!'''Vincent Chase (Adrian Grenier)'''
--> ''"I got into this business so I wouldn't have to work."''

A pretty boy with who [[InformedAbility we're told is a decent actor]]. Vince has co-dependency issues and is a notorious womanizer. Never goes anywhere without one of his "boys".

* AmbiguouslyBrown: In real life Adrian Grenier is half Mexican and part Indian but Vince's full ethnic origins are never explained. In one episode, he claims his grandfather is Japanese while in another episode he says he is part Italian. He has also claimed to be Irish. When preparing to play Pablo Escobar in a biopic he says that he fits the role because he is part Hispanic.
* AuthorAvatar / MarySue {{Expy}}: Of Creator/MarkWahlberg
* BeardOfSorrow: Vince grows one after ''Medellin'' flops.
* BrainlessBeauty: Let's face it, the guy's a total [[Series/{{Seinfeld}} mimbo]].
* BrilliantButLazy: Several characters have said that Vince is a talented actor, but began phoning in his performances and relying too much on his good looks and name after he achieved his early success.
* TheCasanova: Vince is rarely unsuccessful in his attempts to seduce women.
* DoingItForTheArt: In-universe. Vince frequently states that he doesn't ''need'' the fame or fortune, and would rather do a low budget film that he's passionate about (Such as ''Queen's Boulevard'' or ''Medillin'') over a forgettable film that would provide a fat paycheck; and had no interest in ''Aquaman'' until James Cameron signed on as director.
* [[spoiler:DrugsAreBad: In Season 7 Vince develops a drug problem while dating [[AsHimself real-life porn star Sasha Grey]]. Vince's friends end up staging an intervention and convincing him to go to rehab.]]
* TheHero
* HeterosexualLifePartners: With E.
* InformedAbility: We are told Vince is a good actor, though we rarely see him acting. The few occasions we do, it's hard to tell because we have no frame of reference for his performance.
* ItsAllAboutMe: Many times he will make a decision without any regard to how it affects other people.
* MrFanservice
* UngratefulBastard: Has a few instances of this towards E, such as getting upset that E got sick of Vince treating him like his manager despite Vince's own refusal to hire E in the role.
** WhatTheHellHero: The situation is usually resolved when Vince expects Drama & Turtle to back him up, only for them to side with E.

!'''Eric "E" Murphy (Kevin Connolly)'''
--> ''"Creator/JohhnyDepp did "Franchise/PiratesOfTheCaribbean". And if I'm not mistaken, he wore a swashbuckling costume and carried a sword."''

Vince's best friend since childhood, who takes on the role of his manager (unofficially, then officially). Eric is just about as co-dependent as Vince, but slightly more self-aware. Less of a womanizer, he's more of a serial monogamist.

* TheChick: E has shades of this. He has a tendency to get too attached in relationships.
* {{Expy}}: Of Mark's manager Eric Weinstein.
* HeterosexualLifePartners: With Vince.
* InLoveWithLove: Vince even comments once that E likes to fall in love at the drop of a hat.
* InNameOnly: An in-universe ''inversion'' - throughout the first season, E is constantly treated as Vince's manager by everyone, even though Vince refuses to actually hire him as such, which essentially made "I'm[=/=]He's not his[=/=]my manager." into Vince & E's catchphrase.
* TheLancer / TheSmartGuy
* NaiveNewcomer: Most of the time Ari gets mad at E because the latter doesn't understand how the business side of Hollywood works.
* OnlySaneMan
* OfficeRomance: E begins managing Creator/AnnaFaris (playing herself, of course) after getting into a fender-bender with her. He quickly becomes infatuated with her and indirectly causes her to break up with her boyfriend. She fires him as her manager because of his feelings for her as well as his personal dislike for a script she was offered.
* RelationshipRevolvingDoor: With Sloan, over and over again.

!'''Johnny "Drama" Chase (Kevin Dillon)'''
--> ''"I've been working steady for the past 12 years, minus the last 3."''

Vince's older (half)brother, who's been in the acting biz longer, but with not nearly as much success. Goes by "Drama" because well, he's a [[ExactlyWhatItSaysOnTheTin bit of a basket case]].

* ActorAllusion
* BigBrotherInstinct: Drama is very protective of his "baby bro" Vince, and is always willing to help whenever Vince is in trouble.
* TheBigGuy
* CasanovaWannabe: Drama considers himself to be a real ladies' man, but more often than not we see him getting rejected.
* TheChick: Drama has shades of this and is overly dramatic.
* ExpansionPackPast: Drama has a story about anyone/everyone in Hollywood, but somehow none of the other guys have heard them before.
* {{Expy}}: Of Mark's cousin Johnny "Drama" Alves.
* LargeHam
* OldShame: An in-universe subversion; it turns out Drama loves the cult status of what ''should'' be an Old Shame - ''Viking Quest''.
* SmallNameBigEgo
* TallDarkAndSnarky
* TeamChef: Drama is such a good cook that Vince has actually hired him as his personal chef. In one episode, he buys a condo specifically because he loves the kitchen so much.

!'''Salvatore "Turtle" Assante (Jerry Ferrara)'''
--> ''"This is where you should be living, Vince. In a kingdom, like a prince."''

Another of Vince's friends from childhood, but often hangs out with Drama. Came to Hollywood to act as Vince's driver, he enjoys being a hanger on with the least amount of guilt out of the three. [[CharacterDevelopment At least for a while]].

