Roseanne and Dan have just found out that Rosanne's sister, Jackie, was being physically abused by her boyfriend. As Rosanne takes Jackie to the hospital, Dan just stands there, looking very pissed... before grabbing his coat and stomping out the door, clearly out for blood. Half the studio audience did the standard dramatic "Ohhh!" The other half applauded.
Roseanne: Well, what did he say?
Dan: Mostly "Ow, ow, my head."
A better moment is later on when the police come to arrest Dan after Fisher calls the police afterwards. Dan insists on going along quietly.
Also, from the second half of the two parter of the above episode, Roseanne's final words to Jackie's boyfriend, Fisher:
Roseanne: You just make sure you never come near Jackie again, because to get to her, you'll have to get through me, and I'm a lot more dangerous than Dan. I own a loose meat restaurant; I know what to do with the body.
The episode "Roseambo". Roseanne kicking some serious terrorist ass was awesome enough, but when one of the remaining guys snuck through the window and tried to attack, Mark immediately whirls around and shoves the guy through an open window.
Roseanne: Mark, remember all those times you screwed up? This isn't one of them.
When Becky leaves and decides to start staying with Jackie, it causes a lot of friction between Jackie, Dan, and Roseanne. When Darlene visits her at Jackie's apartment she calls her sister out on the fact that her selfishness is causing everyone to be miserable, and points out that she was the one who covered for her, and got grounded, when she lied about Becky going out with Mark and Becky never came to her defense.
Darlene: Becky, you're a selfish, inconsiderate, spoiled little brat!
And of course, in all fairness, Becky rightfully called Darlene out when she did a personality overhaul and spent her time loafing around the house being miserable.
In Home Economics D.J. was being bullied at school by Kevin Morgan, who told him to bring him a Twinkie every day. However, Kevin's dad comes to the Conner house and insists that D.J. has been bullying Kevin. D.J. explains that he decided to get an older girl named Maxine Spencer to bully Kevin, by giving her a Twinkie every day. D.J. then explains that he tells Kevin he'll get Maxine to back off in exchange for two Twinkies every day. D.J. keeps one for himself and gives the other to Maxine as payment.