOU THINK I'M AFRAID OF THAT?! FLAME ON!" Johnny Storm, The Human Torch
"For what it's worth, I'm sorry." J. Jonah Jameson to Spider-Man in DC vs. Marvel, when it looked like The End of the World as We Know It. This was in response to Spidey asking if JJJ wanted to insult him one last time before it all ended; after Jonah says the above line, Peter can only manage a quiet "...Oh."
"Sorry, but the world needs Captain America more than Bucky!" Bucky Barnes, though this demise becomes retconned.
"It was a mistake to come here, M'baku! The White Gorilla tribe was exiled long ago! Your mere existence is forbidden! But still, I have respected you and your lands, and this is how you repay me?" T'Chaka
"Wait! Waaaaaaaaaaiiiiiiiiiiit!" Wonder Man
"A gift from Klaw. Fitting, you meet the end the same way your father did. You are not even the man he was. You go to outsiders for help? No outsider can help you now." Man-Ape
"Have at thee, machine!" Thor. He comes back.
"What do you hope to accomplish here? No virus can stop me." Ultron-6
"You dare come here and challenge me! Tell your master he has made a great mistake! Nobody challenges Karnilla! I am—" Karnilla
"No! No! No!" Arnim Zola
"Enough, Zemo! I'm not going to stand by and watch anymore! I'm not gonna let you hurt anyone else because I'm afraid!" Wonder Man (again)
"No! No one's that good." Skrull!Hawkeye
"We are everywhere, you'll see." Skrull!Iron Man
"You are nothing to me. One by one, I will destroy you. I will never tire. I will never show mercy. I will never stop until each and every one of you are deó!" Ultron-7
"You know what? This was a bad idea. Why don't you leave? Now?" Hank Pym, before getting "killed" by Yellowjacket
"I only do now as my father did. I protect Wakanda. But unlike any other Black Panther, I have had the privilege of doing it by your sides as an Avenger." Black Panther. He comes back.