Vincent Chase (Adrian Grenier)
"I got into this business so I wouldn't have to work."
A pretty boy with who we're told is a decent actor
. Vince has co-dependency issues and is a notorious womanizer. Never goes anywhere without one of his "boys".
Eric "E" Murphy (Kevin Connolly)
"Johhny Depp did "Pirates of the Caribbean". And if I'm not mistaken, he wore a swashbuckling costume and carried a sword."
Vince's best friend since childhood, who takes on the role of his manager (unofficially, then officially). Eric is just about as co-dependent as Vince, but slightly more self-aware. Less of a womanizer, he's more of a serial monogamist.
- The Chick: E has shades of this. He has a tendency to get too attached in relationships.
- Heterosexual Life-Partners: With Vince.
- In Love with Love: Vince even comments once that E likes to fall in love at the drop of a hat.
- The Lancer / The Smart Guy
- Only Sane Man
- Office Romance: E begins managing Anna Faris (playing herself, of course) after getting into a fender-bender with her. He quickly becomes infatuated with her and indirectly causes her to break up with her boyfriend. She fires him as her manager because of his feelings for her as well as his personal dislike for a script she was offered.
Johnny "Drama" Chase (Kevin Dillon)
"I've been working steady for the past 12 years, minus the last 3."
Vince's older (half)brother, who's been in the acting biz longer, but with not nearly as much success. Goes by "Drama" because well, he's a bit of a basket case
- Actor Allusion
- Big Brother Instinct: Drama is very protective of his "baby bro" Vince, and is always willing to help whenever Vince is in trouble.
- The Big Guy
- Casanova Wannabe: Drama considers himself to be a real ladies' man, but more often than not we see him getting rejected.
- The Chick: Drama has shades of this and is overly dramatic.
- Expansion Pack Past: Drama has a story about anyone/everyone in Hollywood, but somehow none of the other guys have heard them before.
- Large Ham
- Old Shame: An in-universe subversion; it turns out Drama loves the cult status of what should be an Old Shame - Viking Quest.
- Small Name, Big Ego
- Tall, Dark and Snarky
- Team Chef: Drama is such a good cook that Vince has actually hired him as his personal chef. In one episode, he buys a condo specifically because he loves the kitchen so much.
Salvatore "Turtle" Assante (Jerry Ferrara)
"This is where you should be living, Vince. In a kingdom, like a prince."
Another of Vince's friends from childhood, but often hangs out with Drama. Came to Hollywood to act as Vince's driver, he enjoys being a hanger on with the least amount of guilt out of the three. At least for a while
Ari Gold (Jeremy Piven)
"Call me Helen Keller because I'm a fucking miracle worker!"
Vince's agent, a foul-mouthed, ruthless businessman, responsible for much of Vince's success. Although his demeanor can be off-putting, he's one of the most popular characters on the show, and has proven time and time again that he truly cares for Vince beyond just his career.
- The Ace
- Bad Boss: Enjoys ripping his underlings with gusto...
- Berserk Button: Ari's loud and belligerent normally, but the things that will truly make him angry are double-crossing him, questioning his word or disrespecting his family.
- Expy: Of real-life Hollywood agent Ari Emmanuel.
- Happily Married: Ari is quite devoted to his wife and insists that he has never cheated on despite having many opportunities. When she leaves him in the show's final season, he is absolutely crushed and falls into a depression.
- Jerk with a Heart of Gold: Ari Gold actually cares a lot about those around him, and will save many an employee from getting fired by Babs. On top of that, he's clearly devoted to his wife & children. He also genuinely cares about Vince, and is devastated when Vince fires him at one point.
- Indy Ploy: Very good at thinking on his feet.
- Married to the Job: Hollywood is a harsh and demanding mistress.
- No Indoor Voice
- Old Flame: Dana Gordon, whom he had a relationship with before he met his wife. In the final season, Ari and Dana tempoarily rekindle their romance after Ari's wife leaves him. But Ari breaks up with Dana after realizing that he's still in love with his wife.
- Pet the Dog: He's a friend of his friends and a devoted family man.
- Smug Snake: He is as arrogant as competent.
Lloyd Lee (Ryan Lee)
Ari Gold's much put-upon assistant.
'''Melissa "Mrs. Ari" Gold (Perrey Reeves)
Ari's long-suffering wife and the mother of his children. She is one of the few people unintimidated by Ari's personality and is shown to be quite capable of standing up to him. She is also a trust fund baby and former soap opera actress.
- Happily Married: Although they sometimes argue, Mrs. Ari is shown to be supportive of her husband and willing to stand by him through thick and thin. Until the final season, when she decides that she's had enough of her husband putting his job before his family and leaves him. Thankfully, the two of them reconcile.
- Housewife: Has no job (although she used to be an actress) and spends her time raising her children and working for various charities.
- No Name Given: For most of the show's run, she was referred to only as "Mrs. Ari" or "Ari's wife." In the final season we learn that her first name is Melissa.
- Old Shame: An in-universe example. In Season 5 it's revealed that she once starred in an erotic movie.
Sloan McQuiewick (Emmanuelle Chriqui)
E's on again, off again girlfriend. In the final season she becomes pregnant with E's baby, and the two of them fly off to an unknown location.
- Ambiguously Brown
- Average guy, hot girlfriend: Shortly after Sloan and E begin dating, Ari comments to E that "Sloan is way too hot for you."
- Has a Type: In her first appearance she mentions that she doesn't date actors.
- Prenup Blowup: When E and Sloan become engaged, Sloan's father insists that E sign a prenupual agreement that will prevent him from getting any of Sloan's family fortune if the two of them get a divorce. E is insulted by the idea of signing a prenup and the fact that Sloan sides with her father eventually leads to them breaking off the engagement.
- Spoiled Sweet: She has filthy rich parents, but remains very down-to-earth and humble.
- Will They or Won't They?: E and Sloan break up and get back together multiple times during the course of the show. When they finally get back together at the end of the final season not many people were surprised.
Billy Walsh (Rhys Coiro)
An acclaimed independant film director whose work includes two movies starring Vincent Chase (Queens Boulevard
- Bad Boss: During the filming of Medellin Walsh becomes increasingly unhinged and terrorizes the cast and crew of the film.
- Creator Killer: An in-universe example. Medellin ends up being such a terrible movie that it kills Walsh's career as a film director. In season 7 he comes to Vince and the gang looking for work, and becomes the director of an animated television series called Johnny's Bananas.
- Heel-Faith Turn: Walsh returns in Season 7 after a two year absence, and we learn that he has spent those years turning his life around and trying to become a better person. In fact, he has even become an ordained minister.
- Jerk with a Heart of Gold: When Medellin is booed at its premiere, Walsh stands up and angrily chastises the crowd for being disrepectful to the cast and crew who worked on it.
- No Celebrities Were Harmed: According to the season 2 commentary, Billy Walsh was based on Entourage writer Rob Weiss as well as actor/director Vincent Gallo.