* DrunkenMaster: A variation on the trope; Turtle is only good at video games when he's high on marijuana.
* {{Expy}}: Of Mark's late assistant Donnie "Donkey" Carroll.
* TheLoad: At least until CharacterDevelopment kicks in.
* OnlyKnownByTheirNickname
* PrettyFlyForAWhiteGuy: In one episode, Turtle even chastises drama by saying "Do you have to act so white?"
* RagsToRiches: Goes from mooching off Vince to becoming a multi-millionaire by the time of the film.
* TheStoner
* [[TagalongKid Tagalong Guy]]

!'''Ari Gold (Jeremy Piven)'''
[[caption-width-right:350:''Adam Daaaaaaavies?!!!'']]

--> ''"Call me Helen Keller because I'm a fucking miracle worker!"''

Vince's agent, a foul-mouthed, ruthless businessman, responsible for much of Vince's success. Although his demeanor can be off-putting, he's one of the most popular characters on the show, and has proven time and time again that he truly cares for Vince beyond just his career.

* TheAce: Ari may not be nice, but he's so good at his job that he's become the most powerful and influential agent in Hollywood.
* BadBoss: Enjoys ripping his underlings with gusto...
* BerserkButton: Ari's loud and belligerent normally, but the things that will truly make him angry are double-crossing him, questioning his word or disrespecting his family.
* {{Expy}}: Of real-life Hollywood agent Ari Emmanuel.
* HappilyMarried: Ari is quite devoted to his wife and insists that he has never cheated on despite having many opportunities. [[spoiler: When she leaves him in the show's final season, he is absolutely ''crushed'' and falls into a depression.]]
* HotBlooded: To put it mildly.
* {{Jerkass}}
** JerkWithAHeartOfGold: Ari Gold actually cares a lot about those around him, and will save many an employee from getting fired by Babs. On top of that, he's clearly devoted to his wife & children. He also genuinely cares about Vince, and is devastated when Vince fires him at one point.
* IndyPloy: Very good at thinking on his feet.
* MarriedToTheJob: Hollywood is a harsh and demanding mistress.
* NoIndoorVoice
* OldFlame: Dana Gordon, whom he had a relationship with before he met his wife. [[spoiler:In the final season, Ari and Dana tempoarily rekindle their romance after Ari's wife leaves him. But Ari breaks up with Dana after realizing that he's still in love with his wife.]]
* PetTheDog: He's a friend of his friends and a devoted family man.
* SmugSnake: He is as arrogant as competent.

!'''Lloyd Lee (Rex Lee)'''

Ari Gold's much put-upon assistant.

* BeleagueredAssistant
* ButtMonkey: Ari's personal ChewToy
* CampGay
* TheDanza
* MyMasterRightOrWrong: Loyally devoted to Ari, with punctual exceptions.
* TookALevelInBadass: Becomes a competent agent on his own.
* YourCheatingHeart: Cheats on his boyfriend. This gets quickly exploited by Ari.

!'''[[spoiler:Melissa]] "Mrs. Ari" Gold (Perrey Reeves)

Ari's long-suffering wife and the mother of his children. She is one of the few people unintimidated by Ari's personality and is shown to be quite capable of standing up to him. She is also a trust fund baby and former soap opera actress.

* HappilyMarried: Although they sometimes argue, Mrs. Ari is shown to be supportive of her husband and willing to stand by him through thick and thin. [[spoiler:Until the final season, when she decides that she's had enough of her husband putting his job before his family and leaves him. Thankfully, the two of them reconcile.]]
* {{Housewife}}: Has no job (although she used to be an actress) and spends her time raising her children and working for various charities.
* NoNameGiven: For most of the show's run, she was referred to only as "Mrs. Ari" or "Ari's wife." [[spoiler:In the final season we learn that her first name is Melissa.]]
* OldShame: An in-universe example. In Season 5 it's revealed that she once starred in an erotic movie.
* {{Socialite}}

!'''Sloan [=McQuiewick=] (Emmanuelle Chriqui)'''

E's on again, off again girlfriend. [[spoiler:In the final season she becomes pregnant with E's baby, and the two of them fly off to an unknown location.]]

* AmbiguouslyBrown
* UglyGuyHotWife: Average guy, hot girlfriend: Shortly after Sloan and E begin dating, Ari comments to E that "Sloan is way too hot for you."
* HasAType: In her first appearance she mentions that she doesn't date actors.
* PrenupBlowup: When E and Sloan become engaged, Sloan's father insists that E sign a prenupual agreement that will prevent him from getting any of Sloan's family fortune if the two of them get a divorce. E is insulted by the idea of signing a prenup and the fact that Sloan sides with her father eventually leads to them breaking off the engagement.
* {{Socialite}}
* WillTheyOrWontThey: E and Sloan break up and get back together multiple times during the course of the show. [[spoiler:When they finally get back together at the end of the final season not many people were surprised.]]

!'''Billy Walsh (Rhys Coiro)'''

An acclaimed independant film director whose work includes two movies starring Vincent Chase (''Queens Boulevard'' and ''Medellin'')

* BadBoss: During the filming of ''Medellin'' Walsh becomes increasingly unhinged and terrorizes the cast and crew of the film.
* CreatorKiller: An in-universe example. ''Medellin'' ends up being such a terrible movie that it kills Walsh's career as a film director. In season 7 he comes to Vince and the gang looking for work, and becomes the director of an animated television series called ''Johnny's Bananas''.
* HeelFaithTurn: Walsh returns in Season 7 after a two year absence, and we learn that he has spent those years turning his life around and trying to become a better person. In fact, he has even become an ordained minister.
* JerkWithAHeartOfGold: When ''Medellin'' is booed at its premiere, Walsh stands up and angrily chastises the crowd for being disrepectful to the cast and crew who worked on it.
* NoCelebritiesWereHarmed: According to the season 2 commentary, Billy Walsh was based on ''Entourage'' writer Rob Weiss as well as actor/director Vincent Gallo.