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Tear Jerker: Roseanne
Roseanne has a few emotional scenes, but the one that truly qualifies at tearjerker is the final episode. In the end Roseanne confesses that all of the events since Dan's heart attack were made up. In fact, Dan died that day. The final shot shows an apathetic looking Roseanne sitting in front of the TV, eating chips, indicating that she might have lost her lust for life. Thus the series ends on a bitter note. If you take that scene along with the voice-over right before, it sounds like she only briefly gave into food and depression, but got out of her funk and chose to be alive when Darlene's baby was premature, making that last scene on the couch more of a Bittersweet Ending.
The episode around the birth of Darlene's baby, but especially the scene when all the Conner/Harris women gather to take her off life support, and Darlene breaks down. Both Sara Gilbert and Johnny Galecki pull out all their acting chops.
One of the things which must be considered about this episode was that, in the context of the entire last season, this event actually happened and not something Roseanne had made up. Darlene did have her baby prematurely and it nearly died, but in real life the family didn't have Dan nor did they have all that money which Roseanne spent on numerous doctors and specialists to give her granddaughter the absolute best care. Imagine what it must've been like to go through that without as many options as Roseanne had written about.
The scene in the fifth season, after Dan gets home from jail and Jackie calls him out for beating up Fisher. It's both hilarious and tear-jerking, especially Jackie says Roseanne's always helping her with her problems, then Dan responds "It's a big job, we had to expand the department."
The knock-down drag-out fight Dan and Roseanne have after his heart attack, in which he won't change the unhealthy habits that caused it in the first place. It's pretty wrenching to watch in the first place, as this is a couple who for all their ups and downs, have been Happily Married for years. Seeing them fight to the point where one of them outright walks out on the other is stunning. Then when you learn a year later that Dan actually died after his heart attack and you realize that the fight symbolized Roseanne's internal anguish and anger at herself and him, it gets even worse.