Roseanne and Dan have just found out that Roseanne's sister, Jackie, was being physically abused by her boyfriend. As Roseanne takes Jackie to the hospital, Dan just stands there, looking very pissed... before grabbing his coat and stomping out the door, clearly out for blood. Half the studio audience did the standard dramatic "Ohhh!" The other half applauded.
Roseanne: Well, what did he say?
Dan: Mostly "Ow, ow, my head."
A better moment is later on when the police come to arrest Dan after Fisher calls the police afterwards. Dan insists on going along quietly.
Also, from the second half of the two parter of the above episode, Roseanne's final words to Jackie's boyfriend, Fisher:
Roseanne: If you ever come near her again you're gonna have to deal with me, and I am way more dangerous than Dan. I got a loose meat restaurant; I know what to do with the body.
And then she breaks his television.
The episode "Roseambo". Roseanne kicking some serious terrorist ass was awesome enough, but when one of the remaining guys snuck through the window and tried to attack, Mark immediately whirls around and shoves the guy through an open window.
Roseanne: Mark, remember all those times you screwed up? This isn't one of them.
In the episode "Don't Make Me Over", Becky and Darlene give Roseanne a beauty spa package for Mother's Day, trying to butter her up and let them go to an out of town concert for a weekend. Roseanne, thinking that they were actually trying to be nice to her for a change, is heartbroken when she learns the truth and is reduced to tears. Dan steps in and saves the day by giving the girls a very deserving tongue-lashing, carting them off to be with Bev for a very boring weekend, and taking Roseanne out for a romantic dinner and weekend. This was after Roseanne had complained earlier that Dan was not a good disciplinarian.
When Becky leaves and decides to start staying with Jackie, it causes a lot of friction between Jackie, Dan, and Roseanne. When Darlene visits her at Jackie's apartment she calls her sister out on the fact that her selfishness is causing everyone to be miserable, and points out that she was the one who covered for her, and got grounded, when she lied about Becky going out with Mark and Becky never came to her defense.
Darlene: Becky, you're a selfish, inconsiderate, spoiled little brat!
Of course, Becky returned the favor in "Stressed to Kill". Becky had had anger bubbling for weeks during Darlene's depression, since she was picking up all the slack in terms of chores and getting nothing while Darlene laid around on the couch and was being fawned over. When Becky helped Darlene with a history paper and only got yelled at for her trouble, she finally let Darlene have it.
Becky: You know, I don't believe you Darlene. I help you out with your paper and you get me nailed for it.
Darlene: Look, I apologized for that yesterday. Besides, I didn't ask for your help. You just felt sorry for me and I don't need your damn pity.
Becky: Are you kidding? You're begging for it. "Oh, high school is too hard. My friends don't like me. Nobody understands me." Well, then do something about it, you little wimp!
Darlene: Shut up Becky. You don't know what you're talking about.
Becky: Of course not, 'cause you're so complex, you're so deep. Well, that's crap. You're just a whiny little basket case who's milking this depression thing for all it's worth. So here it is, four in the afternoon and you get to do exactly what you want, well, way to go. Now excuse me, but I got a zillion chores to do or Mom and Dad are gonna kick my butt.
In "Home Economics", D.J. was being bullied at school by Kevin Morgan, who told him to bring him a Twinkie every day. However, Kevin's dad comes to the Conner house and insists that D.J. has been bullying Kevin. D.J. explains that he decided to get an older girl named Maxine Spencer to bully Kevin, by giving her a Twinkie every day. D.J. then explains that he tells Kevin he'll get Maxine to back off in exchange for two Twinkies every day. D.J. keeps one for himself and gives the other to Maxine as payment.
Dan: Woah, back up there or I'll give my wife a doughnut to beat YOUR butt!"
David gets two in one of the Thanksgiving episodes. When he discovers that Mark knows absolutely nothing about football, David offers to teach him about it. When Mark starts making fun of him regardless, David makes up a bunch of nonsense just so Mark will embarrass himself. During the end credits, when Mark is still being an Ungrateful Bastard as David fixes a rip in his jeans, David pulls out the seams from the back and Mark walks out of the room unaware that his bare ass is showing.
David gets yet another in "Lost Youth". After Mark spends the entire episode bullying him and flirting with a girl he likes out of pure spite, David finally calls him out: "You were willing to risk your own marriage just to hurt me! [...] Put me down, take a girl away from me, whatever it takes to make you feel superior. Just remember, Mark, besides Becky I'm the only person around here who gives a crap about you!" Mark immediately goes off to break the plans he'd made with the girl.
In "Chicken Hearts", Roseanne is employed at a fast food restaurant. Her boss Brian is an obnoxious teenager who forces her to work weekends, even though she made him promise not to do so when she first took the job, as she needs to be home for her kids. When she discovers that Brian is struggling with an auto shop assignment, she decides to invite him over for dinner and have Dan do the project for him in an attempt to get on his good side. He accepts, but still fires her at the end of the evening, which immediately begins a series of Moments of Awesome. Dan nearly tears Brian's head off in anger; Becky and Darlene call the kid out for being a jerk (this is especially awesome as both can occasionally be nasty to their mother); Roseanne delivers a speech that points out that Brian, for all his cockiness, is nothing but a spoiled brat; Dan, Becky and Darlene destroy his project and hand him the pieces as he walks through the living room; and Roseanne caps his visit off by asking "Would you like fries with that?" and slamming the door in his face.
The "Wellman Walkout". In "Let's Call It Quits", their obnoxious, condescending, and sexist boss Mr. Faber has set unrealistic quotas for the factory workers. Roseanne discusses it with him, and he says he'll lower the quotas if she'll show him some (undeserved) respect. She does, and he turns around and raises the quotas back to their original numbers. When she goes to confront him and ask why he did it, he says simply "Because I can," and when he realizes he could break her, he could get the others to do whatever he wanted. Roseanne tears him a new one about it and storms off. He goes after her and Roseanne simply can't take it anymore, and she (followed by the other girls) very calmly all walk over, promptly take their time cards, punch out, and walk away. As they leave, Roseanne turns and says, "I guess we won't be making our quotas today, honeybunch."